Antimycobacterial triterpenoids from Lantana hispida (Verbenaceae)

Jiménez-Arellanes, María Adelina; Meckes, Mariana; Torres, Javier; Luna-Herrera, Julieta

doi:10.1016/j.jep.2006.11.033

Cited by 77 publications

(61 citation statements)

References 17 publications

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“…Oleanenoic acid (11) showed a MIC of 25 µg/mL against the streptomycin-and isoniazidresistant strains of M. tuberculosis H37Rv and 50 µg/mL against rifampin-and ethambutol-resistant variants. The compounds 5 and 6 were also active at 50 µg/mL against all the drug-resistant variants of M. tuberculosis H37Rv tested (Jiménez-Arellanes et al, 2007). The compounds lantanoside (75), linaroside (76) and isolated from L. camara L. were also effective against strains of M. tuberculosis, both with a MIC of 6.25 µg/mL (Begum et al, 2000).…”

Section: Antibacterial Antifungal Activitymentioning

confidence: 95%

“…Lantana hispida Kunth is a widely distributed Mexican ornamental plant (Jiménez-Arellanes et al, 2007). Lantana cujabensis Schauer is a shrub that grows at an elevation of up to 1000 m and is found in both the Amazon and Andean forests of South America (Brako & Zarucchi, 1993).…”

Section: Occurrence and Distributionmentioning

confidence: 99%

“…hispida Kunth traditionally is used in Mexico to treat tuberculosis, bronchitis, cough, cold, asthma, stomach ailments, kidney pain and diarrhea (Jiménez-Arellanes et al, 2007). In Bolivia, leaves of L. cujabensis Schauer are crushed between fingers and sniffed to treat head colds (Okunade & Lewis, 2004).…”

Section: Traditional Applicationmentioning

confidence: 99%

“…The modulatory evaluation of a mixture of the compounds 22β-dimethylacryloyloxy-3β-hydroxyolean-12-en-28-oic acid (6) and oleanenoic acid (11) of L. hispida Kunth against M. tuberculosis H37Rv and drug-resistant variants of H37Rv strains showed MIC values ranging from 50 to 100 µg/mL, suggesting that a synergistic effect did not occur (Jiménez-Arellanes et al, 2007).…”

Section: Modulatory Activitymentioning

confidence: 99%

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Genus Lantana: chemical aspects and biological activities

Sousa¹,

Costa²

2012

Rev. bras. farmacogn.

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Species of the genus Lantana, belonging to the family Verbenaceae, is among the various species studied scientifically. These species are mainly native to the tropical and subtropical regions of the Americas. Currently, they are present in various countries, where they are often grown as ornamental plants. For decades, species of Lantana have been of great interest for phytochemical, biological and pharmacological studies, which have been recently intensified. The components isolated from different species of Lantana cited in the literature constitute the focus of this review. Information ethnopharmacology of Lantana, as well as the activities of their different phytochemicals are discussed. In this review, it was observed that the genus Lantana has been widely studied in relation to its phytochemical components and terpenoids, flavonoids and phenylpropanoids are the more common secondary metabolites in Lantana. All these aspects, considered in this review, allow an evaluation of the ethnopharmacological potential of Lantana for the utilization of the large biomass of these plants.

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Section: Antibacterial Antifungal Activitymentioning

confidence: 95%

Section: Occurrence and Distributionmentioning

confidence: 99%

Section: Traditional Applicationmentioning

confidence: 99%

Section: Modulatory Activitymentioning

confidence: 99%

See 2 more Smart Citations

Genus Lantana: chemical aspects and biological activities

Sousa¹,

Costa²

2012

Rev. bras. farmacogn.

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“…This compound and its derivatives have been known to exhibit a variety of biological activities, including anti-inflammatory [5], anti-HIV [9], anti-angiogenesis [18], anti-mutagenic [2], and gastroprotective and ulcer-healing [16] activities. In addition, oleanolic acid was suggested to display an antibacterial or bactericidal effect against different bacteria including Mycobacterium tuberculosis [8], Streptococcus pneumoniae and methicillin-resistant Staphylococcus aureus (MRSA) [6].…”

Section: Introductionmentioning

confidence: 99%

Identification of Inhibitory Effect on Streptococcus mutans by Oleanolic Acid

Yoon¹,

Choi

2010

Journal of Life Science

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Among endogenous oral microflora, Streptococcus mutans plays a critical role in dental plaque formation, which mainly contributes to the development of caries and periodontal disease. Phytochemicals are plant-derived chemical compounds that have been studied as beneficial nutrients to human health. The purpose of this study was to determine the effects of phytochemicals against S. mutans. Among them, oleanolic acid (OA) and 5-(hydroxymethyl)-2-furfural (HF) from Thomson seedless raisins were tested for anti-microbial effects against various clinically important bacteria. OA inhibited the growth of Gram-positive bacteria, but not Gram-negative bacteria. However, HF did not display any antibacterial effect against any of the strains tested. OA also exhibited inhibitory effects in surface adherence and biofilm formation of S. mutans. The results suggest that OA can be utilized as a potential anti-plaque and anti-caries agent by controlling the physiological characteristics of S. mutans on teeth.

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Antitubercular potential of plants: A brief account of some important molecules

Negi

Kumar

Luqman

et al. 2009

Medicinal Research Reviews

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Mycobacterium tuberculosis is the most lethal pathogen causing tuberculosis in human. After the discovery of antitubercular drugs pyrazinamide, rifampicin, isoniazid, streptomycin, and ethambutol (PRISE), the disease was controlled for a limited period. However, over the course of their usage, the pathogen acquired resistance and evolved into multi-drug resistant, single-drug resistant, and extensive drug resistant forms. A good number of plant secondary metabolites are reported to have antitubercular activity comparable to the existing antitubercular drugs or sometimes even better in potency. A well-defined strategy is required to exploit these phytomolecules as antitubercular drugs. This review gives concise up-to-date information regarding the chemistry and pharmacology of plant-based leads and some insight into their structure-activity relationship.

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Antimycobacterial triterpenoids from Lantana hispida (Verbenaceae)

Cited by 77 publications

References 17 publications

Genus Lantana: chemical aspects and biological activities

Genus Lantana: chemical aspects and biological activities

Identification of Inhibitory Effect on Streptococcus mutans by Oleanolic Acid

Antitubercular potential of plants: A brief account of some important molecules

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