Antineoplastic Agents, 162. Zephyranthes candida

Abstract

The Chinese medicinal plant Zephyranthes candida was found to contain a cytostatic constituent. Separation of a n-BuOH extract directed by results of a bioassay employing the P-388 lymphocytic leukemia led to trans-dihydronarciclasine [2] as the principal cytostatic agent with ED50 3.2 X 10(-3) micrograms/ml.

Cytotoxic Alkaloids and a Flavan from the Bulbs of Crinum asiaticum var. japonicum.

“…1) As regards phytochemical studies on this plant, the isolation of phenanthridine alkaloids, fatty acids, sterols and triterpene alcohols have been previously reported. [2][3][4] Alkaloids isolated from the bulbs of the tribe Amaryllidaceae showed various pharmacological and microbiological effects, such as antiviral, 5) antimalarial, 6) cytotoxic [6][7][8][9] and antineoplastic activities, [10][11][12] as well as effects on diseases of the nervous system. 13) An EtOAc-soluble fraction of C. asiaticum var.…”

Phytochemistry and Pharmacology of Genus Zephyranthes

“…In 1984 and 1990 Pettit et al, reported two antineoplastic compounds, pancratistatin from Z. grandiflora and trans-dihydronarciclasine from Z. candida bulbs using the P-388 lymphocytic leukemia bioassay [31,33].…”

Pressurized liquid extraction and anticholinesterase activity-based thin-layer chromatography with bioautography of Amaryllidaceae alkaloids

“…These compounds exhibited several types of pharmacological activities including antiviral [3], antimalarial [4], on central-nervous system (c.n.s.) [5] as well as antineoplastic [6] one. Galanthamine is widely applied in Alzheimer disease, due to the ability of enhancement of cholinergic activity in c.n.s.…”