Antinociceptive and anti-inflammatory activity of a flavonoid isolated from Caralluma attenuata

Ramesh, M.; Rao, Y Nageshwar; Rao, A. S.; Prabhakar, M. C.; Rao, C. S.; Muralidhar, N; Reddy, B Madahava

doi:10.1016/s0378-8741(98)00048-8

Cited by 120 publications

(71 citation statements)

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“…These compounds exhibit known pharmacological activities, such as anti-inflammatory and antinociceptive (Ramesh et al, 1998;Toker et al, 2004;Kupeli & Yesilada, 2007;Aquila et al, 2009;Dong et al, 2010); antioxidant and cytotoxic effects (Heim et al, 2002;Susant et al, 2007;Dong et al, 2010). Thus, pharmacological activities displayed by PnSDE seem to be related to the presence of flavonoids, especially quercetin (Soares et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and antinociceptive activities of Phyllanthus niruri spray-dried standardized extract

Porto¹,

Soares²,

Souza³

et al. 2013

Rev. bras. farmacogn.

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Phyllanthus niruri L., Euphorbiaceae, spray-dried standardized extract was studied for its anti-infl ammatory and antinociceptive activities in adult albino rats and mice. The anti-infl ammatory effect of spray-dried standardized extract was observed in carrageenan-induced paw edema and thioglycolate-induced leukocyte migration, while antinociceptive effects were observed using Randall & Selitto, tail fl ick, and hot plate tests. This study showed that intraperitoneal spray-dried standardized extract at 100, 200, 800, or 1600 mg/kg reduced the vascular response in the infl ammatory process of paw edema induced by 1% carrageenan. Oral spray-dried standardized extract at 100 or 200 mg/kg inhibited leukocyte migration to the site of infl ammation induced by 3% thioglycolate. In rats, at 100 and 200 mg/kg intraperitoneally, the extract exhibited a marked peripheral analgesic effect in a Randall & Selitto assay and showed signifi cant central analgesic activity in a hot plate and tail fl ick assay. In conclusion, this study suggested that Phyllanthus niruri spray-dried standardized extract has potent infl ammatory and antinociceptive activities and that these activities are not modifi ed by standard drying process, making it feasible to use the dry extract standardized to obtain a phytotherapic preparation and thus validating its use for the treatment of pain and infl ammation disorders.

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Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and antinociceptive activities of Phyllanthus niruri spray-dried standardized extract

Porto¹,

Soares²,

Souza³

et al. 2013

Rev. bras. farmacogn.

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“…Therefore, it is assumed that these compounds may be responsible for the observed analgesic activity. Because flavonoids were reported to have a role in analgesic activity primarily by targeting prostaglandins (Rajnarayana et al 2001;Rao et al, 1998; [23,24,25]. There are also reports on the role of tannins in anti-nociceptive activity ( Vanu et al, 2006) [26].…”

Section: Discussionmentioning

confidence: 99%

In Vivo Assay of Analgesic Activity of Methanolic and Petroleum Ether Extracts of Vitex Negundo Leaves

2013

IOSR-JPBS

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“…Flavonoids, for example, were detected in all the assayed Vitex cymosa extracts (VD, VA and VB). Several studies have reported the antinociceptive effects of flavonoids (Thirugnanasambantham et al, 1990;Pathak et al, 1991;Ramesh et al, 1998;Toker et al, 2004), and, of particular interest is that one reporting the antinociceptive activity of luteolin (Block et al, 1998), which was isolated from VD extract. The antinociceptive activity of this flavonoid has been evaluated by Block et al (1998) in the acetic acid-induced abdominal constriction model in mice.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical profile and analgesic evaluation of Vitex cymosa leaf extracts

Leitão¹,

Santos²,

Monachè³

et al. 2011

Rev. bras. farmacogn.

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Abstract:Vitex cymosa Bertero ex Spreng., Lamiaceae, is found in Central and Amazon regions of Brazil, where it is popularly used as antirheumatic. Extracts from the leaves of V. cymosa were tested in analgesia models such as abdominal contortions induced by acetic acid and formalin to test peripheral analgesia; as well as the tail flick and hot plate models, to test spinal and supraspinal analgesia. A significant reduction was observed in the number of contortions with all extracts and in all doses. In the formalin model, a reduction in the second phase (inflammatory) was observed with all extracts, whereas only the n-butanol extract was able to act in the first, neurogenic, phase. In the tail flick model, all extracts increased latency time. Naloxone treatment reverted analgesic effect of all extracts with the exception of the dichloromethane one. All extracts developed peripheral and central analgesic activity. In the hot plate model no antinociceptive effect was observed for all tested extracts. All these results taken together suggest that V. cymosa leaf extracts were able to promote peripheral and central antinociceptive activity mediated by the opioid system.Twenty three substances were isolated and identified in the extracts and include flavonoids (C-glucosyl flavones, flavones and flavonols), triterpene acids from ursane and oleanane types, iridoids (free and glucosides), as well as simple phenols.

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Antinociceptive and anti-inflammatory activity of a flavonoid isolated from Caralluma attenuata

Cited by 120 publications

References 1 publication

Anti-inflammatory and antinociceptive activities of Phyllanthus niruri spray-dried standardized extract

Anti-inflammatory and antinociceptive activities of Phyllanthus niruri spray-dried standardized extract

In Vivo Assay of Analgesic Activity of Methanolic and Petroleum Ether Extracts of Vitex Negundo Leaves

Phytochemical profile and analgesic evaluation of Vitex cymosa leaf extracts

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