Antinociceptive and anti-edema properties of the ethyl acetate fraction obtained from extracts of Coriandrum sativum Linn. leaves

Begnami, Andreza Fabiana; Spindola, Humberto M.; Ruiz, Ana Lúcia Tasca Góis; Carvalho, João Ernesto de; Groppo, Francisco Carlos; Rehder, Vera Lúcia Garcia

doi:10.1016/j.biopha.2018.04.196

Cited by 23 publications

(20 citation statements)

References 30 publications

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“…When using a 60 min period between treatment and formalin injection, the extract and MvRL‐rich fraction, at all doses investigated, promoted analgesia in the first phase, while the antinociceptive effect in the second phase was detected only with the extract at 400 mg/kg and the fraction at 50 and 100 mg/kg (Figure 4). The effects demonstrated by the extract (400 mg/kg) and fraction (100 mg/kg) in the first phase were reversed by naloxone (Figure 4), an opioid antagonist, indicating an action via opioid receptors known to be present at peripheral nerve endings [37,38] . However, the antinociceptive effects observed during the second phase were not reversed by naloxone.…”

Section: Resultsmentioning

confidence: 94%

“…Neurogenic pain in phase 1 (0–5 min) of the formalin test is triggered by the high concentration of substance P in the central nervous system, while inflammatory pain in phase 2 (15–30 min) is attributed to the release of mediators and medullary sensitization [37] . Preliminary assay indicated that no effect was observed when extract and fraction were administered 30 min before formalin injection (data not shown).…”

Section: Resultsmentioning

confidence: 98%

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Antinociceptive and Anti‐Inflammatory Effects of Saline Extract and Lectin‐Rich Fraction from Microgramma vacciniifolia Rhizome in Mice

Silva

Oliveira

Freitas

et al. 2021

Chemistry & Biodiversity

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Previous studies have characterized a saline extract from Microgramma vacciniifolia rhizome and its lectin (MvRL)‐rich fraction with low acute toxicity. In the present study, we evaluated these preparations for acute toxicity (1,000 mg/kg) and antinociceptive and anti‐inflammatory activities (100–400 mg/kg for the extract and 25–50 mg/kg for the fraction). No signs of toxicity were observed. Both the extract and fraction increased the latency period for nociception in the hot plate assay, decreased writhing induced by acetic acid, and promoted analgesic effects in phases 1 and 2 of the formalin test. The antinociceptive mechanism was attributed to interactions with opioid receptors and K+ ATPase channels. The extract and fraction decreased carrageenan‐induced paw edema in 46.15 % and 77.22 %, respectively, at the highest doses evaluated. Furthermore, the fraction was shown to act on the bradykinin pathway. The ability to decrease leukocyte migration after treatment was also verified in the peritonitis and air pouch models. In exudates collected from air pouches, decreased tumor necrosis factor (TNF)‐α and increased interleukin (IL)‐10 levels were noted. Both the extract and fraction also effectively inhibited the development of granulomatous tissue. In conclusion, the substances investigated in this study can be used for the development of novel therapeutic options for pain and inflammatory processes.

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Section: Resultsmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 98%

Antinociceptive and Anti‐Inflammatory Effects of Saline Extract and Lectin‐Rich Fraction from Microgramma vacciniifolia Rhizome in Mice

Silva

Oliveira

Freitas

et al. 2021

Chemistry & Biodiversity

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“…The pain sensation in acetic acid-induced writhing is due to local inflammatory response resulting from the release of endogenous mediators that stimulate the peripheral nociceptive neurons. In mice, it promotes an increase in the levels of prostaglandins (PGE2 and PGF2α) and lipoxygenase products as well as serotonin and histamine and the release of bradykinin and cytokines (tumor necrosis factor-α and interleukin-1β) ( 15 , 27 , 32 ).…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and antinociceptive effects of the isatin derivative (Z)-2-(5-chloro-2-oxoindolin-3-ylidene)-N-phenyl-hydrazinecarbothioamide in mice

