Antimycobacterial and antitumor activities of Palladium(II) complexes containing isonicotinamide (isn): X-ray structure of trans-[Pd(N3)2(isn)2]

Souza, Rodrigo Othávio de Assunção e; Stevanato, Alessandra; Treu-Filho, Oswaldo; Netto, Adelino Vieira de Godoy; Mauro, Antônio Eduardo; Castellano, Eduardo E.; Carlos, Iracilda Zeppone; Pavan, Fernando Rogério; Leite, Clarice Queico Fujimura

doi:10.1016/j.ejmech.2010.07.057

Cited by 53 publications

(17 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thiosemicarbazones (TSCs) are of great interest both in chemistry and biology, especially due to their antiparasital [11], antitumor [12][13][14] and antibacterial activities [15]. Moreover, the biological properties of the TSCs are often referred to their complex formation since it can increase the biological activity by forming chelates with metal ions [12,16,17].…”

Section: Introductionmentioning

confidence: 99%

Manganese(II) complexes with thiosemicarbazones as potential anti-Mycobacterium tuberculosis agents

Oliveira

Maia

Souza

et al. 2014

Journal of Inorganic Biochemistry

Self Cite

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Manganese(II) complexes with thiosemicarbazones as potential anti-Mycobacterium tuberculosis agents

Oliveira

Maia

Souza

et al. 2014

Journal of Inorganic Biochemistry

Self Cite

View full text Add to dashboard Cite

“…In this context, several research groups have explored the potential therapeutic applications of cyclopalladated complexes (34, 41–46). Regarding kinetoplastid diseases, it has been shown that cyclopalladated complexes were efficacious in reducing the parasite load in an in vivo leishmanial cutaneous model (18) and exhibited trypanocidal potential for Chagas disease treatment (17).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of a Binuclear Cyclopalladated Compound Therapy for Cutaneous Leishmaniasis in the Murine Model of Infection with Leishmania amazonensis and Its Inhibitory Effect on Topoisomerase 1B

Velásquez

Ribeiro

Venn

et al. 2017

Antimicrob Agents Chemother

View full text Add to dashboard Cite

Leishmaniasis is a disease found throughout the (sub)tropical parts of the world caused by protozoan parasites of the Leishmania genus. Despite the numerous problems associated with existing treatments, pharmaceutical companies continue to neglect the development of better ones. The high toxicity of current drugs combined with emerging resistance makes the discovery of new therapeutic alternatives urgent. We report here the evaluation of a binuclear cyclopalladated complex containing Pd(II) and N,N′-dimethylbenzylamine (Hdmba) against Leishmania amazonensis. The compound [Pd(dmba)(μ-N3)]2 (CP2) inhibits promastigote growth (50% inhibitory concentration [IC50] = 13.2 ± 0.7 μM) and decreases the proliferation of intracellular amastigotes in in vitro incubated macrophages (IC50 = 10.2 ± 2.2 μM) without a cytotoxic effect when tested against peritoneal macrophages (50% cytotoxic concentration = 506.0 ± 10.7 μM). In addition, CP2 was also active against T. cruzi intracellular amastigotes (IC50 = 2.3 ± 0.5 μM, selective index = 225), an indication of its potential for use in Chagas disease therapy. In vivo assays using L. amazonensis-infected BALB/c showed an 80% reduction in parasite load compared to infected and nontreated animals. Also, compared to amphotericin B treatment, CP2 did not show any side effects, which was corroborated by the analysis of plasma levels of different hepatic and renal biomarkers. Furthermore, CP2 was able to inhibit Leishmania donovani topoisomerase 1B (Ldtopo1B), a potentially important target in this parasite. (This study has been registered at ClinicalTrials.gov under identifier NCT02169141.)

show abstract

“…μM[39]. Despite the fact that in vitro activity of [Pd(C-bzan)(SCN)(dppp)] is comparable or superior to those found for some commonly used anti-TB drugs(gentamicin, 4.19-8.38 μM; tobramycin, 8.56 17.11 μM; clarithromycin, 10.70-21.40 μM; cycloserine, 122.4-489.7 μM)…”

mentioning

confidence: 93%

Structure and antimycobacterial activity of the novel organometallic [Pd(C-bzan)(SCN)(dppp)] compound

Ferreira

Stevanato

Santana³

et al. 2012

Inorganic Chemistry Communications

Self Cite

View full text Add to dashboard Cite

Antimycobacterial and antitumor activities of Palladium(II) complexes containing isonicotinamide (isn): X-ray structure of trans-[Pd(N3)2(isn)2]

Cited by 53 publications

References 56 publications

Manganese(II) complexes with thiosemicarbazones as potential anti-Mycobacterium tuberculosis agents

Manganese(II) complexes with thiosemicarbazones as potential anti-Mycobacterium tuberculosis agents

Efficacy of a Binuclear Cyclopalladated Compound Therapy for Cutaneous Leishmaniasis in the Murine Model of Infection with Leishmania amazonensis and Its Inhibitory Effect on Topoisomerase 1B

Structure and antimycobacterial activity of the novel organometallic [Pd(C-bzan)(SCN)(dppp)] compound

Contact Info

Product

Resources

About