Antimycobacterial Matricaria Esters and Lactones from Astereae Species

Abstract

Six matricaria esters (MEs) and two matricaria lactones (MLs), isolated from members of the tribe Astereae (Asteraceae), were tested against Mycobacterium tuberculosis and M. avium, using a radiorespirometric bioassay. (2Z,8Z)-ME and (2E-8Z)-ME gave minimum inhibitory concentrations (MICs) of 50 micrograms ml-1 against M. tuberculosis and respective MICs of 25 and 50 micrograms ml-1 against M. avium. The (4Z,8Z)-ML, (2Z)-8-dehydro-ME and (2Z,8Z)-10-angeloyloxy-(2Z,8Z)-ME showed respective MICs of 12.5, 25, 25 micrograms ml-1 against M. tuberculosis and MICs of 50, 25, 25 micrograms ml-1 against M. avium, respectively. The MICs of (2Z,8Z)-10-tigloyloxy-ME and (2E,8Z)-10-angeloyloxy-ME and (4E,8Z)-ML ranged from 50 to > 100 micrograms ml-1 against both pathogenic mycobacteria.

Antimicrobial and cytotoxic activities screening of some Brazilian medicinal plants used in Governador Valadares district

“…On the other hand, species without ethnomedicinal report about antibiotic activity inhibited bacteria growth. Curiously, Chamomilla tinctoria, which inhibit S. aureus growth, was not nominated as an antibiotic remedy by "raizeiros", despite several reports at literature present extracts from Chamomilla species as an antimicrobial agent (Benetti, Manganelli, 1985;Lu et al, 1998;Stamatis et al, 2003;Mazokopakis et al, 2005). Bara and Vanetti (1998) tested extracts from A. lappa and P. major against S. aureus and those extracts did not present activity.…”

A Review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.)

“…In this experiment, the highest concentration of chamomile oil used (3000 ppm) exhibited the highest inhibition against these microorganisms (91-95%); however, the oils of thyme and cinnamon were more effective at lower concentrations (≤500 ppm). Esters and lactones from German chamomile showed activity against Mycobacterium tuberculosis and M. avium (Lu et al, 1998), and an ethanol extract of German chamomile inhibited the growth of both herpes and polio virus (Aggag and Yousef, 1972;Vilagines et al, 1985). Al-Ismail and Talal (2003) reported that, in general, aqueous extracts of chamomile were more effective against molds and yeast, while alcohol extracts showed higher activities against bacteria.…”

Chemical variability of Conyza sumatrensis and Microglossa pyrifolia from Côte d'Ivoire

“…The mono-and sesquiterpenes that dominated the leaf and flower oils were present in low contents; only thymol reached 2.1%. Although (Z)-lachnophyllum acid methyl ester, one of the polyacetylene compounds of the essential oils [20][21][22] and extracts [23][24][25] of several Asteraceae species, was present in the investigated samples (CL0, CL1, CL2; 1.1-12.0%), the composition of the Ivorian leaf oil from Conyza sumatrensis differed from that of the Brazilian leaf oil previously reported and characterized by the preeminence of (Z)-lachnophyllum acid methyl ester (43.7%) and limonene (22.9%).…”