Dantas

Fonseca

Pereira

et al. 2020

Braz J Med Biol Res

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Several isatin derivatives have shown important biological activities, which have attracted interest from researchers. For this reason, the present study aimed to evaluate the anti-inflammatory and antinociceptive effects of the isatin derivative (Z)-2-(5-chloro-2-oxoindolin-3-ylidene)-N-phenyl-hydrazinecarbothioamide (COPHCT) in mice. Three doses of this compound were tested: 1.0, 2.5, and 5.0 mg/kg. The anti-inflammatory activity was assessed using the carrageenan-induced paw edema model and the zymosan-induced air pouch model. The evaluation of the antinociceptive effect was performed through the formalin test and the acetic acid-induced abdominal writhing test. The paw edema assay demonstrated that all doses of the compound showed a significant reduction of the edema in the second hour evaluated, but a better response was observed in the fourth hour. The zymosan-induced air pouch model indicated that the compound, in all doses, significantly reduced leukocyte migration and total protein concentration levels. In the formalin test, the doses 1.0, 2.5, and 5.0 mg/kg of COPHCT showed activity only in the second phase, with reduction in paw pain time of 73.61, 79.46, and 73.85%, respectively. The number of abdominal writhings decreased with the increasing dose, but only 5.0 mg/kg COPHCT exhibited a significant response, with a reduction of 24.88%. These results demonstrated the ability of this compound to interfere in the anti-inflammatory activity of edema, vascular permeability, and cell migration. In addition, its possible antinociceptive effect may be related to the dose used.

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“…Potentilla anserina (Rosaceae) is traditional medicinal plant available in India and Northern hemispheres often on river shores and grassy habitats. Plants which are reported to have antiinflammatory and antinociception activity include Syzygium cerasoideum 3 , Potentilla reptans 4 , Inula britannica 5 , Coriandrum sativum 6 , Clinacanthus nutans 7 , Borreria verticillata 8 , Sonchus asper 9 , Inula helenium 10 , Erigeron acer 11 , Rhus coriaria 12 , Ducrosia anethifolia 13 , Eryngium pyramidal Boiss 14 , Pimpinella anisum 15 , Tanacetum balsamita 16 , Echinophora platyloba 17 and Lemon verbena 18, etc. There is a growing interest in the pharmacological evaluation of various plants used in traditional Indian systems of medicine.…”

Section: (4)1760-64mentioning

confidence: 99%

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2019

IJPSR

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Potentilla anserina (Rosaceae) is a traditional medicinal plant in India, and it is available throughout the Northern hemisphere. This study was intended to evaluate the antinociceptive activity of methanolic extract of Potentilla anserina in acetic acid-induced writhing test in mice and Eddy's Hot Plate method in Albino rats at the dose level of 75, 150 and 300 mg/kg p.o and the study was compared with the standard drug Indomethacin 10 mg/kg. The data were expressed as mean ± S.E.M. The statistical analysis was done using ANOVA followed by Dunnett"s post hock test. The methanolic extract of Potentilla anserina showed significant antinociceptive activity in the acetic acid-induced writhing method the PAME (75, 150, 300 mg/kg, p.o) 1hr before a pain stimulus significantly reduced the nociceptive response. In the hot plate method, there was no significant difference in nociceptive behavior. The antinociceptive activity could be associated with the presence of several flavonoid-based bioactive compounds and their synergistic action with non-volatile bioactive compounds.

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Antinociceptive and anti-edema properties of the ethyl acetate fraction obtained from extracts of Coriandrum sativum Linn. leaves

Cited by 23 publications

References 30 publications

Antinociceptive and Anti‐Inflammatory Effects of Saline Extract and Lectin‐Rich Fraction from Microgramma vacciniifolia Rhizome in Mice

Antinociceptive and Anti‐Inflammatory Effects of Saline Extract and Lectin‐Rich Fraction from Microgramma vacciniifolia Rhizome in Mice

Anti-inflammatory and antinociceptive effects of the isatin derivative (Z)-2-(5-chloro-2-oxoindolin-3-ylidene)-N-phenyl-hydrazinecarbothioamide in mice

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