Antineoplastic Properties of Parthenin Derivatives – The Other Faces of a Weed

Bhusan, S.; Sachin, Bhusari S.; Kessar, R. R.; Reddy, D. Mahendhar; Kumar, Halmuthur M. Sampath; Saxena, Ajit Kumar

doi:10.1007/978-3-642-23394-4_3

Cited by 1 publication

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“…Several spiro-derivatives of parthenin (benzonitrile oxides, nitrones, and azides with an exocyclic double bond of C ring (α-methylene-γ-butyrolactone)) exhibited improved anti-cancerous activity against human cancer cell lines with low mammalian toxicity compared with parthenin [ 6 ]. SLPAR13 ( Figure 5 c), a spiro-isoxazolidine derivative of parthenin, caused cell death in three human cancer cell lines, namely HL-60, SiHa, and HeLa [ 51 ]. Khazir and co-workers found that 1,2,3-triazole derivatives of coronopilin ( Figure 5 d), synthesised from parthenin, were effective against PC-3 cell lines (IC 50 value = 3.1 μM) as well as against the NF-κB (p65) transcription factor (with 80% inhibition in 24 h at 100 μM) [ 52 ].…”

Section: Pharmacological Properties Of Partheninmentioning

confidence: 99%

Parthenin—A Sesquiterpene Lactone with Multifaceted Biological Activities: Insights and Prospects

Kaur

Jandrotia

et al. 2021

Molecules

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Parthenin, a sesquiterpene lactone of pseudoguaianolide type, is the representative secondary metabolite of the tropical weed Parthenium hysterophorus (Asteraceae). It accounts for a multitude of biological activities, including toxicity, allergenicity, allelopathy, and pharmacological aspects of the plant. Thus far, parthenin and its derivatives have been tested for chemotherapeutic abilities, medicinal properties, and herbicidal/pesticidal activities. However, due to the lack of toxicity–bioactivity relationship studies, the versatile properties of parthenin are relatively less utilised. The possibility of exploiting parthenin in different scientific fields (e.g., chemistry, medicine, and agriculture) makes it a subject of analytical discussion. The present review highlights the multifaceted uses of parthenin, on-going research, constraints in the practical applicability, and the possible workarounds for its successful utilisation. The main aim of this comprehensive discussion is to bring parthenin to the attention of researchers, pharmacologists, natural product chemists, and chemical biologists and to open the door for its multidimensional applications.

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Section: Pharmacological Properties Of Partheninmentioning

confidence: 99%