Antimycobacterial activity of methdilazine (Md), an antimicrobic phenothiazine

Chakrabarty, Anindita; Bhattacharya, Chandrima; Dastidar, Sujata G.

doi:10.1111/j.1699-0463.1993.tb00133.x

Cited by 22 publications

(10 citation statements)

References 6 publications

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“…In addition to the varied MIC ranges, the spectrum of antibacterial activity was somehow variable in the previous studies where the tested phenothiazines were generally potent against the Gram-positive microorganisms; however their effect against the Gramnegative ones was either comparable to that against the Grampositive ones or inferior to it. Moreover, some phenothiazine antihistaminics showed certain anti-tuberculosis activity (13,17,36).…”

Section: Introductionmentioning

confidence: 99%

In vitro antibacterial activity of some antihistaminics belonging to different groups against multi-drug resistant clinical isolates

El-Nakeeb¹,

Abou-Shleib²,

Khalil³

et al. 2011

Braz. J. Microbiol.

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Antihistaminics are widely used for various indications during microbial infection. Hence, this paper investigates the antimicrobial activities of 10 antihistaminics belonging to both old and new generations using multiresistant Gram-positive and Gram-negative clinical isolates. The bacteriostatic activity of antihistaminics was investigated by determining their MIC both by broth and agar dilution techniques against 29 bacterial strains. Azelastine, cyproheptadine, mequitazine and promethazine were the most active among the tested drugs. Diphenhydramine and cetirizine possessed weaker activity whereas doxylamine, fexofenadine and loratadine were inactive even at the highest tested concentration (1 mg/ml). The MIC of meclozine could not be determined as it precipitated with the used culture media. The MBC values of antihistaminics were almost identical to the corresponding MIC values. The bactericidal activity of antihistaminics was also studied by the viable count technique in sterile saline solution. Evident killing effects were exerted by mequitazine, meclozine, azelastine and cyproheptadine. Moreover, the dynamics of bactericidal activity of azelastine were studied by the viable count technique in nutrient broth. This activity was found to be concentration-dependant. This effect was reduced on increasing the inoculum size while it was increased on raising the pH. The post-antimicrobial effect of 100 g/ml azelastine was also determined and reached up to 3.36 h.

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Section: Introductionmentioning

confidence: 99%

In vitro antibacterial activity of some antihistaminics belonging to different groups against multi-drug resistant clinical isolates

El-Nakeeb¹,

Abou-Shleib²,

Khalil³

et al. 2011

Braz. J. Microbiol.

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“…Such compounds having antimicrobial properties in addition to their predesignated pharmacological actions have been christened 'non-antibiotics' [20]. Some of these compounds have also been recognised for their antitubercular function [21][22][23][24]. From all these studies, it is apparent that the phenothiazines and thioxanthenes, both possessing three benzene rings, are often endowed with potent antimicrobial action.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial potentiality of the thioxanthene flupenthixol through extensive in vitro and in vivo experiments

Jeyaseeli

Gupta

Kumar

et al. 2006

International Journal of Antimicrobial Agents

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“…Soon after chlorpromazine was widely used, psychotic patients presenting with cavitary infections of M. tuberculosis were cleared of this infection (Kaminska 1967). More recently, the phenothiazine methdilazine was shown to cure mice of experimental infections of tuberculosis (Chakrabarty et al . 1993).…”

Section: Introductionmentioning

confidence: 99%

Phenothiazines: potential alternatives for the management of antibiotic resistant infections of tuberculosis and malaria in developing countries

Amaral

Viveiros

Kristiansen

2001

Tropical Med Int Health

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SummaryThe in vitro and in vivo activity of phenothiazines against antibiotic susceptible and antibiotic resistant Mycobacterium tuberculosis and malaria-causing Plasmodia is reviewed. Given the facts that pulmonary tuberculosis and malaria are the major causes of death in developing countries, that both of these infections continue to escalate in their resistance to antibiotics, that the cost for the management of these infections is beyond that afforded by most developing nations, and lastly, that new and effective agents are not forthcoming from the pharmaceutical industry, the scienti®c rationale for the potential use of select phenothiazines for the management of these infections is presented.keywords phenothiazines, antimicrobial activity, tuberculosis, malaria correspondence Professor Leonard Amaral,

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Antimycobacterial activity of methdilazine (Md), an antimicrobic phenothiazine

Cited by 22 publications

References 6 publications

In vitro antibacterial activity of some antihistaminics belonging to different groups against multi-drug resistant clinical isolates

In vitro antibacterial activity of some antihistaminics belonging to different groups against multi-drug resistant clinical isolates

Antimicrobial potentiality of the thioxanthene flupenthixol through extensive in vitro and in vivo experiments

Phenothiazines: potential alternatives for the management of antibiotic resistant infections of tuberculosis and malaria in developing countries

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