1995
DOI: 10.1002/art.1780380509
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Antineutrophil cytoplasmic antibodies in systemic lupus erythematosus

Abstract: The absence of cANCA, anti-PR3, and anti-MPO shows that with appropriate assay conditions, ANCA testing assists in the differentiation between SLE and the ANCA-associated vasculitides. The lack of a correlation between pANCA or any ANCA subspecificity and clinical manifestations suggests that ANCA do not identify particular clinical subsets among SLE patients, including those with lupus vasculitis.

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Cited by 104 publications
(91 citation statements)
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References 12 publications
(15 reference statements)
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“…Neutrophils are abundantly recruited to infection sites and have also been associated with SLE (3)(4)(5). Furthermore, SLE patients develop Abs against chromatin and neutrophil proteins (4,5,27), the components of NETs. We propose that defects in NETs clearance exacerbate the disease.…”
Section: Discussionmentioning
confidence: 99%
“…Neutrophils are abundantly recruited to infection sites and have also been associated with SLE (3)(4)(5). Furthermore, SLE patients develop Abs against chromatin and neutrophil proteins (4,5,27), the components of NETs. We propose that defects in NETs clearance exacerbate the disease.…”
Section: Discussionmentioning
confidence: 99%
“…2 Following the detection of ANCA in systemic vasculitis, it became clear that ANCA also occurred in other idiopathic inflammatory disorders, 3 including inflammatory bowel diseases or IBD (which include ulcerative colitis (UC) and Crohn's disease (CD)), 4,5 in autoimmune-mediated liver diseases, [6][7][8] in rheumatoid arthritis (RA), 9,10 and in systemic lupus eythematosus (SLE). 11,12 ASCA of IgG and IgA isotype are present in 60% of cases with diagnosed CD, 13 and directed against phosphopeptidomannans present in the yeast (S. cerevisiae) cell walls. 13,16 ASCA may be elicited due to molecular mimicry and priming by a high mannose-containing bacterial or viral antigen or an "auto-antigenic (self) molecule".…”
Section: Introductionmentioning
confidence: 99%
“…Some patients with connective tissue disorders have an atypical ANCA in which the IIF staining pattern does not resemble typical C-or P-ANCA (11,82). By IIF, P-ANCA may be identified in patients with systemic lupus erythematosus and may be difficult to distinguish from ANA (2,3,15,35,36,83). P-ANCA can be seen in various connective tissue diseases, such as in rheumatoid arthritis, inflammatory arthritis, progressive systemic sclerosis, and other disorders (4,33,38,84).…”
Section: Discussionmentioning
confidence: 99%