Antinociceptive Effect of Chlorogenic Acid in Rats with Painful Diabetic Neuropathy

Bağdaş, Deniz; Ozboluk, Hasret Yucel; Çinkılıç, Nilüfer; Gurun, Mine Sibel

doi:10.1089/jmf.2013.2966

Cited by 28 publications

(22 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is in line with several studies demonstrating that chlorogenic acid inhibits abdominal constrictions induced by acetic acid as well as p-benzoquinone (Chen et al 2013 ; Küpeli et al 2012 ; Li et al 2009 ). Moreover, pure chlorogenic acid reduces pain in neuropathic pain models (Bagdas et al 2013 ; Bagdas et al 2014 ). One of the suggested mechanisms by which chlorogenic acid alleviates pain is inhibition of acid-sensing ion channels in peripheral neurons (Qu et al 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Neuropharmacological characterization of the oneirogenic Mexican plant Calea zacatechichi aqueous extract in mice

et al. 2016

View full text Add to dashboard Cite

This study evaluates the neuropharmacological effects of the aqueous extract of the Mexican plant Calea zacatechichi Schltdl., which is commonly used in folk medicine to treat cough, asthma, and gastrointestinal disorders. Moreover, it has been used for centuries in traditional rituals based on divination and is thought to possess hallucinogenic activity. To test the neuropharmacological effects of the aqueous extract of C. zacatechichi we used mouse models of convulsions, an elevated plus-maze test and measured locomotor activity. We also evaluated the effect of the extract on antidepressant-like behavior in forced swim test, as well as on muscular strength in a grip test. Moreover the antinociceptive action of the extract was evaluated in the hot-plate and writhing tests. The chemical composition of the extract was evaluated using LC-MS techniques. The aqueous extract of C. zacatechichi did not affect any of the parameters measured in seizure models. It had also no influence on anxiety, exploratory behavior and muscular strength in the applied doses. On the other hand, the extract exhibited antinociceptive effect in the mouse model of abdominal pain. Chemical characterization of the extract showed the presence of chlorogenic acid, acacetin, and germacranolides. Based on this report we suggest that aqueous extract of C. zacatechichi has insignificant neuropharmacological effects in vivo and reduces abdominal pain perception. Our results, together with previous studies showing beneficial effects of the extracts obtained from C. zacatechichi suggest that these preparations may be used to treat medical conditions.

show abstract

Section: Discussionmentioning

confidence: 99%

Neuropharmacological characterization of the oneirogenic Mexican plant Calea zacatechichi aqueous extract in mice

et al. 2016

View full text Add to dashboard Cite

show abstract

“…These effects are consistent with an ameliorating effect of CA on the auditory function. Also, using a mechanical claw pressure test, CA was effective to relief DM-induced neuropathic pain, possibly through reducing blood glucose level and alleviating oxidative stress [68].…”

Section: Effects Of Ca On Diabetic Peripheral Neuropathy (Dpn)mentioning

confidence: 99%

Use of Chlorogenic Acid against Diabetes Mellitus and Its Complications

Yan

Zhou²,

Ke³

et al. 2020

Journal of Immunology Research

102

View full text Add to dashboard Cite

Chlorogenic acid (CA) is a phenolic compound commonly found in human plant-based diets. CA is the main component of many traditional Chinese medicine preparations, and in recent years, it has been found to have hypoglycemic, hypolipidemic, anti-inflammatory, antioxidant, and other pharmacological properties. Specifically, CA relieves the effects of, and prevents, diabetes mellitus (DM). In addition, CA is also beneficial against complications arising from DM, such as diabetic nephropathy (DN), diabetic retinopathy (DR), and diabetic peripheral neuropathy (DPN). Herein, we review the use of CA in the prevention and treatment of DM and its complications, providing a background for further research and medical uses.

show abstract

“…The consensus of the literature is that extracts derived from CGA-containing plants produce antinociception in animal models [ 22 - 24 , 93 ]. While pure CGA is not effective for the treatment of acute pain [ 94 ], it may possess antinociceptive activity in tonic and inflammatory pain models, such as formalin- and carrageenan-induced pain [ 17 ] and chronic neuropathic pain models [ 94 - 96 ]. CGA’s effectiveness in chronic neuropathic pain models may be due to CGA’s anti-inflammatory properties.…”

Section: Effects Of Chlorogenic Acid In Inflammatory and Neuropathic mentioning

confidence: 99%

Pharmacologic Overview of Chlorogenic Acid and its Metabolites in Chronic Pain and Inflammation

Bağdaş

Gül

Meade

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background: Natural phenolic compounds in medicinal herbs and dietary plants are antioxidants which play therapeutic or preventive roles in different pathological situations, such as oxidative stress and inflammation. One of the most studied phenolic compounds in the last decade is chlorogenic acid (CGA), which is a potent antioxidant found in certain foods and drinks. Objective: This review focuses on the anti-inflammatory and antinociceptive bioactivities of CGA, and the putative mechanisms of action are described. Ethnopharmacological reports related to these bioactivities are also reviewed. Materials and Methods: An electronic literature search was conducted by authors up to October 2019. Original articles were selected. Results: CGA has been shown to reduce inflammation and modulate inflammatory and neuropathic pain in animal models. Conclusion: The consensus of the literature search was that systemic CGA may facilitate pain management via bolstering antioxidant defenses against inflammatory insults.

show abstract

Antinociceptive Effect of Chlorogenic Acid in Rats with Painful Diabetic Neuropathy

Cited by 28 publications

References 9 publications

Neuropharmacological characterization of the oneirogenic Mexican plant Calea zacatechichi aqueous extract in mice

Neuropharmacological characterization of the oneirogenic Mexican plant Calea zacatechichi aqueous extract in mice

Use of Chlorogenic Acid against Diabetes Mellitus and Its Complications

Pharmacologic Overview of Chlorogenic Acid and its Metabolites in Chronic Pain and Inflammation

Contact Info

Product

Resources

About