Antinociceptive activity of Maytenus rigida stem bark

Dias, Kellyane S.; Marques, Maxsuel S.; Menezes, Igor Alexandre Côrtes de; Santos, Thiago C.; Silva, Aline B. L.; Estevam, Charles S.; Santana, Antônio Euzébio Goulart; Pìzza, Cosimo; Antoniolli, Ângelo Roberto; Marçal, R. M.

doi:10.1016/j.fitote.2007.02.017

Cited by 15 publications

(17 citation statements)

References 8 publications

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“…These findings appear to be consistent with the proven medicinal properties of this plant Dias et al, 2007), which can be used without causing any problems of cell division.…”

Section: Genotoxicity Test Of Maytenus Rigida and Aristolochia Birostsupporting

confidence: 87%

“…When the newly emerged roots were 1-2 cm in length, they were used in the test. Roots of A. cepa were treated with a series of concentrations of the plant extracts during 24 h. Three concentrations of each extract were used here, representing low (100 mg/L), intermediate (200 mg/L) and high (400 mg/L) levels of the extract, following standard procedures in pharmacological trials (Dias et al, 2007). The substances were diluted with distilled water and the control group was treated also with distilled water.…”

Section: Evaluation Of Genotoxicity In the Meristemic Tissue Of Alliumentioning

confidence: 99%

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Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa

Mendes¹,

Andrade²,

Xavier³

et al. 2012

Rev. bras. farmacogn.

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Abstract:Medicinal plants are an important source of treatment for many ailments, although little is known of the potential genotoxic effects of most species. In the present study, two species from diverse and medicinally important genera -Maytenus rigida Mart., Celastraceae, and Aristolochia birostris Ducht, Aristolochiaceae -were analyzed to identify potentially significant secondary metabolites and the possible effects of their aqueous and alcoholic extracts on cell division in the onion root stem (genotoxicity test). The phytochemical testing revealed the presence of a number of potentially important secondary compounds in both species, including phenols, flavonoids, triterpenoids, steroids, and saponins. In the genotoxicity tests, no chromosomal abnormalities of any kind were observed in either species. In the case of M. rigida, a significant increase in mitotic activity was observed at the highest concentration. No significant tendency was recorded in A. birostris, although a considerable increase in the prophase was observed at all concentrations of the alcoholic extract. The triterpenoid content of both species may be especially important from a medicinal viewpoint, although recent findings on the carcinogenic potential of Aristolochia extracts demands caution in the interpretation of the results, and the need for further research.

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“…These findings appear to be consistent with the proven medicinal properties of this plant Dias et al, 2007), which can be used without causing any problems of cell division.…”

Section: Genotoxicity Test Of Maytenus Rigida and Aristolochia Birostsupporting

confidence: 87%

Section: Evaluation Of Genotoxicity In the Meristemic Tissue Of Alliumentioning

confidence: 99%

Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa

Mendes¹,

Andrade²,

Xavier³

et al. 2012

Rev. bras. farmacogn.

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“…2 Popularmente é conhecida como "espinheira-santa" e utilizada no tratamento de lesões gástricas (antiulcerogênica), antiinflamatória, analgésica, cicatrizante em feridas, antiasmática, como remédio antitumoral indígena e como agente regulador da fertilidade, hábito comum de algumas tribos indígenas e populações rurais do Paraguai e Bolívia. 2,3 Diversas atividades, como antiulcerogênica, 3,4 antiinflamatória, 3,4 antiedematogênica, 4 antinociceptiva, [3][4][5] antiproliferativa, 6 de diferentes extratos, de frações ricas em flavonóides e de substâncias isoladas de M. ilicifolia, M. rigida, M. robusta e M. truncata foram avaliadas e comprovadas. Além dessas atividades, o extrato de M. ilicifolia foi avaliado para proteção da cóclea em animal de laboratório, devido à cisplatina, demonstrando que o mesmo não possui qualquer efeito protetivo.…”

Section: Introductionunclassified

“…Além dessas atividades, o extrato de M. ilicifolia foi avaliado para proteção da cóclea em animal de laboratório, devido à cisplatina, demonstrando que o mesmo não possui qualquer efeito protetivo. 7 Os constituintes químicos presentes nas diferentes espécies avaliadas estão relacionados aos grupos de taninos condensados (4´-metil-epigalocatequina), 5 flavonóides 8 e triterpenos (pristimerina). 3,6 Em outras espécies, M. acanthophylla e M. aquifolium, foram isolados constituintes químicos semelhantes aos já encontrados em M. ilicifolia.…”

Section: Introductionunclassified

Atividade antioxidante de extratos e taninos condensados das folhas de Maytenus ilicifolia Mart. ex Reiss.

