Antinociceptive activity of the methanol extracts of leaves of Eugenia fruticosa (Roxb.) and Glycosmis pentaphylla (Retz.) in Swiss albino mice

Abstract

The present study was designed to evaluate analgesic potential of the methanolic extracts of the leaves of the both Glycosmis pentaphylla (Rutaceae) and Eugenia fruticosa (Myrtaceae). The analgesic activity was evaluated using the acetic acid (0.7% i.p.)-induced writhing inhibition method in swiss albino mice. The methanolic extract of leaves of Glycosmis pentaphylla, at the dose of 200 and 400 mg/kg body weight significantly (p<0.001) reduced the number of writhes with 31.97% and 44.21% of inhibition, respectively compared to control group. The methanolic extracts of leaves of Eugenia fruticosa significantly and dose dependently reduced the pain threshold (p<0.001) with 51.02 and 72.1% of writhing inhibition when compared to the control group at the dose of 200 and 400 mg/kg body weight, respectively which were comparable to that of the standard drug Diclofenac Na (65.31% inhibition of writhing, p<0.001). The results of the study demonstrated the potential antinociceptive activity of the methanolic extracts of the leaves of Glycosmis pentaphylla and Eugenia fruticosa which validated the traditional uses of the both plants in painful diseases and further investigations to elucidate the mechanism of action are required.

Ethnomedicinal uses, phytochemistry, pharmacological activities and toxicological profile of Glycosmis pentaphylla (Retz.) DC.: A review

“…The methanol extract of G. pentaphylla administered at doses of 200 and 400 mg/kg body weight inhibited the acetic acid-induced writhing in mice by 31.97 and 44.21%, respectively, compared to the standard diclofenac (50 mg/kg dose) which reduced writhes by 65.31% (Shams- Ud-Doha et al, 2012). Another similarly designed study reported 36.54 and 57.70% reductions in writhing counts for the methanol extract at doses of 250 and 500 mg/kg body weight, indicating prominent dose-dependent analgesic property for the extract (Sarkar et al, 2013).…”

Isolation, Characterization of Undescribed Alkaloids, and Semisynthetic Modifications of Cytotoxic Pyranoacridone Alkaloids from Glycosmis pentaphylla

“…G. pentaphylla is a perennial shrub indigenous to the tropical and subtropical regions of China, India, Sri Lanka, Bangladesh, Indonesia, Myanmar, Malaysia, Thailand, the Philippines, Java, Vietnam, Sumatra, Borneo, and Australia. , These plants are traditionally used to treat a variety of ailments including rheumatism, urinary tract infections, chest pain, anemia, cough, liver disorders, inflammation, pain, fever, jaundice, bronchitis, bone fractures, toothache, gonorrhea, diabetes, cancer, and other chronic diseases. , An extensive literature search on phytochemistry of G. pentaphylla revealed that various parts of this plant were reported to contain at least 354 secondary metabolites such as acridone, carbazole, quinolone, and quinazoline types of alkaloids, flavonoids, phenolic glycosides, quinones, furoquinolines, terpenoids, steroids, sulfur-containing amides, gums, reducing sugars, tannins, saponins, and fatty derivatives .…”

Mitigation of apoptosis-mediated neurotoxicity induced by silver nanoparticles via rutaceae nutraceuticals: P53 activation and Bax/Bcl-2 regulation

“…Glycosmis pentaphylla ( G. pentaphylla ) is a flowering small plant or evergreen shrub belongs to Rutaceae family. It is mainly found in East as well as Southeast Asia [24] . Numerous active constituents were identified in G. pentaphylla such as arborine, flavonoids, terpenoids, alkaloids, coumarins, amides and imides [25] , [26] .…”