Antinociceptive and anti-inflammatory effects of Rhodiola Rosea L. extract in rats

Doncheva, N.; Bakova, Desislava; Getova, D.

doi:10.2478/folmed-2013-0030

Cited by 11 publications

(13 citation statements)

References 9 publications

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“…In the formalin test, only 100 mg/kg R. rosea could decrease the paw licking time in early reaction. In plethysmometer test, R. rosea exhibited significant anti‐inflammatory activity at both dosage but time‐dependently . Another pharmacological research using 40% ethanol extract of R. rosea (Extract 54 ) revealed its anti‐inflammatory activities against acute and subacute inflammation at the dosage of 250 mg/kg.…”

Section: Pharmacological Activitiesmentioning

confidence: 97%

“…In plethysmometer test, R. rosea exhibited significant anti-inflammatory activity at both dosage but time-dependently. 167 Another pharmacological research using 40% ethanol extract of R. rosea (Extract 54) revealed its anti-inflammatory activities against acute and subacute inflammation at the dosage of 250 mg/kg. Meanwhile, it also exhibited an inhibitory effect on nystatin-induced edema under a dose-dependent manner (50,150, and 250 mg/kg), which might be associated with its inhibitory activities over cyclooxygenase-1 (COX-1), COX-2, and phospholipase A2.…”

Section: Anti-inflammatory and Analgesic Activitiesmentioning

confidence: 99%

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Rhodiola species: A comprehensive review of traditional use, phytochemistry, pharmacology, toxicity, and clinical study

Tao

Cao

et al. 2019

Medicinal Research Reviews

106

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Rhodiola species, belonging to the family Crassulaceae, have long been used as an adaptogen, tonic, antidepressant, and antistress medicine or functional food in Asia and Europe. Due to the valuable application, the growing demand of Rhodiola species has led to a rapid decrease in resource content. This review aims to summarize the integrated research progress of seven mainstream Rhodiola species. We first outline both traditional and current use of Rhodiola for the treatment of various diseases. A detailed summary and comparison of chemical, pharmacological, toxicological, and clinical studies of various Rhodiola species highlight recent scientific advances and gaps, which gives insights into the understanding of Rhodiola application and would be helpful to improve the situation of biological resources and diversities of Rhodiola plants.

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Section: Pharmacological Activitiesmentioning

confidence: 97%

Section: Anti-inflammatory and Analgesic Activitiesmentioning

confidence: 99%

Rhodiola species: A comprehensive review of traditional use, phytochemistry, pharmacology, toxicity, and clinical study

Tao

Cao

et al. 2019

Medicinal Research Reviews

106

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“…The pharmacological effects of RRL preparations are attributed to the phenylpropanoids, organic acids, and flavonoids extracted from the roots and rhizomes. RRL preparations exhibit adaptogenic effects, including neuroprotective, cardioprotective, anti-fatigue, anti-depressive, anxiolytic [ 12 ], nootropic, hepatoprotective, anti-allergic, anti-cancer, and life-span increasing effects, as well as central nervous system stimulating [ 13 , 14 , 15 ], anti-nociceptive, and anti-inflammatory activities [ 16 , 17 ]. These earlier studies mainly focused on the anti-inflammatory and anti-apoptotic/pro-apoptotic effects of salidroside in lung tissues and/or cells but not on its anti-fibrotic potential.…”

Section: Introductionmentioning

confidence: 99%

Preventive Effects of Rhodiola rosea L. on Bleomycin-Induced Pulmonary Fibrosis in Rats

