Antinociceptive action of aqueous extract of the leaves ofIxora coccinea

Ratnasooriya, W.D.; Deraniyagala, S.A.; Bathige, S.D.N.K.; Goonasekara, Charitha L.; Jayakody, J. R. A. C.

doi:10.1556/abiol.56.2005.1-2.3

Cited by 24 publications

(8 citation statements)

References 18 publications

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“…The observed anti-nociceptive effects of COE can also be traced to its antioxidant activity secondary to its phytoconstituents. For example, Ratnasooriya et al (2005) had suggested a link between antioxidant activity and anti-nociception. In this study our results have demonstrated significant antioxidant activity of COE (Table 2) which invariably can be attributable to its saponins, flavonoids, and anthraquinones components (Table 1) as has been shown by previous works (Ferreira et al, 2004;Masoko et al, 2010;Sur et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Anti-nociceptive and antioxidant activities of an aqueous leaf extract of Corchorus olitorius L. (Tiliaceae)

Boye¹,

Barku²,

Amoateng³

et al. 2015

Int. J. Bio. Chem. Sci

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A preliminary study had shown that C. olitorius has analgesic activity possibly mediated through opioidergic pathway. The study was a follow up work to evaluate the anti-nociceptive effects and other possible mechanisms of action of an aqueous leaf extract of C. olitorius (COE) using formalin-induced nociception test. COE was screened for its analgesic, and antioxidant activities. The anti-nociceptive effect of COE (3x10-2 , 1x10-1 and 3x10-1 g kg-1 , p.o), and morphine (1x10-3 , 3x10-3 and 1x10-2 gkg-1 , i.p.) were evaluated using the formalin-induced nociception test. The study showed that C. olitorius has analgesic activity possibly mediated through opioidergic pathway. COE produced significant (P ˂ 0.05) dose-dependent antinociceptive effects similar to morphine in both phases of formalin-induced nociception. The extract showed free radical scavenging properties and different phyto-constituents such as alkaloids, flavonoids, saponins, cardiac glycosides, tannins, anthraquinones and terpenoids were identified. COE has both central and peripheral anti-nociceptive effects mediated through opioidergic receptor activation and also partly through ATP-sensitive K + channel activation systems. The findings confirms earlier reports, and further shows that C. olitorius produces anti-nociception by interrupting many pain processing pathways. Results further suggest that the extract (COE) might possess some chemical constituents that are responsible for the analgesic and the antioxidant activities.

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Section: Discussionmentioning

confidence: 99%

Anti-nociceptive and antioxidant activities of an aqueous leaf extract of Corchorus olitorius L. (Tiliaceae)

Boye¹,

Barku²,

Amoateng³

et al. 2015

Int. J. Bio. Chem. Sci

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“…One of four doses (500, 750, 1000 or 1500 mg/kg, n=8/dose) of aqueous leaf extract (ALE) or 1 ml of distilled water was orally administered to male rats. The results showed that ALE possesses considerable antinociceptive activity, when evaluated in hot plate and formalin test but not in tail flick test 33 .…”

Section: Antinociceptive Activitymentioning

confidence: 91%

Untitled

2015

IJPSR

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Medicinal herbs used in modern medicine are occupying a very significant place as raw materials for important drugs. India officially recognizes over 3000 plants for their medicinal value. It is generally estimated that over 6000 plants in India are used in traditional, folk and herbal medicine. Traditionally Ixora is found to be useful for many ailments like hepatic disorder, cancer, microbial infection, antioxidant, pain, inflammation, etc. and has been documented for various medicinal properties. The genus Ixora has been reported to possess different classes of compounds mainly triterpenoids (lupeol, urosilic acid, oleanolic acid betunolic acid, amyrins, etc.), aromatic acrid oils, tannins, saponins, carbohydrate, fatty acids, flavanoids (rutin, formononetin, β-sitosterol, quercetin and kaempferol) and sterols. Out of many species of Ixora much research was done on I. coccinea and some part of the work on I. chinensis, I. javanica, I. finlaysoniana, I. parviflora and I. macrothyrsa. The main aim is to provide a comprehensive review on the phytochemical and pharmacological aspects of various species of Ixora. In the present review, efforts are made in addressing its ethnomedicinal uses, chemical constituents and reported pharmacological activities.

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“…Aqueous leaf extract of I. coccinea possesses considerable antinociceptive activity (when evaluated in hot plate and formalin test but not in tail flick test), with a rapid onset (within 1 h) and a fairly long duration of action (up to 5 h) with a peak effect at 3 h. The activity was dose dependent, with no harmful side effects or toxicity even following subchronic administration, mediating centrally at the supraspinal level mainly via dopaminergic mechanism .…”

Section: Biological Activitiesmentioning

confidence: 97%

Chemical Constituents of Plants from the Genus Ixora

Chen

Zhang

Chen

2016

Chemistry & Biodiversity

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Ixora is a genus of ca. 400 species in the family Rubiaceae. Since the 1940s, eighty-one compounds including phenolics, peptides, terpenoids, and sterols have been isolated from six species of the genus Ixora. Pharmacological studies have shown that these compounds and extracts from the Ixora genus have extensive activities, such as antitumor, chemoprotective, and antioxidant activities. In this review, we summarize the phytochemical progress and list the compounds isolated from the genus Ixora. The biological activities of this genus are also covered.

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Antinociceptive action of aqueous extract of the leaves ofIxora coccinea

Cited by 24 publications

References 18 publications

Anti-nociceptive and antioxidant activities of an aqueous leaf extract of <i>Corchorus olitorius </i>L. (Tiliaceae)

Anti-nociceptive and antioxidant activities of an aqueous leaf extract of <i>Corchorus olitorius </i>L. (Tiliaceae)

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Chemical Constituents of Plants from the Genus Ixora

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