Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon “Grosso” essential oil

Barocelli, Elisabetta; Calcina, Francesco; Chiavarini, M.; Impicciatore, M; Bruni, Renato; Bianchi, Alberto; Ballabeni, Vigilio

doi:10.1016/j.lfs.2004.08.008

Cited by 103 publications

(59 citation statements)

References 20 publications

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“…However, it could be related to opioidergic neurotransmission. These findings are in agreement with previous study (Barocelli et al 2004) which showed that treatment with naloxone, an opioid antagonist, prevents the analgesic action of lavender essential oil.…”

Section: Discussionsupporting

confidence: 94%

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Antioxidant, analgesic and anti-inflammatory effects of lavender essential oil

Silva

Luft

Lunardelli

et al. 2015

An. Acad. Bras. Ciênc.

132

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Several studies have investigated the antinociceptive, immunomodulatory and anti-inflammatory properties of compounds found in the lavender essential oil (LEO), however to date, there is still lack of substantial data. The objective of this study was to assess the antioxidant, anti-inflammatory and antinociceptive effects of lavender essential oil. The 1,1-diphenyl-2-picrylhydrazyl radical decolorization assay was used for antioxidant activity evaluation. The anti-inflammatory activity was tested using two models of acute inflammation: carrageenan-induced pleurisy and croton oil-induced ear edema. The antinociceptive activity was tested using the pain model induced by formalin. LEO has antioxidant activity, which is dose-dependent response. The inflammatory response evoked by carrageenan and by croton oil was reduced through the pre-treatment of animals with LEO. In the pleurisy model, the drug used as positive control, dexamethasone, was more efficacious. However, in the ear swelling, the antiedematogenic effect of the oil was similar to that observed for dexamethasone. In the formalin test, LEO consistently inhibited spontaneous nociception and presented a similar effect to that of tramadol. The results of this study reveal (in vivo) the analgesic and anti-inflammatory activities of LEO and demonstrates its important therapeutic potential.

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Section: Discussionsupporting

confidence: 94%

“…The antinociceptive properties of lavender species have been demonstrated by many authors (Hajhashemi et al 2003, Barocelli et al 2004. In this study, we evaluated the antinociceptive effect of Lavandula angustifolia Mill.…”

Section: Discussionmentioning

confidence: 97%

Antioxidant, analgesic and anti-inflammatory effects of lavender essential oil

Silva

Luft

Lunardelli

et al. 2015

An. Acad. Bras. Ciênc.

132

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“…Ironically, literature review on these constituents for their effect on gastric ulcers revealed that some of these constituents and/or their derivatives have been reported for antiulcer/gastro-protective effects and none of these constituents are known for their gastric hypersecretory or ulcerogenic effects. Derivative of 2(5H)-furanone is reported to possess antiulcer effect (Tamai et al, 1993) while cineole, linalool, phytol, and formic acid are reported as possible chemical constituents, responsible for antiulcer effect of plant extracts in which they are found (Barocelli et al, 2004;Haider et al, 2012;Takayama et al, 2011). Carvacrol is reported for antiulcer action (Oliveira et al, 2012;Rao et al, 2004;Silva et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Proulcerogenic effect of water extract ofBoswellia sacraoleo gum resin in rats

Asad

Alhomoud

2015

Pharmaceutical Biology

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Context: The water extract of Boswellia sacra Flueck. (Burseraceae) is used in the treatment of gastric and hepatic disorders in the Arab countries. Objective: The effect of Boswellia sacra water extract on gastric secretion and experimentally induced gastric ulcers in rats was studied. Materials and methods: Acetic acid-induced chronic gastric ulcers, pylorus ligation, aspirininduced, ethanol-induced, and restraint plus cold stress-induced gastric ulcer models were employed. The effect on normal rats was also studied. The water extract of B. sacra was administered orally at doses of 2 and 5 ml/kg once daily ranging from single dose to 30 d treatment depending on the model. The extract was subjected to GC-MS analysis to determine the presence of various phytoconstituents. Results: Boswellia sacra water extract (5 ml/kg, p.o (per os)) aggravated acetic acid-induced chronic ulcers, wherein an increase in ulcer index (p50.01) and ulcer score (p50.05) was observed. In pylorus-ligated rats, the extract increased gastric content volume (p50.01), free acidity (p50.01), total acidity (p50.01), ulcer index (p50.01), and pepsin activity (p50.05). There was no significant effect on the development of ethanol-induced and aspirin-induced ulcers while an increase in the development of stress-induced ulcers was observed (p50.01). The extract did not produce any ulcers when administered to normal rats. The dose of 2 ml/kg was less proulcerogenic compared with 5 ml/kg. The GC-MS analysis revealed the presence of several phytoconstituents that included menthol, 3-cyclohexen-1-ol, and octanoic acid. Conclusion: Boswellia sacra water extract has proulcerogenic activity due to its gastric hypersecretory effect.

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“…It is highly diffused, in the industrialized countries, as an adjuvant treatment in cancer care, for the management of some symptoms of dementia, acute and chronic pain, depression and anxiety [44,45]. This therapy is a natural way of healing a person's mind, body and soul.…”

Section: Medicinal Usementioning

confidence: 99%

The Fascinating History of Bergamot (Citrus Bergamia Risso & Poiteau), the Exclusive Essence of Calabria: A Review

Maruca¹,

Laghetti²,

Mafrica³

et al. 2017

JESE-A

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Abstract:The bergamot (Citrus bergamia Risso et Poiteau), a citrus fruit growing almost exclusively in the South Italy, is considered the "prince of citrus" for its storical role in the perfume industry due to its essential oil, a product in great demand of a pleasant and refreshing scent. Recently, analgesic, anxiolytic, neuroprotective consistent effects have been ascribed to bergamot essential oil when it is used in aromatherapy, for the relief of pain and symptoms associated with stress-induced anxiety and depression. Moreover, today, bergamot fruit due to a considerable abundance and variety of nutraceutical compounds which are present in its juice, is becoming increasingly important also in the food, pharmaceutical and confectionery industries. In this review, it is discussed that the literature on C. bergamia, focusing on the several studies performed with the experimental data, and recently accumulated, may form the rational basis for further development.

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Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon “Grosso” essential oil

Cited by 103 publications

References 20 publications

Antioxidant, analgesic and anti-inflammatory effects of lavender essential oil

Antioxidant, analgesic and anti-inflammatory effects of lavender essential oil

Proulcerogenic effect of water extract ofBoswellia sacraoleo gum resin in rats

The Fascinating History of Bergamot (Citrus Bergamia Risso & Poiteau), the Exclusive Essence of Calabria: A Review

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