Antimycobacterial pyridine carboxamides: From design to in vivo activity

New nitazoxanide derivatives: design, synthesis, biological evaluation, and molecular docking studies as antibacterial and antimycobacterial agents

“…45 To increase its metabolic stability and activity, 4-ASA has its carboxylic and 4-amino groups undergone structural modification strategies. [46][47][48][49][50] One of these strategies is to employ 4-azidosalicylic acid as a precursor for 4-ASA because it is anticipated that mycobacteria will bioreductively activate it. 50 The azido group is also an active moiety in some biologically active compounds such as anti-TB 51 (compound I; Fig.…”