Antineoplastic and antioxidant activities ofOxystelma esculentumon Swiss albino mice bearing Ehrlich’s ascites carcinoma

Abstract

The present study investigated the antitumor effect and antioxidant role of the methanol extract of Oxystelma esculentum R. Br. (Asclepiadaceae) (MEOE) on tumor growth and the host survival time with mice. The antitumor and antioxidant potential of Oxystelma esculentum were studied against Ehrlich's ascites carcinoma cell line (EAC) treated mice. MEOE was administered at doses of 200 and 400 mg/kg body weight (bw) once a day for 9 days after 24 h of tumor inoculation. Among the treated animals, six animals were sacrificed for biochemical and tumor analysis, and the remaining four groups were kept to study lifespan. On day 10, the parameters of tumor volume, packed cell volume, viable, and non-viable cell count were studied. Hematological and liver biochemical parameters, and antioxidant enzymes such as lipid peroxidation (LPO), glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), etc. were estimated. Decreases in tumor volume, packed cell volume, and viable cell count were observed in MEOEtreated mice when compared to EAC-treated mice. Treatment with MEOE at doses of 200 and 400 mg/kg increased the mean survival time to 29.66 ± 0.71 and 34.33 ± 2.34 days, compared with EAC-treated mice at 19.16 ± 1.13 days. The extract also decreased the body weight of the EAC-bearing mice. Hematological profiles indicated a decrease in white blood cells (WBC), an increase in red blood cells (RBC), and, thereby, Hemoglobin (Hb). MEOE restored all the parameters of hematological profiles to approximately normal. Treatment with MEOE decreased the levels of LPO and increased the levels of GSH, SOD, and CAT. These data indicate the methanol extract of Oxystelma esculentum exhibits significant antitumor activity, which might be due to the antioxidant effects on EAC bearing hosts.

Assessment of the Diuretic Activity of Petroselinum Crispum Aqueous Leaves Extract in Wistar Rats

“…The natriuretic index represented by the N a + /K + ratio was greater than 5 for all the doses of EAPC, suggesting that the extract had a potassium-sparing effect [21]. These results are similar to those obtained with alcoholic extracts of Oxystelma esculentum and Hibiscus sabdariffa promote the elimination of N a + /K + cl − and make urine more alkaline [22].…”

A Complete Review on Oxystelma esculentum R. Br.

“…These data indicate that the methanolic extract of leaves of O. esculentum exhibits significant antitumor activity. [18] Antimicrobial activity…”

Biochemical Effect of Emblica Officinalis on Experimentally Induced Tumor in Female Mice

“…It is the second largest single cause of death in both men and women, claiming over six million lives each year worldwide. In modern medicine, chemotherapy, radiotherapy and surgery are the three major existing modes of treatment (1) . Phyllanthus emblica is a medicinal plant belonging to the Euphorbiaceae family, described in Ayurveda and is a constituent of several poly herbal formulations.…”