Antineoplastic properties and pharmacological applications of Crotalus durissus terrificus snake venom

Abstract

The all authors confirm sole responsibility for the following: study conception and design, data (references) collection, analysis and interpretation of results, and manuscript preparation. Conflict of Interest:The authors declare that there are no conflicts of interest regarding the publication of this manuscript.

Cytotoxic effects of crotoxin from Crotalus durissus terrificus snake in canine mammary tumor cell lines

“…As a source of multiple biological molecules, snake venom is a tremendous opportunity for new medical uses by improvement with a biotechnological process [ 9 , 10 , 11 , 12 , 13 , 14 ]. Crotalus durissus terrificus , a Viperidae snake (Crotalinae subfamily) also called Rattlesnake, and its venom (CdtV) comprises more than 60 different proteins with multiple pharmaceutical uses, such as antitumor, antiviral, and antimicrobial activities [ 9 , 15 , 16 ].…”

“…As a source of multiple biological molecules, snake venom is a tremendous opportunity for new medical uses by improvement with a biotechnological process [ 9 , 10 , 11 , 12 , 13 , 14 ]. Crotalus durissus terrificus , a Viperidae snake (Crotalinae subfamily) also called Rattlesnake, and its venom (CdtV) comprises more than 60 different proteins with multiple pharmaceutical uses, such as antitumor, antiviral, and antimicrobial activities [ 9 , 15 , 16 ]. Crotoxin (CTX) is a potent β-neurotoxin formed by the junction of two subunits: one basic (CB-PLA 2 ) enzymatic part and another acidic (crotapotin) with structural properties, exhibits nephrotoxic, cardiotoxic, and myotoxic effects [ 17 ] and this complex protein represents approximately 50% of dry crude venom [ 9 , 12 , 18 , 19 , 20 , 21 ].…”

A Comparative Analysis of the Cytotoxic and Vascular Activity Effects of Western Diamondback Rattlesnake (Crotalus atrox) and Eastern Diamondback Rattlesnake (Crotalus adamanteus) Venoms Using a Chick Embryo Model

“…The Crotalus genus comprises a group of venomous pit vipers, commonly known as rattlesnakes or rattlers, belonging to the viper family and naturally found in the Americas [ 1 , 2 , 3 , 4 ]. The western diamondback rattlesnake ( Crotalus atrox ) and the eastern diamondback rattlesnake ( Crotalus adamanteus ) represent species of this genus occupying distinct geographical niches [ 5 , 6 ].…”

“…The venom components of the Crotalus genus, like other zoonotic venoms, represent a source of potential biotechnological benefits due to their specialized and targeted interactions with numerous physiological targets [ 21 ]. While the World Health Organization (WHO) has classified snakebites as a neglected tropical disease [ 4 , 22 ], understanding the effects of these snake venoms on tissues is crucial not only from a clinical standpoint.…”