Antineutrophil Cytoplasmic Antibodies, Anti-Saccharomyces cerevisiae Antibodies, and Specific IgE to Food Allergens in Children with Inflammatory Bowel Diseases

Bartůňková, Jiřina; Kolářová, I.; Šedivá, Anna; Hölzelova, Eliska

doi:10.1006/clim.2001.5145

Cited by 44 publications

(29 citation statements)

References 37 publications

(32 reference statements)

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“…In pediatric patients things might be different and it has been reported that the combination of these two tests increases the specificity to 95% and the PPV to 96%, suggesting a possible role to differentiate IBD from other diseases presenting with chronic diarrhea [5, 8]. …”

Section: Discussionmentioning

confidence: 99%

“…Things may be different in children with IBD, where these tests could be clinically useful to differentiate between IBD and other diarrheal illnesses [1, 5]. Actually, many [6,7,8,9,10,11,12,13,14,15] but not all [16] available studies in IBD pediatric populations reported that testing for these antibodies yields significantly useful clinical information and may avoid further unnecessary examinations.…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic Value of Serological Assays in Pediatric Inflammatory Bowel Disorders

Mainardi

Villanacci²,

Bassotti

et al. 2007

Digestion

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Background: Pediatric studies reported that the combined use of the anti-neutrophil cytoplasm autoantibodies (ANCA) and the anti-Saccharomyces cerevisiae mannan antibodies (ASCA) may be a specific useful noninvasive test in the diagnosis of inflammatory bowel diseases (IBD). Aims: To evaluate the diagnostic accuracy of ANCA and ASCA in children with suspected IBD, and to see whether different commercially available assays (indirect immunofluorescence vs. ELISA) agree well enough in terms of analytical performance. Patients and Methods: Sixty-nine children (30 males, 39 females, age range 2–18 years) with suspicion of IBD entered the study. Before colonoscopy, a blood sample was also drawn to assess ASCA and ANCA. Results: A diagnosis of IBD was established in 47 patients; the remainder had infective or other causes of colitis. For ulcerative colitis, the association ASCA–/ANCA+ had 70% sensitivity and 86% specificity, with a positive predictive value of 82%. The association ASCA+/ANCA– had 86% sensitivity and 93% specificity for Crohn’s disease, with a positive predictive value of 75%. Conclusion: Although more experience is needed to state the diagnostic power of serologic assay, determination of ANCA and ASCA in IBD children may help both in distinguish these conditions from other entitiesand ulcerative colitis from Crohn’s disease, particularly in doubtful cases.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diagnostic Value of Serological Assays in Pediatric Inflammatory Bowel Disorders

Mainardi

Villanacci²,

Bassotti

et al. 2007

Digestion

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“…8 However, the relative lack of evidence in East European IBD patients, at least for ASCA, [9][10][11][12] makes it difficult to define whether the diagnostic yield is comparable to that seen in West European and North American white patients. Further corroborating studies are required, as Abbreviations: UC, ulcerative colitis; CD, Crohn's disease; CT, computed tomography; US, ulstrasound; MRI, magnetic resonance imaging; IBD, inflammatory bowel disease significant geographical heterogeneity is reported from different countries and ethnic groups, with lower prevalence of pANCA.…”

Section: Diagnosis Of Ibd In Eastern Europementioning

confidence: 99%

Management of inflammatory bowel diseases in Eastern Europe

Lakatos

2006

Postgraduate Medical Journal

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Limited data are available on the management of inflammatory bowel diseases (IBD) in East European countries. The diagnostic tools and most treatment options are also available in Eastern Europe. The diagnostic procedures commonly used became more sophisticated in the past few years, with a greater use of computed tomography/magnetic resonance imaging and serology testing; however, double contrast barium enema, enteroclysis, and endoscopy remained standard. The medical therapy and surgical strategies are also somewhat different from those applied in Western countries. In ulcerative colitis, besides mesalazine, the use of sulphasalazine is still frequent, while azathioprine is only used in a minority of patients. The use of conventional corticosteroids is common and the rate of non-colorectal cancer associated colectomies is low. In contrast, 5-aminosalicylates are still used for maintenance in Crohn's disease and azathioprine is generally less frequently given compared with Western Europe. Biological agents have also become available about five years ago, yet their use is restricted mainly to specialised centres.

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“…Antimicrobial antibodies do not seem to be associated with clinical disease activity at the time of sample procurement (table 1) [60,98,119,120]. Interestingly, pediatric CD patients positive for ASCA were more than twice as likely to experience a relapse during follow-up than ASCA-negative patients [121].…”

Section: Disease Activity and Response To Therapymentioning

confidence: 99%

Circulating Antibodies against Bacterial Wall Products: Are There Arguments for Early Immunosuppression?

Rieder

Kugathasan²

2012

Dig Dis

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The disease course of inflammatory bowel disease (IBD) is highly heterogeneous and unpredictable. The risk of fistulae formation and stricturing complications that lead to surgery during the disease course is substantial. Use of early and aggressive immunosupressive therapies such as immunomodulation could have the potential for altering the natural history of IBD, namely reducing the number of hospitalizations and surgeries. If diagnostic tools are available to predict disease activity, response to therapy, disease complications as well as the need for surgery or hospitalizations, one could identify IBD patients at risk that might benefit from more intense immunosuppression. Circulating antibodies against bacterial wall products, such as anti-Saccharomyces cervisiae antibodies have been investigated for the diagnosis and disease stratification of IBD. These markers are mainly linked to Crohn’s disease (CD), are associated with genetic polymorphisms such as NOD2, and are linked to and possibly predictive of complicated CD behavior and CD-related surgery. No association of these antibodies has been found on assessment of disease activity, tissue healing or surgical recurrence. Perinuclear antineutrophil cytoplasmic antibodies are linked to ulcerative colitis (UC) and are associated with a severe UC disease course, the need for surgery and (potentially) the response to therapy, but not disease activity. Serological antimicrobial antibodies are promising tools for the identification and prediction of risk for the development of complicated disease during the disease course in CD. To truly improve daily clinical practice serological antimicrobial antibodies need to be incorporated into clinical therapeutic trials to assess their role in identifying patients who may benefit from early immunosuppressive therapy.

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Antineutrophil Cytoplasmic Antibodies, Anti-Saccharomyces cerevisiae Antibodies, and Specific IgE to Food Allergens in Children with Inflammatory Bowel Diseases

Cited by 44 publications

References 37 publications

Diagnostic Value of Serological Assays in Pediatric Inflammatory Bowel Disorders

Diagnostic Value of Serological Assays in Pediatric Inflammatory Bowel Disorders

Management of inflammatory bowel diseases in Eastern Europe

Circulating Antibodies against Bacterial Wall Products: Are There Arguments for Early Immunosuppression?

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