Antinociceptive, Anti-Inflammatory and Antipyretic Activities of the Leaf Methanol Extract of &lt;i&gt;Ruta Graveolens&lt;/i&gt; L. (Rutaceae) in Mice and Rats

Loonat, Firdows; Amabeoku, G.J.

doi:10.4314/ajtcam.v11i3.25

Cited by 21 publications

(10 citation statements)

References 29 publications

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“…Many studies reported the anti‐inflammatory activity of Ruta graveolens [35,36] . In a research conducted by Loonat and Amabeoku, [35] the extract of R. graveolens significantly reduced carrageenan‐induced edema.…”

Section: Resultsmentioning

confidence: 99%

Phenolic Content and in Vitro Antioxidant, Anti‐Inflammatory and antimicrobial Evaluation of Algerian Ruta graveolens L.

Mahouachi

Youcefi

Keddari

et al. 2022

Chemistry & Biodiversity

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Plants constitute a valuable source of natural antioxidants such as polyphenols and are responsible for exhibiting many biologically significant functions. Ruta species including Ruta chalepensis L. and Ruta graveolens L. are widespread species in Algeria and are used as medicinal plants to treat various diseases; however, so far, most of the conducted studies focused on analyzing alkaloids and essential oils mostly on R. chalepensis. The aim of the present research is to investigate the phenolic profile of the aerial parts of Ruta graveolens L. from Algeria and assess its in vitro antioxidant, anti-inflammatory and antimicrobial properties. The total polyphenols and flavonoids were assessed using colorimetric methods, and the individual polyphenols were identified and quantified using HPLC-DAD-ESI-MS. The antioxidant activity was evaluated with DPPH and β-carotene tests, and the anti-inflammatory activity with inhibition of bovine serum albumin denaturation and HRBC membrane stabilization methods. The results showed that Ruta graveolens extract is rich in phenolic compounds with a total phenol and flavonoid contents of 41.63 � 0.394 mg GAE/gE and 13.97 � 0.33 mg EQ/gE, respectively. Nine phenolic compounds were determined, including three phenolic acids and six flavonoids. Rutin was the major phenolic compound in Ruta graveolens (464.95 μg/g), followed by syringic acid (179.74 μg/g), and naringenin (109.78 μg/g). R. graveolens phenolic extract also showed good antioxidant activity with values of 0.77 mM TE/g DW and 0.37 mM β-CE/g DW with DPPH and β-carotene tests, respectively. For the anti-inflammatory activity, the highest tested concentration (200 μg/mL) gave 50.61 % of inhibition of the denaturation of albumin and 44.12 % of membrane stabilization. With regards to antimicrobial results, Staphylococcus aureus was the most sensitive bacteria with an inhibition zone of 14.37 mm and MIC value of 0.625 mg/mL, followed by Listeria monocytogenes (11.75 mm and MIC = 1.25 mg/mL), and Escherichia coli (10.25 mm and MIC = 1.25 mg/mL).

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Section: Resultsmentioning

confidence: 99%

Phenolic Content and in Vitro Antioxidant, Anti‐Inflammatory and antimicrobial Evaluation of Algerian Ruta graveolens L.

Mahouachi

Youcefi

Keddari

et al. 2022

Chemistry & Biodiversity

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“…Rue should not be used internally due to toxicity issues. The data obtained by Loonat and Amabeoku (2014), indicated that Ruta graveolens has antinociceptive, anti-inflammatory and antipyretic activities, justifying the use of the plant species by traditional medicine practitioners in the management and treatment of pain, inflammation and fever, indicated the same authors.…”

Section: What Does the Bibliography Say About Garden Cress (Lipidium mentioning

confidence: 86%

The Powerful Healing Effect of Traditional Medicine for The Treatment of Certain Chronic Diseases: One of The Means To Better Defeat Covid-19

