Antineoplastic Drug-induced Aortitis: An Unraveled Adverse Effect Using the World Health Organization Pharmacovigilance Database

Abstract

Aortitis is a rare inflammatory disease ranging from asymptomatic aortic thickening to life-threatening manifestations, especially aortic dissection or stenosis. Aortitis mainly occurs during systemic inflammatory diseases (giant cell arteritis, Takayasu arteritis, IgG4-related disease) and less frequently in patients with syphilis or tuberculosis1. Aortitis is rarely suspected to be induced by drugs and its causality is hardly assessable. The aim of our study is to identify drugs associated with aortitis occurrence using a data-mining approach.

Granulocyte colony‐stimulating factor associated arteritis in a patient with castration‐resistant prostate cancer

“…Arteritis may be caused by both infectious or non‐infectious reasons 3,4 . Most non‐infectious arteritis cases were caused by autoimmune diseases (giant cell arteritis and Takayasu arteritis) and were less frequently caused by drugs 5 . G‐CSF is reportedly strongly associated with the occurrence of arteritis 5–7 .…”

“…Most non‐infectious arteritis cases were caused by autoimmune diseases (giant cell arteritis and Takayasu arteritis) and were less frequently caused by drugs 5 . G‐CSF is reportedly strongly associated with the occurrence of arteritis 5–7 . However, arteritis is a rare adverse event of G‐CSF.…”