Antinociceptive activity of Astragalus gummifer gum (gum tragacanth) through the adrenergic system: A in vivo study in mice

Bagheri, Seyyed Majid; Keyhani, Leila; Heydari, Mehrangiz; Dashti-R, Mohammad Hossein

doi:10.4103/0975-9476.146543

Cited by 23 publications

(5 citation statements)

References 21 publications

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“…The doses of ketoprofen, opioid, muscarinic, nicotinic, and adrenergic receptor agonists and antagonists were determined by previous studies, which identified the maximum dose that did not affect motor function [24,25,26,27,28,29]. …”

Section: Methodsmentioning

confidence: 99%

Antinociceptive Effects of Ginsenoside Rg3 in a Rat Model of Incisional Pain

Ahn

Choi²,

Kang³

et al. 2016

Eur Surg Res

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Background: Ginsenoside Rg3 is an extract of total ginseng saponins, which accounts for 4.7% of all saponins. This study aimed to identify the mechanisms of the antinociceptive effects of ginsenoside Rg3. Methods: Rats were randomly divided into six groups, which were treated with vehicle or 0.5, 1, 1.5, 2, or 4 mg/kg of ginsenoside Rg3 intraperitoneally 2 h after a plantar incision was made. To evaluate the mechanisms of antinociceptive effects, the rats were intraperitoneally injected with naloxone 5 mg/kg, atropine 1 mg/kg, yohimbine 2 mg/kg, mecamylamine 1 mg/kg, prazosin 1 mg/kg, and dexmedetomidine 5 μg/kg. Hyperalgesia produced by the plantar incision was assessed using von Frey filaments 1 day before the incision (BI) and 2 h after the plantar incision (AP); this measurement was repeated at 15, 30, 45, 60, 80, 100 and 120 min, and 24 and 48 h after the injection of ginsenoside Rg3. Serum interleukin-1β (IL-1β) and interleukin-6 (IL-6) levels were measured 1 day before incision and 120 min, 24 h, and 48 h after the injection of ginsenoside Rg3 or vehicle. Results: The mechanical withdrawal threshold (MWT) significantly increased in the group that received ginsenoside Rg3. The dose-MWT response showed a curvilinear, bell-shaped relationship. The maximum MWT was found with the administration of ginsenoside Rg3 at 1.5 mg/kg; MWT decreased to 2 and 4 mg/kg. Yohimbine diminished the analgesic effect of ginsenoside Rg3. Prazosin and dexmedetomidine increased the analgesic effect of ginsenoside Rg3. IL-1β and IL-6 appeared significantly lower relative to control group. Conclusions: Ginsenoside Rg3 has an analgesic effect with a curvilinear dose-response relationship. Alpha 2 adrenergic receptor appeared to be related to the analgesic effect of ginsenoside Rg3. Also, the anti-inflammatory effect of ginsenoside Rg3 could be related to its analgesic effect.

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Section: Methodsmentioning

confidence: 99%

Antinociceptive Effects of Ginsenoside Rg3 in a Rat Model of Incisional Pain

Ahn

Choi²,

Kang³

et al. 2016

Eur Surg Res

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“…It has also shown that the presence of phenolic and flavonoid compounds were associated with antiinflammatory and antinociceptive activity of other species of asparagus. The hydroalcoholic extract of A. radix (Maresca et al, 2017), A. pubescens (Nwafor and Okwuasaba, 2003) and A. hamosus (Shojaii et al, 2015), as well as the gum of A. gummifer (Bagheri et al, 2015) exerted a significant antinociceptive activity.…”

Section: Asparagus Officinalis L (Asparagus) Frommentioning

confidence: 99%

Antioxidant and antinociceptive effects of hydroalcoholic root extract of Asparagus officinalis L.

et al. 2020

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Introduction: Asparagus officinalis L. is a medicinal plant, which contains various natural bioactive phytochemicals with potential different pharmacological activities. The present study was designed to investigate the antioxidant and antinociceptive activities of the hydroalcoholic extract obtained from asparagus roots. Methods: The plant material was extracted using ethanol 70% and preliminary phytochemical analyses were carried out. The in vitro antioxidant effects of the plant extract were evaluated using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radicals and total reducing ability compared to the butylated hydroxytoluene (BHT) as a standard control. The antinociceptive effects were also assessed using formalin and tail-flick test in male Wistar rats. Results: The plant extract was relatively rich in flavonoids. The IC50 value for DPPH scavenging activity of the extract (1117.65±14.26 μg/ml) was significantly higher than that of BHT (64.35±4.09 μg/ml). The plant extract exerted a significantly lower total reducing ability compared to that of BHT. The extract exhibited a significant antinociceptive effect at the early stage of formalin test in the dose of 500mg/kg intraperitoneally. The results of tail-flick test also demonstrated antinociceptive effects compared to control in a dose-dependent manner. However, these antinociceptive activities were not comparable with morphine as a reference agent. Conclusion: A. officinalis roots extract demonstrated considerable antioxidant and antinociceptive activities and it might be attributed to its flavonoids content.

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“…In comparison with other groups, there were differences but not significant between the group treated with apigenin (27.2±4.11) and diclofenac (23.8±3.36), which recorded the lowest number of writhing values (Table 2). To evluate the central and peripheral influnces of analgesics in mice, the writing test employs a chemical technique involving intraperitoneal administration of acetic acid to induce pain (Bagheri et al, 2015;Fattollah et al, 2023). The analgesic activity indicated a reduction in frequency.…”

Section: Acetic Acid Testmentioning

confidence: 99%

Comparative Analgesic Effect of Portulaca oleracea L. Extracted Apigenin and Diclofenac in Mice

Fahd,

Saliem

2024

AAVS

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This article aims to determine the analgesic impact of Apigenin and Diclofenac in mice model. In the beginning, 84 male albino mice were selected, acclimated, and categorized into four equal groups: The 1st tested by the hot plate, the 2nd treated with acetic acid, the 3rd examined by application 10 μl of 2% formalin solution and the 4th was examined by the tail-flick test. Within each experiment, the study mice were subdivided equally into three subgroups; the 1st was administered only distilled water (control), the 2nd was drenched with apigenin (50 mg/Kg B.W.) orally, and the 3rd was drenched only diclofenac (0.71 mg/kg B.W). The hot plate's outcomes showed that the animals treated with apigenin significantly increased in time than with diclofenac. The number of writhes in both apigenin and diclofenac-treated groups has been significantly reduced in the acetic acid test when compared to the control. The formalin test revealed that both apigenin and diclofenac-treated groups reported significantly lower flinches and licks than the control. For the tail-flick test, the results have significantly increased in withdrawal time in apigenin and diclofenac-treated groups than with the control; with the ability of apigenin to relieve the pain when compared with diclofenac.

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Antinociceptive activity of Astragalus gummifer gum (gum tragacanth) through the adrenergic system: A in vivo study in mice

Cited by 23 publications

References 21 publications

Antinociceptive Effects of Ginsenoside Rg3 in a Rat Model of Incisional Pain

Antinociceptive Effects of Ginsenoside Rg3 in a Rat Model of Incisional Pain

Antioxidant and antinociceptive effects of hydroalcoholic root extract of Asparagus officinalis L.

Comparative Analgesic Effect of Portulaca oleracea L. Extracted Apigenin and Diclofenac in Mice

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