Antinociception induced by PAG-microinjected dipyrone (metamizol) in rats: involvement of spinal endogenous opioids

Hernández, Norma Edenia Batista; Vanegas, Horacio

doi:10.1016/s0006-8993(01)02085-6

Cited by 33 publications

(18 citation statements)

References 11 publications

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“…The antinociception induced by metamizol or paracetamol may result from a combined spinal and peripheral effect in the primary peripheral sensory neuron either via nitric oxide pathway (Lorenzetti and Ferreira 1985;Godfrey et al 2007) or inhibition of cyclooxygenase (Warner and Mitchell 2004;Botting 2003;Pierre et al 2007). In addition, the antinociceptive activity of both paracetamol and metamizol appears to be related to the opioid and serotonergic systems (Pini et al 1997;Hernández and Vanegas 2001;Bertolini et al 2006). Furthermore, the present results are not concordant with the hypothesis that the hydroperoxides formed from these lipoxygenases could attenuate the action of paracetamol in the lack of an antiinflammatory effect of the drug (Boutaud et al 2002).…”

Section: Discussioncontrasting

confidence: 68%

Synergism between COX-3 inhibitors in two animal models of pain

et al. 2010

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These actions can be related to the differential selectivity of the drugs for inhibition of COX isoforms and also to the several additional antinociception mechanisms and pathways initiated by the analgesic drugs on pain transmission. Since the efficacy of the combination of metamizol with paracetamol has been demonstrated in the present study, this association could have a potential beneficial effect on the pharmacological treatment of clinical pain.

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Section: Discussioncontrasting

confidence: 68%

Synergism between COX-3 inhibitors in two animal models of pain

et al. 2010

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“…In addition to the well-known peripheral effects of NSAIDs—especially prostaglandin synthesis inhibition—and the fact that dipyrone is able to induce a significant antinociceptive effect in the absence of an anti-inflammatory response, it has been proposed that it produces antinociception at least partially by acting upon central nervous system structures [43, 44]. …”

Section: Resultsmentioning

confidence: 99%

Biological Activities ofLibidibia (Caesalpinia) ferreavar.parvifolia(Mart. ex Tul.) L. P. Queiroz Pod Preparations

Freitas

Ximenes

Aguiar

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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Libidibia ferrea has been used in folk medicine throughout Brazil, and this study evaluated the biological activities of crude extract (CE) as well as a partially purified fraction (F80) obtained from its pods. Results from the MTT assay revealed that only F80 inhibited NCI-H292 cell growth; however, neither CE nor F80 reduced HEp-2 cell growth or sarcoma 180 tumor weight with the in vivo assay. Acute oral toxicity of the extract and fraction was evaluated following the steps of Guideline 423, using female mice; LD50 for both preparations was determined as 2,500 mg/kg body weight. CE and F80 promoted a reduction of the leukocyte number and nitrite level in inflammatory exudates when the anti-inflammatory assay (carrageenan-induced peritonitis) was performed. CE and F80 inhibited writhing regarding antinociceptive activity (acetic acid-induced writhing response in mice). In conclusion, CE and F80 have no significant cytotoxic or antitumor activities in cell lines showing low toxicity and no action against tumors in vivo. Both preparations revealed anti-inflammatory and antinociceptive activities, corroborating the pharmacological basis of L. ferrea for ethnomedical use.

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“…Previously, it was demonstrated that the antinociceptive effect of the combination of morphine (MOR) and metamizol (MET), 5.6 + 562.3 mg/kg s.c. respectively, was significantly higher than that observed with the drugs administered individually at the same doses in arthritic rats, either after single or chronic treatments . In this case, the pharmacodynamic mechanism for the interaction between MOR and MET was partially attributed to opioidergic system participation . Other mechanisms such as the l ‐arginine‐NO‐cyclic GMP pathway and interaction with N ‐methyl d ‐aspartic acid receptors were proposed to explain the synergism and the delay in the development of tolerance observed with the combination of such drugs.…”

Section: Introductionmentioning

confidence: 80%

Pharmacokinetics and pharmacodynamics of metamizol in co-administration with morphine under acute and chronic treatments in arthritic rats

Carrillo-Calzadilla

López‐Muñoz

Moreno-Rocha

et al. 2017

Journal of Pharmacy and Pharmacology

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The mechanism involved in the potentiation of the antinociceptive effect produced by the combination, cannot be explained by the interaction of morphine on metamizol pharmacokinetics. Other pharmacokinetic interactions along with known pharmacodynamic interactions in which metamizol active metabolites contribute, should be considered. The frequency of administration enhances tolerance development and induces metamizol elimination process.

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Antinociception induced by PAG-microinjected dipyrone (metamizol) in rats: involvement of spinal endogenous opioids

Cited by 33 publications

References 11 publications

Synergism between COX-3 inhibitors in two animal models of pain

Synergism between COX-3 inhibitors in two animal models of pain

Biological Activities ofLibidibia (Caesalpinia) ferreavar.parvifolia(Mart. ex Tul.) L. P. Queiroz Pod Preparations

Pharmacokinetics and pharmacodynamics of metamizol in co-administration with morphine under acute and chronic treatments in arthritic rats

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