Antinociceptive, antipyretic, and anti-inflammatory activities of Putranjiva roxburghii Wall. leaf extract in experimental animals

Abstract

The effects of the ether extract from the leaves of Putranjiva roxburghii (P. roxburghii) Wall. were assessed on nociceptive responses in mice by using writhing, hot plate, and formalin tests and the antipyretic activity was determined in yeast-induced fever in rats. Anti-inflammatory activities were also investigated using carrageenin-induced paw edema in rats and croton oil-induced ear and anus edemas. The ether extract (100, 200, and 400 mg/kg, p.o.) of P. roxburghii dose-dependently produced analgesic activity in acetic acid-induced writhing in mice. The extract had no significant effect in the hot plate test in mice. At the dose of 400 mg/kg, the extract significantly suppressed the licking activity in the late phase of the formalin test in mice and decreased fever induced by yeast in rats. The extract exhibited moderate inhibitory activity of inflammation in carrageenin-induced paw edema in rats. The extract inhibited croton oil-induced ear edema in a dose-dependent manner (1.25, 2.5, and 5.0 mg/ear) in mice. The extract decreased anus edema induced by croton oil at the high dose of 800 mg/kg in rats. The results indicated that the ether extract of P. roxburghii leaves possesses analgesic, antipyretic, and anti-inflammatory activities.

Multi-model confirmatory evaluation of anti-inflammatory, analgesic and antioxidant activities of Putranjiva roxburghii wall

“…In comparison, the ether extract was slightly less potent than Indomethacin on nociceptive response in rats 39 as described by Wantana Reanmongkol et al 2009. These results indicated that the P.roxburghii ethanolic extract may possess significant antinociceptive activity.…”

Some pharmacological studies on the methanolic extract of <i>Inula graveolense</i> L.

“…Fever has been recognized as a major sign of diseased condition right from the very beginning of human civilization. The febrile response is coordinated by the central nervous system through endocrine, neurological, immunological and behavioral mechanisms [27]. The initiation, manifestations and regulation of the febrile response are dependent on the pyrogenic and anti-pyrogenic properties of various exogenous and endogenous substances.…”

Phytochemical Screening, Antioxidant and Cytotoxic Activities in Extracts of Different Rhizome Parts From Curcuma Aeruginosa Roxb.

“…Traditionally, its rhizomes have been used medically to treat colic, obesity and rheumatism, asthma and coughs, scurvy and mental derangement 1 . This plant has been reported to have various pharmacological activities like antioxidant 2 , anti-inflammatory 3 , inhibitory of HIV-1 4 , anti-cancer 5 , and antifungal 6 . The C. aeruginosa rhizome has three levels of different parts, namely the primary rhizome (PR), the secondary rhizome (SR) and tertiary rhizome (TR).…”