Antineutrophil cytoplasm autoantibodies against bactericidal/permeability-increasing protein in inflammatory bowel disease.

Walmsley, Russell; Zhao, Ming; Hamilton, M. W.; Brownlee, A; Chapman, P; Pounder, R E; Wakefield, Andrew J.; Cm, Lockwood

doi:10.1136/gut.40.1.105

Cited by 70 publications

(51 citation statements)

References 22 publications

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“…The role of BPI is highlighted in that it binds to LPS with a high affinity, thereby preventing formation of the LBP-LPS complex and markedly decreasing the proinflammatory effects of endotoxin. tory bowel disease (39) which is associated with anti-BPI antibodies in perinuclear antineutrophil cytoplasmic antibodypositive ulcerative colitis (48). Anti-BPI antibodies have also been detected in patients with cystic fibrosis (60).…”

Section: Activity In Biologic Fluidsmentioning

confidence: 99%

A Neutrophil-Derived Anti-Infective Molecule: Bactericidal/Permeability-Increasing Protein

Levy

2000

Antimicrob Agents Chemother

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Section: Activity In Biologic Fluidsmentioning

confidence: 99%

A Neutrophil-Derived Anti-Infective Molecule: Bactericidal/Permeability-Increasing Protein

Levy

2000

Antimicrob Agents Chemother

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“…This implies that data on the specificity of the antibodies studied are incomplete. One study reported anti-BPI and anti-cathepsin G antibodies in a substantial number (Ն20%) of infectious enteritis cases (26 ). Direct comparison of the sensitivities and specificities of the serologic markers described in the various studies was not possible because no ROC curves could be constructed based on the data provided in the different reports.…”

Section: Autoantigens Recognized By Autoantibodies To Neutrophils (Atmentioning

confidence: 99%

“…Overviews of the various studies (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28) ) that have attempted to identify the antigenic species recognized by atypical P-ANCAs in UC and CD patients and in controls are given in Tables 1 through 3. The antigens that have been studied are located in the granules, the cytosol, and/or the nuclei or nuclear periphery.…”

Section: Autoantigens Recognized By Autoantibodies To Neutrophils (Atmentioning

confidence: 99%

Serologic Markers in Inflammatory Bowel Disease

Bossuyt¹

2006

Clinical Chemistry

182

136

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Inflammatory bowel disease (IBD) is an enduring disease involving mostly young people, with symptoms of bloody diarrhea and abdominal cramps. Several antibodies have been associated with IBD, the 2 most comprehensively studied being autoantibodies to neutrophils (atypical perinuclear anti-neutrophil cytoplasmic antibodies) and anti-Saccharomyces cerevisiae antibodies. This review focuses on the value of these antibodies for diagnosing IBD, differentiating Crohn disease from ulcerative colitis, indeterminate colitis, monitoring disease, defining clinical phenotypes, predicting response to therapy, and as subclinical markers. Pancreatic antibodies and newly identified anti-microbial antibodies (anti-outer membrane porin C, anti-I2, and anti-flagellin) are also reviewed.

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“…Autoimmune mechanisms may play an important role in the pathogenesis of this disease. Various kinds of autoantibodies, such as anti-neutrophil cytoplasmic antibodies [1][2][3][4] and antitropomyosin antibodies, [5][6][7] have been demonstrated in serum samples of patients with ulcerative colitis.…”

Section: Introductionmentioning

confidence: 99%

Circulating autoantibodies against purified colonic mucin in ulcerative colitis

et al. 2000

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To clarify the role of colonic mucin in the autoimmune process of ulcerative colitis, circulating antibodies against human colonic mucin were investigated. Purified colonic mucin, obtained from human colonic mucosa by gel filtration, using a Bio-Gel A-1.5-m column and CsCl equilibrium density gradient, was divided into soluble mucin (S-mucin) secreted extracellularly and membranous mucin (M-mucin) binding to cell membrane. Sodium dodecylsulfate polyacrylamide gel electrophoresis and Western blotting analysis showed that antibodies in the serum samples of some patients with ulcerative colitis recognized purified S- and M-mucin of >180-kD. By enzyme-linked immunosorbent assay (ELISA), anti-mucin antibodies were detected in 11 of 60 patients with ulcerative colitis (18%). In contrast, the antibodies were not detected in 22 patients with Crohn's disease. The titers of antimucin antibodies against S-mucin and M-mucin were not different in each patient. By ELISA using mucin in which the sugar chains were destroyed by neuraminidase or NaIO4 treatment, it was demonstrated that anti-mucin antibodies recognized the epitopes of either the sugar chain or the core protein exposed through destruction of the sugar chains. We then investigated the relationship between anti-mucin antibodies and the patients' clinical features. Anti-mucin antibodies were detected in 6 of 15 patients with chronic continuous type ulcerative colitis (40%) and in 5 of 26 patients with relapsing-remitting type (19%), but there was no antimucin antibody-positive serum in patients who had had only one attack without any relapse. These results suggest that anti-mucin antibodies could be a disease marker for ulcerative colitis and that immunological abnormalities in colonic mucin contribute to the persistence of colonic mucosal inflammation.

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Antineutrophil cytoplasm autoantibodies against bactericidal/permeability-increasing protein in inflammatory bowel disease.

Abstract: Background-Bactericidallpermeability-

Cited by 70 publications

References 22 publications

A Neutrophil-Derived Anti-Infective Molecule: Bactericidal/Permeability-Increasing Protein

A Neutrophil-Derived Anti-Infective Molecule: Bactericidal/Permeability-Increasing Protein

Serologic Markers in Inflammatory Bowel Disease

Circulating autoantibodies against purified colonic mucin in ulcerative colitis

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