Antineoplastic therapy in childhood cancer patients presents a negative impact in the periodontal tissues: a cohort study

Longo, Bruna C.; Rohling, Isabel B.; Silva, Pauline L. M. O. E.; de Morais, Maria E. F.; Paz, Hélvis E. S.; Casarin, Renato C. V.; Nishiyama, Sheila A. B.; de Souza, Maria D. B.; Silva, Cléverson O.

doi:10.1007/s00784-023-05270-1

Cited by 2 publications

(1 citation statement)

References 45 publications

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“…There is also evidence that oncological treatment has a causal relationship with several other inadvertent effects, such as mucositis, affecting every location of the oral mucosa; infections; neurological disturbances and dysgeusia; hyposialia and xerostomia; bleeding tendencies; and osteonecrosis development [41]. Longo et al concluded that antineoplastic therapy in patients with childhood cancer has a negative impact on the periodontium and various microbiological parameters [42]. Fifty-three percent of patients who underwent total body irradiation at a young age had a decreased mouth opening and reduced width of translational movements.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Orthodontic Treatment in Cancer Survivors: A Systematic Review

Karvelas,

Ntanasis-Stathopoulos,

Makrygiannakis

et al. 2024

JCM

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Background: Survival rates of cancer patients have increased globally and across age groups. Challenges arising from craniofacial growth-development disturbances and dental abnormalities might warrant modifications to standard orthodontic pathways of care. Objective: The aim of this study was to systematically summarize and critically assess the available literature regarding the characteristics of orthodontic treatment in cancer survivors. Materials and Methods: A systematic search was conducted in seven databases for studies on malignant tumor survivors having undergone orthodontic intervention with fixed appliances following cancer treatment up to August 2023. The outcomes of interest included quantitative data regarding various characteristics of orthodontic treatment and the post-treatment period. The risk of bias was assessed individually with the Newcastle-Ottawa scale. Results: Out of 347 records, 4 cohort studies were eventually included in the qualitative synthesis. Leukemia was the most common malignancy type, with treatment involving mainly chemotherapy and/or radiotherapy. The duration of orthodontic treatment in cancer survivors varied. Occlusal results, quality of life, and satisfaction were comparable to healthy peers. However, in some survivors’ groups, treatment was shorter and the final results were compromised. Root resorption and oral mucositis were reported among the treated cancer survivors. Reduced occlusal outcome stability during the retention period was also reported. Conclusions: Overall, the duration of orthodontic treatment varied among cancer survivors. The occlusal results achieved were similar to those of their healthy peers, though potentially less stable. Patient-reported outcomes did not differ significantly between cancer survivors and healthy individuals treated orthodontically.

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Section: Discussionmentioning

confidence: 99%

Characteristics of Orthodontic Treatment in Cancer Survivors: A Systematic Review

Karvelas,

Ntanasis-Stathopoulos,

Makrygiannakis

et al. 2024

JCM

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Integrating Periodontal Therapy and Biofilm Management into Breast Cancer Patients' Care: Periodontal, Hematological and salivary Parameters Assessment Before and During Chemotherapy

Villafuerte,

Reis,

Carrara

et al. 2024

Preprint

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Objective To evaluate the impact of chemotherapy on periodontal conditions, hematology, and salivary flow in patients with breast cancer and gingivitis, after basic periodontal therapy (BPT). Methods They were divided into patients with breast cancer and gingivitis (BC/G = 20); and patients without cancer with gingivitis (G = 20). Clinical parameters [Plaque Index (PI), bleeding on probing (BOP), Probing Depth (PD), Clinical Attachment Level (CAL)], hematological parameters, and salivary flow were evaluated at baseline, 6, 12 and 24 weeks. Results After BPT, both groups exhibited a reduction in BOP and PI. However, group G showed a significantly (p < 0.05) greater reduction at weeks 12 and 24 compared to group BC/G. In the hematological parameters, the G group showed higher hemoglobin and red blood cell levels than the BC/G group at 6, 12, and 24 weeks (p < 0.05). The salivary flow rate was decreased at 6, 12, and 24 weeks in BC/G (< 0.3 ml/min), however, they did not show hyposalivation (< 0.1ml/min). Conclusion Chemotherapy significantly impacts periodontal and hematological conditions, as well as salivary flow. Both groups, showed improvement in periodontal conditions after BPT, with a reduction in BOP and PI. However, the group without cancer demonstrated significantly greater improvement compared to the group with cancer, indicating that chemotherapy affects inflammatory control. The application of BPT with strict biofilm control is necessary for breast cancer patients, contributing to an overall favorable treatment outcome.

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Antineoplastic therapy in childhood cancer patients presents a negative impact in the periodontal tissues: a cohort study

Cited by 2 publications

References 45 publications

Characteristics of Orthodontic Treatment in Cancer Survivors: A Systematic Review

Characteristics of Orthodontic Treatment in Cancer Survivors: A Systematic Review

Integrating Periodontal Therapy and Biofilm Management into Breast Cancer Patients' Care: Periodontal, Hematological and salivary Parameters Assessment Before and During Chemotherapy

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