Antinociceptive activity of carvacrol (5-isopropyl-2-methylphenol) in mice

Melo, Francisca Helvira Cavalcante; Rios, Emiliano Ricardo Vasconcelos; Rocha, Nayrton Flávio Moura; Citó, Maria do Carmo de Oliveira; Fernandes, Mariana Lima; Sousa, Damião Pergentino de; Vasconcelos, Silvânia Maria Mendes; Sousa, Francisca Cléa Florenço de

doi:10.1111/j.2042-7158.2012.01552.x

Cited by 57 publications

(27 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pain is one of the most distressing symptoms in over half of all cancer patients (Schmidt, Hamamoto, Simone, & Wilcox, ). Carvacrol possesses analgesic and anti‐inflammatory effects and is shown to be a modulator of central neurotransmitter pathways, such as dopaminergic, serotoninergic, and GABAergic systems, as well as releasing inflammatory mediators (Cavalcante Melo et al, ).…”

Section: Resultsmentioning

confidence: 99%

Carvacrol and human health: A comprehensive review

Sharifi‐Rad

Varoni

Iriti

et al. 2018

Phytotherapy Research

362

227

View full text Add to dashboard Cite

Carvacrol (CV) is a phenolic monoterpenoid found in essential oils of oregano (Origanum vulgare), thyme (Thymus vulgaris), pepperwort (Lepidium flavum), wild bergamot (Citrus aurantium bergamia), and other plants. Carvacrol possesses a wide range of bioactivities putatively useful for clinical applications such antimicrobial, antioxidant, and anticancer activities. Carvacrol antimicrobial activity is higher than that of other volatile compounds present in essential oils due to the presence of the free hydroxyl group, hydrophobicity, and the phenol moiety. The present review illustrates the state-of-the-art studies on the antimicrobial, antioxidant, and anticancer properties of CV. It is particularly effective against food-borne pathogens, including Escherichia coli, Salmonella, and Bacillus cereus. Carvacrol has high antioxidant activity and has been successfully used, mainly associated with thymol, as dietary phytoadditive to improve animal antioxidant status. The anticancer properties of CV have been reported in preclinical models of breast, liver, and lung carcinomas, acting on proapoptotic processes. Besides the interesting properties of CV and the toxicological profile becoming definite, to date, human trials on CV are still lacking, and this largely impedes any conclusions of clinical relevance.

show abstract

Section: Resultsmentioning

confidence: 99%

Carvacrol and human health: A comprehensive review

Sharifi‐Rad

Varoni

Iriti

et al. 2018

Phytotherapy Research

362

227

View full text Add to dashboard Cite

show abstract

“…Linalool has antinociceptive properties in chronic inflammatory and neuropathic hypersensitivity (Batista et al, 2010). Carvacrol produces antinociceptive activity in mice (Cavalcante et al, 2012). Limonene is a monoterpene in essential oils of various plants such as Lippia alba (Do Vale et al, 2002), Artemisia dracunculus L (Sayyah et al, 2004) and other aromatic plants species (Saeidnia et al, 2004), including mushrooms (Breheret et al, 1997;Rapior et al, 1997).…”

Section: Introductionmentioning

confidence: 98%

Involvement of transient receptor potential A1 channel in algesic and analgesic actions of the organic compound limonene

Kaimoto

Hatakeyama

Takahashi

et al. 2016

European Journal of Pain

View full text Add to dashboard Cite

Topically applied limonene stimulates TRPA1, resulting in elicitation of acute pain, but its systemic application inhibits nociception induced by oxidative stress. Because limonene is a safe compound, it may be utilized for pain control due to its inhibition of TRPA1 channels. What does this study add: Limonene, a monoterpene in essential oils of various plants, has been known for its antitumor and anti-inflammatory properties. However, molecular basis of their actions has not been identified. This study shows that limonene activates nociceptive TRPA1 and elicits acute pain, when it is topically applied. In addition, systemic application of limonene exerts inhibitory effects on nociception induced by an oxidative stress-induced TRPA1 activation.

show abstract

“…Eugenol has been used in dentistry as a local anesthetic (Markowitz et al, 1992) owing to its inhibitory effect on voltage-gated sodium and calcium channels in trigeminal nociceptors (Lee et al, 2005; Park et al, 2006; Chung et al, 2008; Park et al, 2009). Carvacrol has also been reported to have antinociceptive effects (Cavalcante Melo et al, 2012). Additionally, eugenol and carvacrol elicit oral pungency (Cliff Heymann, 1992; Klein et al, 2013) and eugenol activates TRPA1 and TRPV1 (Bandell et al, 2004) that are expressed in nociceptive nerve endings.…”

Section: Introductionmentioning

confidence: 99%

Eugenol and carvacrol excite first- and second-order trigeminal neurons and enhance their heat-evoked responses

et al. 2014

View full text Add to dashboard Cite

Eugenol and carvacrol from clove and oregano, respectively, are agonists of the warmth-sensitive transient receptor potential channel TRPV3 and the irritant-sensitive TRPA1. Eugenol and carvacrol induce oral irritation that rapidly desensitizes, accompanied by brief enhancement of innocuous warmth and heat pain in humans. We presently investigated if eugenol and carvacrol activate nociceptive primary afferent and higher-order trigeminal neurons and enhance their heat-evoked responses, using calcium imaging of cultured trigeminal ganglion (TG) and dorsal root ganglion (DRG) neurons, and in vivo single-unit recordings in trigeminal subnucleus caudalis (Vc) of rats. Eugenol and carvacrol activated 20-30% of TG and 7-20% of DRG cells, the majority of which additionally responded to menthol, mustard oil and/or capsaicin. TG cell responses to innocuous (39°) and noxious (42°C) heating were enhanced by eugenol and carvacrol. We identified dorsomedial Vc neurons responsive to noxious heating of the tongue in pentobarbital-anesthetized rats. Eugenol and carvacrol dose-dependently elicited desensitizing responses in 55% and 73% of heat-sensitive units, respectively. Responses to noxious heat were briefly enhanced by eugenol and carvacrol. Many eugenol- and carvacrol-responsive units also responded to menthol, cinnamaldehyde and capsaicin. These data support a peripheral site for eugenol and carvacrol to enhance warmth- and noxious heat-evoked responses of trigeminal neurons, and are consistent with the observation that these agonists briefly enhance warmth and heat pain on the human tongue.

show abstract

Antinociceptive activity of carvacrol (5-isopropyl-2-methylphenol) in mice

Abstract: Based on these results, it has been suggested that carvacrol presents antinociceptive activity that may not act through the opioid system nor through inhibition of the nitric oxide pathway.

Cited by 57 publications

References 38 publications

Carvacrol and human health: A comprehensive review

Carvacrol and human health: A comprehensive review

Involvement of transient receptor potential A1 channel in algesic and analgesic actions of the organic compound limonene

Eugenol and carvacrol excite first- and second-order trigeminal neurons and enhance their heat-evoked responses

Contact Info

Product

Resources

About