Zhang

Si²,

Huang

et al. 2016

IJMS

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Rhodiola rosea L. (RRL) possesses a wide range of pharmacological properties, including lung-protective activity, and has been utilized in folk medicine for several 100 years. However, the lung-protective mechanism remains unclear. This study investigated the possible lung-protective activity mechanism of RRL in a pulmonary fibrosis (PF) rat model. Lung fibrotic injury was induced in Sprague–Dawley rats by single intratracheal instillation of saline containing bleomycin (BLM; 5 mg/kg). The rats were administered 125, 250, or 500 mg/kg of a 95% ethanol extract of RRL for 28 days. The animals were killed to detect changes in body weight, serum levels of glutathione (GSH) and total superoxide dismutase (T-SOD), as well as lung tissue hydroxyproline (HYP) content. Tumor necrosis factor-α (TNF-α), transforming growth factor-β1 (TGF-β1), and interleukin 6 (IL-6) levels were measured in bronchoalveolar lavage fluid (BALF) by enzyme-linked immunosorbent assay. Hematoxylin and eosin, Masson’s trichrome, and immunohistochemical staining were performed to observe the histopathological changes in lung tissues. Additionally, target-related proteins were measured by Western blotting. RRL alleviated the loss of body weight induced by instilling BLM in PF rats, particularly at the 500 mg/kg per day dose. RRL reduced HYP (p < 0.01) and increased GSH and T-SOD contents. BALF levels of TNF-α, TGF-β1, and IL-6 decreased significantly in the RRL-treated groups. Expression levels of matrix metalloproteinase-9 (MMP-9) and α-smooth muscle actin decreased significantly in a dose-dependent manner in response to RRL. Moreover, the levels of TGF-β1 and tissue inhibitor of metalloproteinase-1 in lung tissues also decreased in the RRL-treated groups. RRL alleviated BLM-induced PF in rats. Our results reveal that the protective effects of RRL against fibrotic lung injury in rats are correlated with its anti-inflammatory, antioxidative, and anti-fibrotic properties. MMP-9 may play important roles in BLM-induced PF.

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“…Preclinical studies have reported that RRE has anti-stress, neuropsychotropic, anxiolytic, antidepressant and neuroprotective effects [17,18]. In addition, Rhodiola rosea extract has antioxidant and anti-inflammatory effects [19,20]. No information was found in the literature about the effects of RRE in the treatment of stress-induced infertility and pathologies affecting reproductive processes.…”

Section: Introductionmentioning

confidence: 99%

The effect of rhodiola rosea root extract on stress-induced ovarian damage, infertility and reproductive disorders in female rats

Kadıoğlu¹,

Gündoğdu²,

Kurt³

et al. 2020

Clinical and Experimental Obstetrics & Gynecology

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The aim of the study was to examine the possible effect of Rhodiola rosea root extract (RRE) on ovarian damage, infertility (IF), delay in conception (DC), decrease in the number of offspring (NO) in female rats that have been stressed with compulsory immobilization method (CIM) and on retardation of intrauterine physical development (IPD) in offspring. Materials and methods: Female Albino Wistar rats were divided like: healthy (HG), stress-induced control (SC), and stress + 50 mg/kg RRE (S + REG) groups including sixteen rats in each group. Six rats from each group were killed for conducting biochemical and histopathological examinations in ovarian tissues and others were observed for IF, DC, NO, and IPD. Results: It was found that RRE significantly prevented the increase in oxidative parameters and proinflammatory cytokine levels in ovarian tissue of animals stressed with CIM. RRE suppressed the increase in IF rate and DC whereas caused a decrease in NO and in IPD retardation. Conclusion: These results suggested RRE may have beneficial effects in the treatment of stress induced reproductive dysfunction. Content: The effect of RRE on oxidative and inflammatory changes in ovarian tissue and reproductive changes of animals exposed to stress with compulsory immobilization method.

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Antinociceptive and anti-inflammatory effects of Rhodiola Rosea L. extract in rats

Cited by 11 publications

References 9 publications

Rhodiola species: A comprehensive review of traditional use, phytochemistry, pharmacology, toxicity, and clinical study

Rhodiola species: A comprehensive review of traditional use, phytochemistry, pharmacology, toxicity, and clinical study

Preventive Effects of Rhodiola rosea L. on Bleomycin-Induced Pulmonary Fibrosis in Rats

The effect of rhodiola rosea root extract on stress-induced ovarian damage, infertility and reproductive disorders in female rats

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