Antineutrophil Cytoplasmic Antibodies (ANCA) Induce Dysregulated Neutrophil (PMN) Apoptosis

Abstract

These data are consistent with the hvpothesis that programmed alterations to renal structure are reflected in progressive deterioration HJ NEWBERY', N FISHER^, M PIRMOHAMED", NR KITTERINGHAM' IT GILMORE', D ADAMS3 and BK PARK'Evidence from twin, longitudinal and cross-sectional studies suggests that alcoholic liver disease is multifactorial in aetiology, with genetic and environmental factors interacting in its pathogenesis. A role for TNFu in this process is supported both by observations of raised levels of TNFU, correlating with disease severity, and the association of promoter region polymorphisms with the disease. Furthermore,