Antineutrophil cytoplasmic antibody-associated vasculitides and IgG4-related disease: A new overlap syndrome

Danlos, François‐Xavier; Rossi, Giovanni Maria; Blockmans, Daniel Engelbert; Emmi, Giacomo; Kronbichler, Andreas; Durupt, S.; Maynard, Claire; Luca, L. De; Garrouste, Cyril; Lioger, Bertrand; Mourot-Cottet, Rachel; Dhôte, Robin; Arlet, Jean‐Benoît; Hanslik, Thomas; Rouvier, Philippe; Ebbo, Mikaël; Puéchal, Xavier; Nochy, Dominique; Carlotti, A.; Mouthon, Luc; Guillevin, Loı̈c; Vaglio, Augusto; Terrier, Benjamin

doi:10.1016/j.autrev.2017.07.020

Cited by 126 publications

(71 citation statements)

References 43 publications

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“…While granuloma formation seen in biopsy means the exclusion of IgG4‐RD, the presence of other features for IgG4‐RD (especially lymphoplasmacytic infiltration) could be a source of confusion for AAV diagnosis. After all, the authors who declare the overlap of these two disease stated that: “… histologic patterns did not overlap in the same tissue samples” . It should be kept in mind that the criterion used for AAV diagnosis is a classification criterion.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, Danlos et al hypothesized that there may be an overlap between AAV and IgG4‐RD . We performed a systematic literature review in PUBMED database covering the time period from 1976 until April 2018 (Table ).…”

Section: Methodsmentioning

confidence: 99%

“…6 Recently, Danlos et al hypothesized that there may be an overlap between AAV and IgG4-RD. 4 We performed a systematic literature review in PUBMED database covering the time period from 1976 until April 2018 (Table 1). Relevant publications were searched using these MeSH terms: ''IgG4-related disease and Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis'', "IgG4-related disease and Eosinophilic Granulomatosis with Polyangiitis", "IgG4-related disease and Microscopic Polyangiitis" and "IgG4-related disease and Granulomatosis with Polyangiitis".…”

Section: Patient Selectionmentioning

confidence: 99%

“…Due to these similar clinical features sometimes it may be difficult to differentiate these two diseases. The co‐occurrence/ concurrence of AAV and IgG4‐RD was recently published by the collaborative European Vasculitis Study Group …”

Section: Introductionmentioning

confidence: 96%

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Do ANCA‐associated vasculitides and IgG4‐related disease really overlap or not?

et al. 2019

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Background Antineutrophil cytoplasmic antibody (ANCA)‐associated vasculitis (AAV) and immunoglobulin G4‐related disease (IgG4‐RD) have some common features. The co‐occurrence/concurrence of AAV and IgG4‐RD was recently published by the collaborative European Vasculitis Study Group. First, we aimed to investigate ANCA positivity of our IgG4‐RD cohort. Second, a literature review of co‐occurrence/concurrence of AAV and IgG4‐RD was done. Methods Data of 62 patients with IgG4‐RD in Hacettepe Vasculitis Center Database were used. Patient dataset was designed to include demographic data, clinical characteristics, imaging and IgG4‐RD, AAV and ANCA test results. At the next step, we performed a systematic literature review in PUBMED database covering the time period from 1976 until April 2018. Relevant publications were searched using these MeSH terms ‘‘IgG4‐related disease and Anti‐Neutrophil Cytoplasmic Antibody‐Associated Vasculitis’’, “IgG4‐related disease and Eosinophilic Granulomatosis with Polyangiitis”, “IgG4‐related disease and Microscopic Polyangiitis” and “IgG4‐related disease and Granulomatosis with Polyangiitis”. Results Three (10.3%) of 29 patients had low titer ANCA positivity. These three patients didn't have any findings of vasculitis and no granuloma was seen in biopsy. In the literature review, we found 17 cases had features of both IgG4‐RD and AAV. These cases were re‐evaluated according to the Comprehensive Diagnostic Criteria for IgG4‐RD. ANCA were positive in 15 of 17 patients (88%). Conclusion None of our IgG4‐RD patients overlapped with AAV. Only two patients in the literature review seemed to be fully compatible with both diseases. Even though AAV and IgG4‐RD share similar clinical features, we think this might be a co‐occurrence instead of a histopathological link.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Patient Selectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

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Do ANCA‐associated vasculitides and IgG4‐related disease really overlap or not?

et al. 2019

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“…There can be overlap between GPA and IgG4-related disease. Chronic periaortitis, tubulointerstitial nephritis, and prevertebral fibrosis are characteristics of IgG4-related disease rather than of ANCA-associated vasculitis [65]. Rarely extranodal natural killer/T-cell lymphoma can present with midline destructive lesion.…”

Section: Differential Diagnosismentioning

confidence: 99%

Vasculitis

Hoang

Park

2020

Hospital-Based Dermatopathology

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Eosinophilic granulomatous polyangiitis with IgG4 hypergammaglobulinaemia and salivary gland swelling

Takahashi

Sadamatsu

Tashiro

et al. 2020

Respirology Case Reports

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A 51-year-old woman was admitted to our hospital for cough, fever, purpura in the legs, and salivary gland swelling. Six years ago, she had been diagnosed with bronchial asthma and was treated with a combination of inhaled corticosteroid and long-acting beta2-agonist. Blood examination showed increased eosinophils at 3027 cells/μL and elevated levels of immunoglobulin (Ig) G4 at 261 mg/dL and C-reactive protein at 2.76 mg/dL. Chest radiograph and computed tomography (CT) showed infiltrates in the bilateral lower lobes. Neck CT showed bilateral salivary gland swelling. Pathological examinations of the lungs and skin purpura showed granuloma with eosinophilic infiltration and perivascular dermatitis, respectively. She was diagnosed with eosinophilic granulomatous polyangiitis (EGPA) and treated with corticosteroids, which resolved the eosinophilia, salivary gland swelling, elevated IgG4 titre, and lung infiltration. As our patient did not meet the American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) 2019 criteria of IgG4-related disease, the diagnostic was EGPA with IgG4 hypergammaglobulinaemia and salivary gland swelling.

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Antineutrophil cytoplasmic antibody-associated vasculitides and IgG4-related disease: A new overlap syndrome

Cited by 126 publications

References 43 publications

Do ANCA‐associated vasculitides and IgG4‐related disease really overlap or not?

Do ANCA‐associated vasculitides and IgG4‐related disease really overlap or not?

Vasculitis

Eosinophilic granulomatous polyangiitis with IgG4 hypergammaglobulinaemia and salivary gland swelling

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