Antineutrophil cytoplasmic antibodies in Chinese patients with tuberculosis

Gao, Huan; Gao, Yang; Qu, Xiaoyu; Xu, Jiancheng; Song, Yanqing

doi:10.1590/0037-8682-0400-2017

Cited by 11 publications

(4 citation statements)

References 14 publications

(17 reference statements)

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“…The fact that the second ANCA test came back positive led to early closure of our clinical reasoning. The association between positive ANCA serology and infections such as tuberculosis and MAC has been described previously [9,10]. However, it is not clear whether the presence of ANCA truly reflects a vasculitis induced by mycobacteria or merely a clinical non-significant antibody induced by the infection.…”

Section: Discussionmentioning

confidence: 95%

Not Everything Is as It Seems: A Case Series and Overview of Diseases Mimicking Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

Houben,

de Groot,

Vegting

et al. 2023

JCM

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Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare heterogeneous disease in which treatment must be initiated early to prevent irreversible organ damage and death. There are several diseases that can mimic AAV, even in the presence of positive ANCA serology and/or histological evidence of vasculitis, as demonstrated in this case series. We reflect on the diagnostic approach of patients with AAV and provide an overview of AAV-mimicking diseases that can be considered in patients with atypical disease presentation or course.

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Section: Discussionmentioning

confidence: 95%

Not Everything Is as It Seems: A Case Series and Overview of Diseases Mimicking Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

Houben,

de Groot,

Vegting

et al. 2023

JCM

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“…In another study, Gao Huan et al determined the presence of ANCAs in patients with TB. Even though the measure of ANCAs was not performed in our research, it would be worth investigating an association among ANCAs positive vasculitis, TB diagnosis, and the expression of the TNF-α soluble receptors in further studies [29].…”

Section: Discussionmentioning

confidence: 99%

The role of TNF receptors as mediators of chronic vasculitis in possible milder forms of the CNS tuberculosis

Rivas-Castro,

Salinas-Lara,

Sánchez Garibay

et al. 2023

J Infect Dev Ctries

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Introduction: Central nervous system (CNS) tuberculosis (TB) is the most severe form of TB due to its high mortality and functional sequelae. There are several differential diagnoses for TB; and, it can also cause secondary conditions, such as vasculitis. Methodology: 155 biopsies, corresponding to 155 different patients out of 5,386 registered biopsies from 2008-2013, met the criteria of unknown etiology vasculitis and evidence of cerebral vascular disease. These were analyzed to assess the presence of central nervous system TB. The selected cases were assessed with Suzaan Marais (SM) criteria for clinical tuberculosis. After that, Ziehl-Neelsen (ZN) staining and polymerase chain reaction (PCR) were performed to amplify a fragment of the insertion sequence IS6110 of M. tuberculosis. 21 patients met the criteria for definitive tuberculosis by ZN staining and PCR, and 2 met the criteria for possible tuberculosis. Tumor necrosis factor (TNF)-α, TNF-R1, and TNF-R2 were determined by immunohistochemistry in histological sections from formalin-fixed paraffin-embedded (FF-PE) tissues in the 23 selected patients. Results: Granulomatous TB was present in almost half of the cases. TNF-R1 and TNF-R2 were expressed mainly in blood vessels, histiocytes, and macrophages. TNF-R2 expression was higher than the other markers, which suggests an anti-inflammatory response against M. tuberculosis Conclusions: The histopathological presentation of TB is not always limited to granulomas, abscesses, or meningitis; there are also clinical presentations characterized only with chronic inflammation of nervous and vascular tissue.

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“…In an analysis of 50 AAV case reports, three species of bacteria (Streptococci, Staphylococci, and Enterococci) were associated with 63% of the reported episodes of infectious endocarditis and 42% of all infections reported. 25 Huan et al 26 recently demonstrated that ANCA-positivity in patients with Mycobacterium tuberculosis infection is related to AAV, so the detection of ANCA in these patients must be excluded because GPA and MPA can present with clinical features that overlap with those of tuberculosis. Among the viruses suspected to play a pathogenic role in AAV, parvovirus B19, 27 Epstein-Barr virus, 28 and Ross River virus have been reported.…”

Section: Environmental Associations and Immunogenicity Of Anti-neutro...mentioning

confidence: 99%

Genetic Associations and Environmental Exposures in the Aetiopathogenesis of Anti-Neutrophil Cytoplasmic Antibody- Associated Vasculitis: An Updated Review

Salvadori

Tsalouchos²

2018

EMJ

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Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) represents a heterogeneous group of rare diseases characterised by necrotising inflammation of the small blood vessels and the presence of ANCA with specificity for proteinase-3 or myeloperoxidase. Genetic susceptibility along with malignancy, drug exposure, and environmental exposures to infectious agents and silica are involved in disease progression. To date, growing evidence has revealed that ANCA specificity defines homogeneous groups of patients more effectively than clinical diagnosis, since proteinase-3 ANCA and myeloperoxidase-ANCA are linked with different genetic backgrounds and epidemiologies. This review presents current and updated knowledge on the central aetiopathogenic role of genetic associations and environmental exposures in AAV; discusses the main mechanisms of ANCA immunogenesis; and highlights the value of ANCA specificity for future classification criteria.

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Antineutrophil cytoplasmic antibodies in Chinese patients with tuberculosis

Cited by 11 publications

References 14 publications

Not Everything Is as It Seems: A Case Series and Overview of Diseases Mimicking Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

Not Everything Is as It Seems: A Case Series and Overview of Diseases Mimicking Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

The role of TNF receptors as mediators of chronic vasculitis in possible milder forms of the CNS tuberculosis

Genetic Associations and Environmental Exposures in the Aetiopathogenesis of Anti-Neutrophil Cytoplasmic Antibody- Associated Vasculitis: An Updated Review

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