Antimycobacterial Compounds From Nasturtium Officinale

Abstract

Background: Nasturtium officinale is a plant used in Mexican traditional medicine to treat respiratory infections such as tuberculosis. In
 previous studies, it was found that the chloroform extract of the aerial parts of N. officinale showed good activity against one sensitive and four
 drug-resistant Mycobacterium tuberculosis H37Rv strains. Therefore, the present research was focused on the fractionation and identification of
 the antimycobacterial principles of this species.
 Material and Methods: The chloroform extract was prepared and fractionated by column chromatography using silica gel and gradient of
 chloroform/methanol, yielding 14 fractions. Each fraction was analyzed by thin-layer chlromatography under UV light. The obtained fractions
 were further tested against Mycobacterium tuberculosis H37Rv strain using Alamar blue microassay.
 Results: Of the 14 fractions assayed, only fractions 3 to 5 showed good inhibitory activity against M. tuberculosis H37Rv. The chemical
 composition of three fractions by GC-MS led to the identification of E-phytol as the most abundant and common component.
 Conclusion: Antimycobacterial properties of the three active fractions were attributed to E-phytol and palmitic acid.

(R)-8-Methylsulfinyloctyl isothiocyanate from Nasturtium officinale inhibits LPS-induced immunoinflammatory responses in mouse peritoneal macrophages: chemical synthesis and molecular signaling pathways involved

“…Watercress as a medicinal plant has its origins in the ancient and traditional medicines of Iran, where it is used to treat pathologies such as renal colic, hypertension and hyperglycemia. 1 In the literature, the different biological activities of this plant extract are described, such as cardioprotective, 2,3 hypolipidemic, 4 anticancer, 5–9 antioxidant, 2,10–15 anti-inflammatory, 10,12,15–17 antidiabetic, 18 antibacterial, 19,20 antiallergic, 21 and antipsoriatic activities, 22 as well as its effects on the reproductive system. 23…”