Antinociceptive effect of Encholirium spectabile: A Bromeliaceae from the Brazilian caatinga biome

Abstract

Background:Encholirium spectabile is a species found in outcrops rocky throughout the Brazilian Caatinga.Objective:This study was carried out to evaluate the antinociceptive effects of ethanolic extract of the leaves from E. spectabile (Es-EtOH) in mice using chemical and thermal models of nociception.Material and Methods:HPLC was used to determine the fingerprint chromatogram. The Es-EtOH was examined for its antinociceptive activity at the doses of 100, 200 and 400 mg/kg intraperitoneal (i.p.). The evaluation of antinociceptive activity was carried out by the acetic acid-induced writhing, formalin and hot plate tests in mice. Rota-rod test was used for the evaluation of motor coordination.Results:In the acetic acid-induced writhing test, the Es-EtOH (100, 200 and 400 mg/kg, i.p.) reduced the number of writhings by 68.59, 79.33 and 65.28%, respectively. Additionally, Es-EtOH (100, 200 and 400 mg/kg, i.p.) decreased by 34.14, 52.61 and 60.97% the paw licking time in the first phase, as well as 89.56, 79.90 and 96.71% in the second phase of the formalin test, respectively. Es-EtOH also showed effect in the hot plate test, since increased the latency time at dose of 100 mg/kg after 60 minutes. In addition, Es-EtOH did not impair motor coordination. The presence of phenolic compounds in the extract was confirmed using HPLC. These results indicate that Es-EtOH has antinociceptive activity, probably of peripheral origin. The mechanism involved is not completely understood but, at least in part there is the participation of opioid receptors.

Denúncias de violência ao idoso no período de 2020 a 2023 na perspectiva da bioética

“…Nesse contexto, a amplitude da população idosa assume uma importância crucial nas políticas públicas e na sociedade em geral. Isso se deve ao fato de que, ao se tornarem mais vulneráveis a alterações no estado de saúde e a dependências para as atividades diárias, eles se tornam mais propensos a situações de violência, aumentando significativamente a probabilidade de internação (Bittencout;Silva, 2018;Almeida;Aguiar, 2011).…”

Hydroalcoholic Extract of Encholirium spectabile Mart. (Bromeliaceae) in O/W Emulsions as an Additive against the UVB Radiation

“…The low toxicity of the compounds present in E. spectabile , associated with the existence of phytosterols, fatty acids, and the strong presence of vitamin E in the leaves emphasize this plant as a nutritional source for humans and animals (7). No reports of the use of E. spectabile in folk medicine have been found in the literature so far; however, pharmacological/biological studies demonstrate that extracts of this plant have antioxidant, photoprotective, antinociceptive, gastroprotective and antibacterial activity against Gram‐positive and Gram‐negative (8–10).…”

Hechtia glomerata Zucc: Phytochemistry and Activity of Its Extracts and Major Constituents Against Resistant Bacteria

“…Because of its vast distribution, it is considered today as the Bromeliad with the largest habitat [9]. In Mexico, there are 426 species of Bromeliaceae [10] and some are widely known, such as pineapple ( Ananas comosus ), and others have already been studied for pharmacological purposes [11,12,13,14,15,16] and part of their composition has already been elucidated [17,18]. H. glomerata is used both as a source of food and in ethnomedicine to treat various infections including bronchitis, laryngitis, nephritis, whooping cough, urethritis, and sepsis [19,20,21,22].…”