Antinociceptive and Anti-Inflammatory Properties of Cannabidiol Alone and in Combination with Standardized Bioflavonoid Composition

Yimam, Mesfin; O’Neal, Alexandria; Horm, Teresa; Jiao, Peng; Rossiter, Shayna; Brownell, Lidia; Jia, Qi

doi:10.1089/jmf.2020.0178

Cited by 7 publications

(9 citation statements)

References 28 publications

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“…CBD has been used in pain management in MS, PD and chronic pain syndromes including LBP. 150 , 151 , 152 , 153 , 154 Signaling through CB2R prevents anti‐oxidative stress, inducing protective anti‐inflammatory and anti‐senescent effects on NP cells, inhibits IVDD in‐vitro and in‐vivo in a rat acupuncture model and human IVD. Activation of CB2R suppresses MMP‐9, 13, induces type II collagen and SOX‐9 (SRY‐box transcription factor‐9) expression restoring ECM integrity through the AMPK/GSK3β pathway.…”

Section: Ivdd Establishment Of Nociceptor and Mechano‐recep...mentioning

confidence: 99%

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Intervertebral disc degeneration and how it leads to low back pain

Diwan

Melrose

2022

JOR Spine

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The purpose of this review was to evaluate data generated by animal models of intervertebral disc (IVD) degeneration published in the last decade and show how this has made invaluable contributions to the identification of molecular events occurring in and contributing to pain generation. IVD degeneration and associated spinal pain is a complex multifactorial process, its complexity poses difficulties in the selection of the most appropriate therapeutic target to focus on of many potential candidates in the formulation of strategies to alleviate pain perception and to effect disc repair and regeneration and the prevention of associated neuropathic and nociceptive pain. Nerve ingrowth and increased numbers of nociceptors and mechanoreceptors in the degenerate IVD are mechanically stimulated in the biomechanically incompetent abnormally loaded degenerate IVD leading to increased generation of low back pain. Maintenance of a healthy IVD is, thus, an important preventative measure that warrants further investigation to preclude the generation of low back pain. Recent studies with growth and differentiation factor 6 in IVD puncture and multi‐level IVD degeneration models and a rat xenograft radiculopathy pain model have shown it has considerable potential in the prevention of further deterioration in degenerate IVDs, has regenerative properties that promote recovery of normal IVD architectural functional organization and inhibits the generation of inflammatory mediators that lead to disc degeneration and the generation of low back pain. Human clinical trials are warranted and eagerly anticipated with this compound to assess its efficacy in the treatment of IVD degeneration and the prevention of the generation of low back pain.

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Section: Ivdd Establishment Of Nociceptor and Mechano‐recep...mentioning

confidence: 99%

“…Activation of CB2R suppresses MMP‐9, 13, induces type II collagen and SOX‐9 (SRY‐box transcription factor‐9) expression restoring ECM integrity through the AMPK/GSK3β pathway. 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 , 156 …”

Section: Ivdd Establishment Of Nociceptor and Mechano‐recep...mentioning

confidence: 99%

Intervertebral disc degeneration and how it leads to low back pain

Diwan

Melrose

2022

JOR Spine

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“…CBD acts through the cannabinoid CB1 and CB‐2 receptors, three G protein coupled‐receptors (adenosine receptor subtype 2A, serotonin receptor subtype 1A and G protein‐coupled receptor 55), one ligand‐gated ion channel (transient receptor potential vanilloid channel‐1, TRPV‐1) and one nuclear factor (peroxisome proliferator‐activated receptor γ, PPAR). CBD has been used in the management of epilepsy, 353 , 354 Alzheimer's disease, 355 pain alleviation in MS, 307 neurological responses in Parkinson's disease, 308 , 313 chronic pain 305 , 306 , 309 , 312 including LBP. 311 CBD has been evaluated in a double blind randomized clinical trial for the relief of central neuropathic pain in MS. 307 …”

Section: Anti‐inflammatory Phytochemicals Displaying Ivd ...mentioning

confidence: 99%

An update on animal models of intervertebral disc degeneration and low back pain: Exploring the potential of artificial intelligence to improve research analysis and development of prospective therapeutics

et al. 2023

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Animal models have been invaluable in the identification of molecular events occurring in and contributing to intervertebral disc (IVD) degeneration and important therapeutic targets have been identified. Some outstanding animal models (murine, ovine, chondrodystrophoid canine) have been identified with their own strengths and weaknesses. The llama/alpaca, horse and kangaroo have emerged as new large species for IVD studies, and only time will tell if they will surpass the utility of existing models. The complexity of IVD degeneration poses difficulties in the selection of the most appropriate molecular target of many potential candidates, to focus on in the formulation of strategies to effect disc repair and regeneration. It may well be that many therapeutic objectives should be targeted simultaneously to effect a favorable outcome in human IVD degeneration. Use of animal models in isolation will not allow resolution of this complex issue and a paradigm shift and adoption of new methodologies is required to provide the next step forward in the determination of an effective repairative strategy for the IVD. AI has improved the accuracy and assessment of spinal imaging supporting clinical diagnostics and research efforts to better understand IVD degeneration and its treatment. Implementation of AI in the evaluation of histology data has improved the usefulness of a popular murine IVD model and could also be used in an ovine histopathological grading scheme that has been used to quantify degenerative IVD changes and stem cell mediated regeneration. These models are also attractive candidates for the evaluation of novel anti‐oxidant compounds that counter inflammatory conditions in degenerate IVDs and promote IVD regeneration. Some of these compounds also have pain‐relieving properties. AI has facilitated development of facial recognition pain assessment in animal IVD models offering the possibility of correlating the potential pain alleviating properties of some of these compounds with IVD regeneration.

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“…In a rat model of knee osteoarthritis (OA), topical application of CBD was associated with reduced pain and inflammation [ 18 ]. In a study of rodent inflammatory and non-inflammatory pain models, high doses (5–40 mg/kg) of CBD alone or in combination with standardized bioflavonoid compositions, either orally administered or applied topically, provided pain reduction [ 19 ].…”

Section: Recent Preclinical Evidence For Cbd Effects In Rheumatic Com...mentioning

confidence: 99%

Cannabidiol (CBD) in Rheumatic Diseases (Musculoskeletal Pain)

2022

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Purpose of Review This review will address the many uncertainties surrounding the medical use of cannabidiol (CBD). We will begin with an overview of the legal and commercial environment, examine recent preclinical and clinical evidence on CBD, explore questions concerning CBD raised by healthcare professionals and patients, investigate dosing regimens and methods of administration, and address current challenges in the accumulation of sound evidence. Recent Findings CBD has potential for relief of symptoms of pain, sleep, and mood disturbance in rheumatology patients, but sound clinical evidence is lacking. CBD is safe when accessed from a regulated source, whereas wellness products are less reliable regarding content and contaminants. Dosing for symptom relief has not yet been established. Summary As many rheumatology patients are trying CBD as a self-management strategy, the healthcare community must urgently accrue sound evidence for effect.

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Antinociceptive and Anti-Inflammatory Properties of Cannabidiol Alone and in Combination with Standardized Bioflavonoid Composition

Cited by 7 publications

References 28 publications

Intervertebral disc degeneration and how it leads to low back pain

Intervertebral disc degeneration and how it leads to low back pain

An update on animal models of intervertebral disc degeneration and low back pain: Exploring the potential of artificial intelligence to improve research analysis and development of prospective therapeutics

Cannabidiol (CBD) in Rheumatic Diseases (Musculoskeletal Pain)

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