Antinociceptive activity of<i>Syzygium cumini</i>leaves ethanol extract on orofacial nociception protocols in rodents

Quintans, Jullyana S.S.; Brito, Renan Guedes de; Aquino, Pedro Gregório Vieira; França, Paulo Henrique Barcellos; Siqueira-Lima, Pollyana S.; Santana, Antônio Euzébio Goulart; Ribeiro, Êurica Adélia Nogueira; Salvador, Marcos José; Araújo-Júnior, João Xavier de; Quintans‐Júnior, Lucindo J.

doi:10.3109/13880209.2013.870582

Cited by 16 publications

(15 citation statements)

References 20 publications

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“…cumini, commonly known as jambolan, is a large evergreen and foliaceous tree whose seeds, bark, fruit and leaves have been used in traditional medicine. It is reported to have antioxidant, antinociceptive, hypoglycemic, anti-Leishmania and antimicrobial properties (Eshwarappa et al 2014;Quintans et al 2014;Rodrigues et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Antifungal potential ofSideroxylon obtusifoliumandSyzygium cuminiand their mode of action againstCandida albicans

Pereira

Freires

Castilho

et al. 2016

Pharmaceutical Biology

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Context The emergence of resistant pathogens and toxicity of antifungals have encouraged an active search for novel candidates to manage Candida biofilms. Objective In this study, the little known species Sideroxylon obtusifolium T.D. Penn (Sapotacea) and Syzygium cumini (L.) Skeels (Myrtaceae), from the Caatinga biome in Brazil were chemically characterized and explored for their antifungal potential against C. albicans. Materials and methods We determined the effects of hydroalcoholic extracts/fractions upon fungal growth (minimum inhibitory and fungicidal concentrations, MIC/MFC), biofilm morphology (scanning electron microscopy) and viability (confocal laser scanning microscopy), proposed their mode of action (sorbitol and ergosterol assays), and finally investigated their effects against macrophage and keratinocyte cells in a cell-based assay. Data were analysed using one-way analysis of variance with Tukey-Kramer post-test (a ¼ 0.05). Results The n-butanol (Nb) fraction from S. obtusifolium and S. cumini extract (Sc) showed flavonoids (39.11 6 6.62 mg/g) and saponins (820.35 6 225.38 mg/g), respectively, in their chemical composition and demonstrated antifungal activity, with MICs of 62.5 and 125 lg/mL, respectively. Nb and Sc may complex with ergosterol as there was a 4-16-fold increase in MICs in the presence of exogenous ergosterol, leading to disrupted permeability of cell membrane. Deleterious effects were observed on morphology and viability of treated biofilms from concentrations as low as their MICs and higher. Sc was not toxic to macrophages and keratinocytes at these concentrations (p > 0.05), unlike Nb. Conclusions Nb and Sc demonstrated considerable antifungal activity and should be further investigated as potential alternative candidates to treat Candida biofilms. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Antifungal potential ofSideroxylon obtusifoliumandSyzygium cuminiand their mode of action againstCandida albicans

Pereira

Freires

Castilho

et al. 2016

Pharmaceutical Biology

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“…The fingerprinting using electrospray ionization mass spectrometry analyses (ESI-MS) were performed according to Salvador [8,11]. The solutions were injected by direct infusion in the mass spectrometer using UPLC-MS equipment, model ACQUITY TQD (Waters Corporation, Milford, MA).…”

Section: Electrospray Ionization Mass Spectrometry Fingerprintingmentioning

confidence: 99%

“…The collision gás pressure was optimized to produce extensive fragmentation of the ion under investigation. The compounds were identified by comparing their ESI-MS/MS fragmentation spectra to fragmentation spectra of authentic standard samples and literature data [8,11,12].…”

Section: Electrospray Ionization Mass Spectrometry Fingerprintingmentioning

confidence: 99%

“…The EHSCF extract was analysed by direct insertion in the negative ion mode and this method is a sensitive and selective for the identification of polar organic compounds with acidic sites, such as the organic acids [8,11,13].…”

Section: Electrospray Ionization Mass Spectrometry Fingerprintingmentioning

confidence: 99%

“…The fruits have been used as medicines in the traditional treatment of diabetes, pharyngitis, spleenopathy, urethrorrhea and ringworm infection. Scientific reports have shown that the extracts of S. cumini possess cardioprotective, antioxidant, hypoglycemic, antidiabetic and antinociceptive effects [7,8].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of cardiovascular effects of edible fruits of <i>Syzygium cumini</i> Myrtaceae (L) skeels in rats

Herculano¹,

Costa²,

Rodriques³

et al. 2014

Trop. J. Pharm Res

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Purpose: To evaluate the hypotensive, vasorelaxant and antihypertensive effects elicited by the hydroalcohol extract from the fruits of Syzygium cumini (EHSCF) in non-anesthetized rats. Methods:The rats were anesthetized and polyethylene catheters were inserted into the lower abdominal aorta and into the inferior vena cava for blood pressure measurements and administration of drugs. After a recovery period of 24 h, EHSCF (0.5;1;5;10; 20 and 30 mg/kg, i.v.) EHSCF (0.5;1;5;10; 20 and 30 mg/kg) induced hypotension (-15 ± 1, -14 ± 1, -15 ± 1, -13 ± 1, -11 ± 1 and -13 ± 2 %) and bradycardia (-6 ± 1, -5 ± 1, -6 ± 1, -14 ± 1, -8 ± 1 and -10 ± 2 %) in normotensive rats. These responses were attenuated by pre-treatment with L-NAME, indomethacin, hexamethonium or atropine. In phenylephrine, pre-contracted mesenteric rings, EHSCF-induced relaxation (Emax = 54.6 ± 4.5 % and pD2 = 2.7 ± 0.1)

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Traditional uses, pharmacological activities, and phytochemical constituents of the genus Syzygium: A review

Uddin

Hossain

Reza

et al. 2022

Food Science & Nutrition

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This comprises medicinal plants not only important for the treatment of diseases but also as potential material for maintaining good health and conditions. Better cultural acceptability, better compatibility and adaptability with the human body, and lesser side effects of plants made many countries in the world to depend on herbal medicine for their primary health care (Bari et al., 2021;CHOWDHURY et al., 2021;Hoque et al., 2021). For centuries, plants are being widely used for their natural resources isolated from various parts of a plant and have been used in the treatment of human diseases. Moreover, some of these plants produce edible fruits, while others simply produce dazzling flowers, which are so attractive and important economically as well.The knowledge of traditional medicine supports all other systems of medicine such as Ayurveda, Siddha, Unani, and even modern

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Antinociceptive activity ofSyzygium cuminileaves ethanol extract on orofacial nociception protocols in rodents

Abstract: We can suggest that the antinociceptive effect of the EE is mediated by peripheral mechanisms, possibly involving KATP channels and the nitric oxide pathways. These effects appear to be related to the presence of flavonoids compounds, such as quercetin.

Cited by 16 publications

References 20 publications

Antifungal potential ofSideroxylon obtusifoliumandSyzygium cuminiand their mode of action againstCandida albicans

Antifungal potential ofSideroxylon obtusifoliumandSyzygium cuminiand their mode of action againstCandida albicans

Evaluation of cardiovascular effects of edible fruits of <i>Syzygium cumini</i> Myrtaceae (L) skeels in rats

Traditional uses, pharmacological activities, and phytochemical constituents of the genus Syzygium: A review

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