Antinociceptive effect of flavonol and a few structurally related dimethoxy flavonols in mice

Sayeli, Vijaykumar; Nadipelly, Jagan; Kadhirvelu, Parimala; Cheriyan, Binoy Varghese; Shanmugasundaram, Jaikumar; Subramanian, Venkataraman

doi:10.1007/s10787-019-00579-4

Cited by 7 publications

(7 citation statements)

References 45 publications

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Section: ‐Hydroxy Flavonementioning

confidence: 99%

“…Treatment with flavonol and dimethoxyflavonols resulted in a significant reduction in the number of abdominal constrictions in the acetic acid test, a significant inhibition of the paw-licking/biting response time in both the phases of formalin nociception and also a significant increase in the mean reaction time in the hot water tail immersion test (exhibited in Table 1). [30] Reported the 3-hydroxyflavone inhibits human osteosarcoma U2OS and 143B cells metastasis. 3-Hydroxyflavone suppresses human osteosarcoma up to 50 μM without cytotoxicity, inhibited U2OS and 143B cells motility, invasiveness and migration by reducing matrix metalloproteinase (MMP)-2 and urokinasetype plasminogen activator (u-PA), and also impaired cell adhesion to gelatin.…”

Section: Mutagenicitymentioning

confidence: 99%

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An Overview of Pharmacological Activities and Beneficial Effects of 3‐Hydroxyflavone

Ayyanna,

Kuppusamy,

Kumar

2024

Macromolecular Symposia

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Flavonoids are a diverse group of naturally occurring plant compounds that are primarily composed of phenols in their free form or glycosides. Flavonoid medicines are primarily composed of 2‐phenyl‐g‐benzopyrone. This family consists of monomeric flavanols, flavanones, anthocyanidins, flavones, isoflavonoids, and flavonols. The study's main objective is to review the newly discovered natural flavones and flavanols, as well as the biological and pharmacological actions of these essential flavonoids. As per the available data, 3‐hydroxy flavone plays a vital role in the prevention of a range of diseases. Research studies have confirmed that 3‐hydroxyflavone has a broad range of pharmacological properties like therapeutic effects against pain, inflammation, oxidative stress; hepatotoxicity, hypertension, ulcerogenesis, allergy, platelet dysfunction, microbes, fungi, viruses, rhinovirus, malaria, and carcinogens. 3‐Hydroxy flavone has limited utility because of their poor solubility and bioavailability. This has led to the search for new drug delivery methods, such as nanoparticles. To get over these problems, it would be preferable to administer 3‐hydroxyflavone via the biocompatible nanoparticles. It is expected that nanoparticles will improve the solubility of 3‐hydroxyflavone, enhance its therapeutic properties and facilitate its transport to the brain.

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Section: ‐Hydroxy Flavonementioning

confidence: 99%

Section: Mutagenicitymentioning

confidence: 99%

An Overview of Pharmacological Activities and Beneficial Effects of 3‐Hydroxyflavone

Ayyanna,

Kuppusamy,

Kumar

2024

Macromolecular Symposia

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“…[6][7][8] Flavonols are secondary metabolites that fall into the category of flavonoids and have a broad distribution across various plant groups, including brassica, angiosperms, gymnosperms, mosses, liverworts, and ferns, [9][10][11] and exhibit a broad spectrum of biological activities, including antiviral, [12] antifungal, [13] anticancer, [14] antioxidant and anti-inflammatory properties. [15][16] Although the medical field has extensively researched this topic, [17][18] the study has been limited in the field of pesticides. The quinazoline backbone, comprising two fused six-membered aromatic rings (a benzene ring and a pyrimidine ring), is significant in developing and innovating new drugs due to its diverse pharmacological properties.…”

Section: Introductionmentioning

confidence: 99%

Flavonol Derivatives Containing a Quinazolinone Moiety: Design, Synthesis, and Antiviral Activity

Gong,

Meng,

Sun

et al. 2024

Chemistry & Biodiversity

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A series of flavonol derivatives containing quinazolinone were designed and synthesized, and their antiviral activities against tobacco mosaic virus (TMV) were evaluated. The results of the half maximal effective concentration (EC50) test against TMV showed that the EC50 value of curative activity of K5 was 139.6 μg/mL, which was better than that of the commercial drug ningnanmycin (NNM) 293.1 μg/mL, and the EC50 value of protective activity of K5 was 120.6 μg/mL, which was superior to that of NNM 207.0 μg/mL. The interaction of K5 with TMV coat protein (TMV‐CP) was investigated using microscale thermophoresis (MST) and molecular docking and the results showed that K5 can combine with TMV‐CP more strongly to TMV‐CP than that NNM can. Furthermore, the assay measuring malondialdehyde (MDA) content indicated that K5 had the ability to improve the disease resistance of tobacco. Hence, this study offers strong evidence that flavonol derivatives have potential as novel antiviral agents.

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“…Flavonols, 3-hydroxyl flavones, are a unique flavonoid mainly found in dicotyledonous plants, especially in the flowers and leaves of some woody plants, such as the ginkgo biloba, sea buckthorn, and sophora flowers. , Flavonoids, as important products of plant secondary metabolism, have various excellent physiological activities, extensive sources, minimal side effects, and exceptional safety . Moreover, flavonols and their derivatives have good antiviral, , antibacterial, , insecticidal, , antioxidant, anticancer, , and other biological activities, and are widely used in the fields of pesticides and pharmaceuticals.…”

Section: Introductionmentioning

confidence: 99%

Novel Flavonol Derivatives Containing 1,3,4-Thiadiazole as Potential Antifungal Agents: Design, Synthesis, and Biological Evaluation

Zhou,

Gong,

Sun

et al. 2024

ACS Omega

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In order to discover novel compounds with excellent agricultural activities, novel flavonol derivatives containing 1,3,4-thiadiazole were synthesized and evaluated for their antifungal activities. The bioassay results showed that some of the target compounds had good antifungal activities against Botrytis cinerea, Phomopsis sp. and Sclerotinia sclerotiorum in vitro. It is worth noting that the half-effective concentration (EC 50 ) value of Y18 against B. cinerea was 2.4 μg/mL, which was obviously superior to that of azoxystrobin (21.7 μg/mL). The curative activity of Y18 at 200 μg/mL (79.9%) was better than that of azoxystrobin (59.1%), and its protective activity (90.9%) was better than that of azoxystrobin (83.9%). Morphological studies by using scanning electron microscopy and fluorescence microscopy revealed that Y18 could affect the normal growth of B. cinerea mycelium. In addition, the mechanism of action studies indicated that Y18 could affect the integrity of cell membranes by inducing the production of endogenous reactive oxygen species and the release of the malondialdehyde content, leading to membrane lipid peroxidation and the release of cell contents. The inhibitory activity of flavonol derivatives containing 1,3,4-thiadiazole on plant fungi is notable, offering significant potential for the development of new antifungal agents.

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Antinociceptive effect of flavonol and a few structurally related dimethoxy flavonols in mice

Cited by 7 publications

References 45 publications

An Overview of Pharmacological Activities and Beneficial Effects of 3‐Hydroxyflavone

An Overview of Pharmacological Activities and Beneficial Effects of 3‐Hydroxyflavone

Flavonol Derivatives Containing a Quinazolinone Moiety: Design, Synthesis, and Antiviral Activity

Novel Flavonol Derivatives Containing 1,3,4-Thiadiazole as Potential Antifungal Agents: Design, Synthesis, and Biological Evaluation

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