Rahal-Bouziane¹

2022

jbarbiomed

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Health is one of the greatest blessings a person can have, and it is priceless. Traditional medicine has always been and remains an important practice for human health. In all regions of the world, popular knowledge has acquired its own experiences in traditional medicine which are passed on from generation to generation and which have generated wonders in terms of innovation of effective traditional remedies which bear the fruit of the healing. After the release of the novel Covid-19 virus, several research studies have focused on the study of medicinal plants that fall under traditional Chinese or Indian medicine or others around the world, to try to put in place remedies against this virus. Chronic Diseases kill millions of people around the world every year. These diseases cause a weakening of the immune system in people who have them. As a result, health experts have classified those affected by these diseases as being among the most at risk in the event of contracting Covid-19. It is therefore obvious that preventing and combating chronic diseases helps to better cope with this Virus or others that may arise in the future. In this humble work, we have tried to make a small contribution that could help fight Covid-19. In the light of actual practices supported by bibliographic research, we try to recall some orientations of natural treatments against certain widespread chronic diseases namely: type 2 diabetes; arthritis and weak immune system (particular case of a low white blood cell count). The results of these treatments are very promising for healing and recovery; which opens doors of hope for those who are affected. Moreover, this subject deserves serious investigations through Research for a better consolidation of these therapies.

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“…The HPLC operating conditions were programmed to give the following: 0 min, solvent B: 20%; 5 min, solvent B: 40%; 15 min, solvent B: 60%; 20 min, solvent B: 80% and 27 min. The run rate was 30 min [ 44 ].…”

Section: Methodsmentioning

confidence: 99%

Protective Effects of Parkia biglobosa Protein Isolate on Streptozotocin-Induced Hepatic Damage and Oxidative Stress in Diabetic Male Rats

et al. 2017

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This study sought to investigate the possible protective role of Parkia biglobosa seed protein isolate (PBPi) against streptozotocin-induced hepatic damage and oxidative stress in diabetic male rats. Prior to animal experiments, a HPLC fingerprint of PBPi was recorded. Diabetes was induced in rats by a single intraperitoneal injection of streptozotocin (STZ; 60 mg/kg body weight). Diabetic rats were orally treated daily with PBPi (200 or 400 mg/kg body weight) or insulin (5 U/kg, i.p.) for 28 days. The degree of protection was evaluated using biochemical parameters such as malondialdehyde (MDA) levels, serum transaminases (ALT and AST), total protein, total glutathione (Total GSH), glutathione-S-transferase (GST), superoxide dismutase (SOD), catalase (CAT), and interleukin-6 (IL-6) activities. Histology of liver sections was also performed. The HPLC fingerprint of PBPi revealed eleven distinct peaks; PBPi at tested doses significantly attenuates STZ-induced elevated levels of serum IL-6, ALT and AST; and hepatic TBARS levels. Hepatic antioxidants (Total GSH, GST, SOD, CAT) as well as total protein were markedly restored in a dose-dependent manner. Histopathological results strongly support the protective role of PBPi. These results suggest PBPi could confer protection by ameliorating hepatic damage and oxidative stress caused by STZ in animal model possibly via its anti-inflammatory and antioxidant properties.

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Antinociceptive, Anti-Inflammatory and Antipyretic Activities of the Leaf Methanol Extract of <i>Ruta Graveolens</i> L. (Rutaceae) in Mice and Rats

Cited by 21 publications

References 29 publications

Phenolic Content and in Vitro Antioxidant, Anti‐Inflammatory and antimicrobial Evaluation of Algerian Ruta graveolens L.

Phenolic Content and in Vitro Antioxidant, Anti‐Inflammatory and antimicrobial Evaluation of Algerian Ruta graveolens L.

The Powerful Healing Effect of Traditional Medicine for The Treatment of Certain Chronic Diseases: One of The Means To Better Defeat Covid-19

Protective Effects of Parkia biglobosa Protein Isolate on Streptozotocin-Induced Hepatic Damage and Oxidative Stress in Diabetic Male Rats

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