Antineoplasic Effect of Aqueous Extract of Plectranthus Amboinicus in Ehrlich Ascites Carcinoma

Brandão, Eduardo Miranda; Brandão, Paulo H. D. M.; Souza, Ivone Antônia de; Paiva, Gerson S.; Carvalho, Marcos de C.; Lacerda, Cláudio Moura

doi:10.7150/jca.6730

Cited by 11 publications

(12 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…69,70 For example, a carvacrol-thymol chemotype showed activity on lung cancer cell line A549 71 and an aqueous extract produced antineoplastic effect in ascetic form of Ehrlich carcinoma in mice. 72 In the follow-up assay with cancer cell lines, a statistically significant higher activity (P > .05) of carvacrol with respect to EO-Pa was found. However, these differences are minimal, and thus not relevant in term of efficacy, which suggest that the anticancer properties of EO-Pa could also be attributed to the presence of carvacrol, which can be visualized in Figure 3.…”

Section: Resultsmentioning

confidence: 88%

Pharmacological Assessment of the Carvacrol Chemotype Essential Oil FromPlectranthus amboinicusGrowing in Cuba

Monzote

Scherbakov

Scull

et al. 2020

Natural Product Communications

View full text Add to dashboard Cite

Plant-derived products are employed in various public health practices and have been considered as a major source of medicines. The genus Plectranthus (Lamiaceae) has been widely respected for its nutritional properties, its essential oil, and its therapeutic values. In the present work, the chemical characterization, antimicrobial, antiparasitic, and cytotoxic properties of the essential oil from Plectranthus amboinicus (Lour.) Spreng and its main compound carvacrol were studied. Twenty-one components were identified in the oil by gas chromatography coupled with a mass spectrometric detector. In this oil, carvacrol constitutes the major compound (71%), which represented the more abundant chemotype. The essential oil did not inhibit growth of Escherichia coli, Staphylococcus aureus, Candida albicans, Trypanosoma cruzi, or Leishmania infantum, but displayed activity against Plasmodium falciparum (half-maximal inhibitory concentration [IC50] = 5.9 µg/mL), Trypanosoma brucei (IC50 = 34.9 µg/mL), and Leishmania amazonensis (IC50 = 58.2 µg/mL), and the human tumor-derived cell lines MCF-7 (IC50 = 29.1 µg/mL), MDA-MB-231 (IC50 = 41.5 µg/mL), and 22Rv1 (IC50 = 29.6 µg/mL), but no cytotoxicity was observed against nonmalignant macrophages. The antiproliferative activity of the oil could be attributed to carvacrol. However, this compound showed certain level of cytotoxicity, which suggests unspecific activity. This study provides evidence about antimicrobial and anticancer potential of the essential oil from P. amboinicus against protozoa and neoplastic diseases, particularly as an antimalarial natural product.

show abstract

Section: Resultsmentioning

confidence: 88%

Pharmacological Assessment of the Carvacrol Chemotype Essential Oil FromPlectranthus amboinicusGrowing in Cuba

Monzote

Scherbakov

Scull

et al. 2020

Natural Product Communications

View full text Add to dashboard Cite

show abstract

“…The highlight of the current study is that groups treated with A. carnosus extracts revealed remarkable anti-tumor activity even at low doses such as 30, 50, and 100 mg/kg b. wt. In the past, several studies[ 24 25 26 27 ] have reported good anti-tumor activity in vivo with EAC model although with comparatively higher doses of the anti-cancer agent. Also, previous studies on A. carnosus have revealed the plant to possess strong anti-tumor activity with its ethanolic and petroleum ether extract exhibiting potent anti-tumor activity in vitro against cancer cell lines such as BT-549 (human mammary ductal carcinoma)[ 28 ] and A-549 (human alveolar adenocarcinoma).…”

