Antinociceptive activity of methanol extract of fruits of Capparis ovata in mice

Arslan, Rana; Bektaş, Nurcan; Öztürk, Yusuf

doi:10.1016/j.jep.2010.05.060

Cited by 63 publications

(64 citation statements)

References 21 publications

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“…And the reference compound of quercetin in the ETL also with the antioxidant and anti-inflammatory activities (Table 1). Triterpenoid, flavonoids, and phenolic acids possessed analgesic and anti-inflammatory effects on animal models and the pharmacological effects (Arslan et al, 2010). Studies have also demonstrated that flavonoids such as rutin, quercetin, luteolin produced significant antinociceptive and anti-inflammatory activities (Deliorman et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Antioxidant, analgesic, and anti-inflammatory activities of the ethanolic extracts of Taxillus liquidambaricola

Deng

Chi

Huang

et al. 2011

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

Antioxidant, analgesic, and anti-inflammatory activities of the ethanolic extracts of Taxillus liquidambaricola

Deng

Chi

Huang

et al. 2011

Journal of Ethnopharmacology

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“…Also, C. ovata suppresses paw edema by decreasing COX in mice. Moreover, its analgesic activity has been confirmed in an animal model [50,51].…”

Section: Capparis Sppmentioning

confidence: 87%

Potentially effective natural drugs in treatment for the most common rheumatic disorder: osteoarthritis

Farzaei

Gooshe

et al. 2014

Rheumatol Int

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Osteoarthritis (OA) is a chronic condition in which imbalance between anabolic and catabolic mediators occurs leading to the destruction of homeostasis of articular cartilage. The current drugs in the management of OA can just alleviate symptoms. Hence, the research tendency toward exploration of novel sources has been grown up in order to achieve safe and efficacious drugs. Meanwhile, various components exist as novel natural drugs that may possess favorable properties for the management of OA. This review focuses on the most efficacious medicinal plants and their phytochemical agents, which have been consumed for the management of OA. Moreover, evaluation of their efficacy and molecular mechanisms of action are discussed based on numerous modern experimental investigations. More research is needed to develop therapeutic agents with disease-modifying properties to treat OA.

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“…The present results suggests that the pain reliever effect of caper could be due to the anti-inflammatory and protective effects of spermidine alkaloids as well as to the presence of other phyto-chemicals able to reduce the firing of sensitive neurons. Accordingly, Arslan et al (2010) showed that the bud extract of Capparis ovata, exerted anti-nociceptive action through both peripheral and central mechanisms. Finally, applying different chromatographic methods and after a depth investigation by mass spectrometry, the presence of other potential active compounds such as quercetin or other flavonoids, which could exert anti-oxidative activity, was excluded.…”

Section: Discussionmentioning

confidence: 99%

“…Several authors (Al-Said et al, 1988;Sher and Alyemeni, 2010) reported that, in traditional medicine, infusions made from caper are considered to be beneficial for the treatment of rheumatism, gout and abdominal pains; moreover, pastes are used for topic applications to treat swollen joints, skin rashes and burns (Eddouks et al, 2004;Inocencio et al, 2002). The anti-nociceptive and anti-inflammatory properties of Capparis are described in different animal models (Arslan et al, 2010;Zhou et al, 2010). In particular, flowering buds and fruits of Capparis spinosa have shown significant anti-inflammatory and anti-oxidant effects in both in vivo and in vitro model of articular damage (Feng et al, 2011;Panico et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Acute effect of Capparis spinosa root extracts on rat articular pain

Maresca

Micheli

Mannelli

et al. 2016

Journal of Ethnopharmacology

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a b s t r a c tEthnopharmacological relevance: Capparis spinosa L. originates from dry regions of Asia and Mediterranean basin. In traditional medicine of these areas, infusions from caper root are considered to be beneficial for the treatment of rheumatism, gout and against abdominal pains. Aim of the study: To evaluate the pain relieving properties of a Syrian cultivar of Capparis spinosa roots in rat models of osteoarthritis and rheumatoid arthritis. Materials and methods: Decoction (DEC) and hydroalcoholic extract (EtH 2 O) were obtained from powdered roots; the latter was further separated in CH 2 Cl 2 and aqueous (H 2 O-Res) fractions. The extracts were characterized in terms of spermidine alkaloids by HPLC/DAD/MS and stachydrine by NMR. Different amount of free and glycosilated forms of capparispine and analogues (from 0.5% w/w for DEC up to 7.6% w/w for CH 2 Cl 2 fraction) were detected. Rat models of rheumatoid arthritis and osteoarthritis were induced by the intra-articular administration of Complete Freund's Adjuvant (CFA) or monosodium iodoacetate (MIA), respectively. Results: Fourteenth days after CFA or MIA injection, the different preparations of Capparis spinosa (3, 30, 100 and 300 mg kg À 1 ) were acutely administered p.o.. Powdered roots (300 mg kg ) significantly reduced hypersensitivity to mechanical noxious stimuli as well as spontaneous pain evaluated as hind limb bearing alterations in both models. The CH 2 Cl 2 and the H 2 O-Res (30 mg kg À 1 ) were the most potent in reverting pain threshold alterations despite the different content of free alkaloids. Conclusions: Capparis spinosa extracts relieved pain related to rheumatoid arthritis and osteoarthritis after single administration. A synergistic effect due to a specific "phytochemical mixture" is suggested.

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Antinociceptive activity of methanol extract of fruits of Capparis ovata in mice

Cited by 63 publications

References 21 publications

Antioxidant, analgesic, and anti-inflammatory activities of the ethanolic extracts of Taxillus liquidambaricola

Antioxidant, analgesic, and anti-inflammatory activities of the ethanolic extracts of Taxillus liquidambaricola

Potentially effective natural drugs in treatment for the most common rheumatic disorder: osteoarthritis

Acute effect of Capparis spinosa root extracts on rat articular pain

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