Antinociceptive and anti-inflammatory activity of DW-1021, the ionic complex of pelubiprofen and tramadol, in rodents

Yoon, Youngsook; Hwang, Han-Jun; Kim, Jae-Min; Chung, Kyung‐Sook; Jang, Seo-Yun; Heo, So-Won; Lee, Su-Yeon; Kim, Soo-Yeon; Song, Hyeon-A; Hong, Seung‐Jae; An, Hyo‐Jin; Park, Sang-Wook; Im, Jhong-Jae; Oh, Dongho; Lee, Ah-Ram; Lee, Kyung‐Tae

doi:10.1016/j.biopha.2023.114708

Cited by 1 publication

(1 citation statement)

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“…The most commonly prescribed medications for pain associated with osteoarthritis are nonsteroidal anti-inflammatory drugs and opioid pain relievers. Several studies have highlighted safety concerns related to the long-term use of oral nonsteroidal anti-inflammatory drugs, such as hepatotoxicity, nephrotoxicity, increased risk of hypertension, and other cardiovascular events, as well as multiple adverse effects on the upper gastrointestinal tract (Iolascon et al, 2021 ; Lam et al, 2019 ; Wanchoo et al, 2017 ; Yoon et al, 2023 ; Frantz et al, 2018 ). Therefore, it is crucial to identify a pharmaceutical agent that offers improved safety and effectiveness in the treatment of osteoarthritis.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the mechanism of curcumin against osteoarthritis using metabolomics and transcriptomics

Deng,

He,

Zhang

2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Curcumin, a polyphenolic compound derived from the turmeric plant (Curcuma longa), has been extensively studied for its anti-inflammatory and anti-proliferative properties. The safety and efficacy of curcumin have been thoroughly validated. Nevertheless, the underlying mechanism for treating osteoarthritis remains ambiguous. This study aims to reveal the potential mechanism of curcumin in treating osteoarthritis by using metabolomics and transcriptomics. Firstly, we validated the effect of curcumin on inflammatory factors in human articular chondrocytes. Secondly, we explored the cellular metabolism mechanism of curcumin against osteoarthritis using cell metabolomics. Thirdly, we assessed the differences in gene expression of human articular chondrocytes through transcriptomics. Lastly, to evaluate the essential targets and elucidate the potential mechanism underlying the therapeutic effects of curcumin in osteoarthritis, we conducted a screening of the proteins within the shared pathway of metabolomics and transcriptomics. Our results demonstrated that curcumin significantly decreased the levels of inflammatory markers, such as IL-β, IL-6, and TNF-α, in human articular chondrocytes. Cell metabolomics identified 106 differential metabolites, including beta-aminopropionitrile, 3-amino-2-piperidone, pyrrole-2-carboxaldehyde, and various other components. The transcriptomic analysis yielded 1050 differential mRNAs. Enrichment analysis showed that the differential metabolites and mRNAs were significantly enriched in seven pathways, including glycine, serine, and threonine metabolism; pentose and glucuronate interconversions; glycerolipid metabolism; histidine metabolism; mucin-type o-glycan biosynthesis; inositol phosphate metabolism; and cysteine and methionine metabolism. A total of 23 key targets were identified to be involved in these pathways. We speculate that curcumin may alleviate osteoarthritis by targeting key proteins involved in glycine, serine, and threonine metabolism; inhibiting pyruvate production; and modulating glycolysis.

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