Section: Discussionmentioning

confidence: 99%

Identity-based high-performance thin layer chromatography fingerprinting profile and tumor inhibitory potential of Anisochilus carnosus (L.f.) wall against ehrlich ascites carcinoma

et al. 2015

View full text Add to dashboard Cite

Context:Anisochilus carnosus (L.f.) wall belonging to the family Lamiaceae is a plant that is widely used in folk medicine for treating eczema, cold, cough, and fever.Objective:In the present study, we explored the anticancer potential of A. carnosus leaves against Ehrlich ascites carcinoma (EAC) and estimated the quantity of luteolin present in various extracts and fractions of A. carnosus by high-performance thin layer chromatography (HPTLC) fingerprinting.Materials and Methods:Various factors such as tumor volume, tumor cell viability, tumor weight, prolongation of lifespan, and hematological parameters were assessed.Result:We observed a significant lowering in tumor volume, tumor weight, and cell viability in EAC-induced mice following intervention with A. carnosus extracts. Also, there was a considerable prolongation of host lifespan and restoration of hematological parameters to almost normal levels with A. carnosus treatment. HPTLC fingerprinting of various extracts and fractions of A. carnosus along with luteolin as the reference standard revealed the occurrence of luteolin in all tested extracts and fractions of A. carnosus with the highest concentration being reported in the ethanol fraction.Conclusion:A. carnosus exhibits potent anti-tumor potential which can most likely be attributed to the occurrence of different phytochemicals such as phytosterols, terpenoids, and flavonoids in the plant. Further studies to isolate compounds from A. carnosus and understand the mechanism of anti-tumor activity would be worthwhile.SUMMARY EAC induced mice that received A. carnosus treatment exhibited significant reduction in tumor volume, tumor weight and tumor cell viability. Their life span was considerably prolonged. We detected luteolin in A. carnosus aqueous and ethanol extract using HPTLC. Hence, anticancer activity of A. carnosus can be partly attributed to the presence of luteolin.

show abstract

“…In basic research, the effectiveness of essential oils with other plant essential oils for possible be used as mosquito repellents [4,5]. Juice from its leaves is commonly used for illnesses including liver and renal conditions, to treat inflammatory diseases or swelling symptoms and cancer [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Assessment of Antioxidant activity, Antimicrobial, and cytotoxicity of ultrasound-assisted acetone extracts of Plectranthus amboinicus

Ye¹,

Deng²,

Xia³

et al. 2020

Preprint

View full text Add to dashboard Cite

The bacteriostatic, antioxidant and cytotoxic activities of a series of Plectranthus amboinicus were determined. The bacteriostatic performance of Plectranthus amboinicus was evaluated by evaluating the bacteriostatic effect of 10 mg/mL on Gram-positive and Gram-negative bacteria and yeasts. The antioxidant activity of Plectranthus amboinicus was analyzed by DPPH method, and the results showed that it had strong ability of scavenging free radicals. In addition, the general toxicity of Plectranthus amboinicus was evaluated in the Artemia model, and the results showed that the toxicity value was not significant. In turn, through the evaluation of cell viability, all extracts were found to be non-toxic in the concentration range of 0-10 μg/mL in Vero-E6 and 786-O cells. The tested samples have encouraging antibacterial and antioxidant properties, which represents the plant's role in designing new drugs to treat infectious diseases.

show abstract

Antineoplasic Effect of Aqueous Extract of Plectranthus Amboinicus in Ehrlich Ascites Carcinoma

Cited by 11 publications

References 5 publications

Pharmacological Assessment of the Carvacrol Chemotype Essential Oil FromPlectranthus amboinicusGrowing in Cuba

Pharmacological Assessment of the Carvacrol Chemotype Essential Oil FromPlectranthus amboinicusGrowing in Cuba

Identity-based high-performance thin layer chromatography fingerprinting profile and tumor inhibitory potential of Anisochilus carnosus (L.f.) wall against ehrlich ascites carcinoma

In Vitro Assessment of Antioxidant activity, Antimicrobial, and cytotoxicity of ultrasound-assisted acetone extracts of Plectranthus amboinicus

Contact Info

Product

Resources

About