Pessuto¹,

Costa²,

Souza³

et al. 2009

Quím. Nova

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Recebido em 8/7/08; aceito em 29/9/08; publicado na web em 26/1/09 ANTIOXIDANT ACTIVITY OF EXTRACTS AND CONDENSED TANNINS FROM LEAVES OF Maytenus ilicifolia MART. ex REISS. Maytenus ilicifolia (Celastraceae) is a native plant of South America and popularly known as "espinheira-santa". The aim of this study was to evaluate the antioxidant capacity of extracts and isolated compounds from this plant. The antioxidant activity of the crude and semipurified extracts and isolated compounds was evaluated through DPPH-radical and phosphomolybdenum-complex assays. By both methods, the ethyl-acetate fraction demonstrated better antioxidant capacity compared with vitamin C and trolox. In the compounds, the higher the number of hydroxyls, the greater the antioxidant activity. In addition, stereochemistry influenced antioxidant activity, i.e., compounds with 2R,3R showed greater activity than those with 2R,3S.Keywords: Maytenus ilicifolia; condensed tannins; antioxidant activity. introdUÇÃoMaytenus ilicifolia Mart. ex Reiss. (Celastraceae) é uma planta nativa do sul do Brasil, Uruguai, Paraguai, norte da Argentina, 1 Chile e Bolívia. 2 Popularmente é conhecida como "espinheira-santa" e utilizada no tratamento de lesões gástricas (antiulcerogênica), antiinflamatória, analgésica, cicatrizante em feridas, antiasmática, como remédio antitumoral indígena e como agente regulador da fertilidade, hábito comum de algumas tribos indígenas e populações rurais do Paraguai e Bolívia. 2,3 Diversas atividades, como antiulcerogênica, 3,4 antiinflamatória, 3,4 antiedematogênica, 4 antinociceptiva, 3-5 antiproliferativa, 6 de diferentes extratos, de frações ricas em flavonóides e de substâncias isoladas de M. ilicifolia, M. rigida, M. robusta e M. truncata foram avaliadas e comprovadas. Além dessas atividades, o extrato de M. ilicifolia foi avaliado para proteção da cóclea em animal de laboratório, devido à cisplatina, demonstrando que o mesmo não possui qualquer efeito protetivo. 7 Os constituintes químicos presentes nas diferentes espécies avaliadas estão relacionados aos grupos de taninos condensados (4´-metil-epigalocatequina), 5 flavonóides 8 e triterpenos (pristimerina). 3,6 Em outras espécies, M. acanthophylla e M. aquifolium, foram isolados constituintes químicos semelhantes aos já encontrados em M. ilicifolia. 9 Taninos condensados são apontados como constituintes químicos majoritários em extratos aquosos de M. ilicifolia, sendo utilizados como marcadores no controle de qualidade de extratos e medicamentos fitoterápicos através de diferentes técnicas de avaliação e desenvolvimento tecnológico. 10 Testes de toxicidade aguda e crônica realizados com o infuso das folhas de M. ilicifolia não provocaram efeitos tóxicos (estudo pré-clínico), 11 mutagênicos 12 e teratogênicos 13 em animais ou em células vegetais. Alguns autores 14 realizaram ensaio clínico fase I com abafado (infuso) das folhas de espinheira-santa e demonstraram que o abafado não é tóxico ao ser humano. Substâncias fenólicas são reconhecidamente detentoras de pronunciada ati...

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“…The book As Muitas Faces da Jurema (The Many Faces of Jurema) describes the use of the bark of M. rigida as a component of "jurema-preta" tea, known for its hallucinogenic properties (Mota & Albuquerque, 2002) and a previous study showed its antimicrobial activity (Estevam et al, 2009). Since M. rigida reportedly have analgesic activities (Mota & Albuquerque, 2002;Dias et al, 2007), the aim of the present study was better to investigate the antinociceptive (central and peripheral) properties of the ethanol extract of the plant, ethyl acetate fraction, and an isolated compound, using three in vivo mice models, namely, the acetic acid-induced writhing test, the hot plate test, and the formalin-induced nociception test.…”

Section: Introductionmentioning

confidence: 99%

Antinociceptive effects of an extract, fraction and an isolated compound of the stem bark of Maytenus rigida

Martins¹,

Estevam²,

Santos³

et al. 2012

Rev. bras. farmacogn.

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Abstract:The antinociceptive activity of the Maytenus rigida Mart. (Celastraceae) ethanol extract and its ethyl acetate fraction as well as of (-)-4′-methylepigallocatechin (1), a previously isolated compound, was demonstrated in vivo. ED50 for 1 in the writhing test was 14.14 mg/kg. The acetic acid-induced writhing was inhibited by 98.4, 84.4, and 58.3%, respectively, when mice were treated with the ethanol extract, ethyl acetate fraction, and 1. In the hot plate test, mice pretreated with 1 showed signifi cantly increased reaction times (60-89%). Oral administration of 1 signifi cantly inhibited fi rst and second phases of the formalin-induced pain (50 and 26.5%, respectively), whereas indomethacin inhibited only the second phase of the test (41.2%). Ethanol extract and its fraction showed effects on infl ammatory pain, while neurogenic and infl ammatory pain suppression by 1 is a strong indication of the presence of both central and peripheral effects and suggests its analgesic and anti-infl ammatory potential.

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Antinociceptive activity of Maytenus rigida stem bark

Cited by 15 publications

References 8 publications

Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa

Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa

Atividade antioxidante de extratos e taninos condensados das folhas de Maytenus ilicifolia Mart. ex Reiss.

Antinociceptive effects of an extract, fraction and an isolated compound of the stem bark of Maytenus rigida

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