Antimycobacterial Activity and Chemical Characterization of the Essential Oils from Reproductive Organs of Piper lhotzkyanum Kunth (Piperaceae)

Costa-Oliveira, Claudete da; Ramos, Ygor Jessé; Queiroz, George Azevedo de; Guimarães, Elsie Franklin; Heggdorne-Araujo, Marlon; Lassounskaia, Elena; Muzitano, Michelle Frazão; Marcelino, Diego S.; Moreira, Davyson de Lima

doi:10.21577/1984-6835.20210066

Cited by 3 publications

(2 citation statements)

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“…As mentioned earlier, the sensitivity and susceptibility of this EO to light incidence can result in the conversion of α-zingiberene into bicyclogermacrene in high light exposure. This can have implications not only for the quality of the EO but also for possible different biological and pharmacological applications that may occur [48].…”

Section: Discussionmentioning

confidence: 99%

Chemical Diversity and Redox Values Change as a Function of Temporal Variations of the Essential Oil of a Tropical Forest Shrub

et al. 2023

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This study investigated the chemical phenotypical variability of Piper lhotzkyanum Kunth (Piperaceae), a shrub found in Brazilian tropical forests, over time (different periods of the day and seasons) and under natural conditions. For this, essential oils (EOs) from the leaves were collected in different seasons and times of the day and analyzed by gas chromatography coupled with mass spectrometry, and gas chromatography coupled with a flame ionization detector. The indices were applied to evaluate the chemical diversity as well as the dynamics of redox of the mixtures. The results showed that the EOs were dominated by non-oxygenated sesquiterpenes, with β-elemene, E-caryophyllene, and α-zingiberene being the main compounds identified in all collections. Temporal and seasonal analyses revealed important fluctuations in the chemical composition, redox, and chemical diversity indices of the species. A correlation between climatic factors and the variation in redox and chemical diversity was observed, highlighting the chemical phenotypic plasticity P. lhotzkyanum. This study resolves a previously unanswered question by confirming that natural light does not produce interconversion of major compounds. The adaptation capacity of this species to the environmental changes suggests new cultivation strategies to maximize the quality of EO and promote a more sustainable future in partnership with nature.

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Section: Discussionmentioning

confidence: 99%

Chemical Diversity and Redox Values Change as a Function of Temporal Variations of the Essential Oil of a Tropical Forest Shrub

et al. 2023

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“…Several biological studies have documented the antimycobacterial efficacy of essential oils derived from different species of the Piper genus, showcasing moderate to good activity against M. tuberculosis. Specifically, essential oils from the infructescences and inflorescences of Piper lhotzkyanum Kunth exhibited minimum inhibitory concentrations (MICs) of 76 µg/mL and 128 µg/mL, respectively [52]. Similarly, leaf oils from Piper cernuum Vell., Piper diospyrifolium Kunth, and Piper rivinoides Kunth demonstrated MIC values of 125 µg/mL, while Piper mosenii C.DC.…”

Section: Chemical Composition Analysis Of the Bioactive Partitionmentioning

confidence: 99%

UHPLC-HRMS/MS Chemical Fingerprinting of the Bioactive Partition from Cultivated Piper aduncum L.

de Luna,

Fagundes,

Ramos

et al. 2024

Molecules

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Piper aduncum L. is widely distributed in tropical regions and the ethnobotanical uses of this species encompass medicinal applications for the treatment of respiratory, antimicrobial, and gynecological diseases. Chemical studies reveal a diverse array of secondary metabolites, including terpenes, flavonoids, and prenylated compounds. Extracts from P. aduncum have shown antibacterial, antifungal, and larvicidal activities. Our study explores the activity of extracts and partitions against Mycobacterium tuberculosis H37Rv, as well as the chemical diversity of the bioactive partition. This marks the first investigation of the bioactive partition of P. aduncum from agroecological cultivation. The ethyl acetate partition from the ethanolic leaf extract (PAEPL) was found to be the most active. PAEPL was subjected to column chromatography using Sephadex LH-20 and the obtained fractions were analyzed using UHPLC-HRMS/MS. The MS/MS data from the fractions were submitted to the online GNPS platform for the generation of the molecular network, which displayed 1714 nodes and 167 clusters. Compounds were identified via manual inspection and different libraries, allowing the annotation of 83 compounds, including flavonoids, benzoic acid derivatives, glycosides, free fatty acids, and glycerol-esterified fatty acids. This study provides the first chemical fingerprint of an antimycobacterial sample from P. aduncum cultivated in an agroecological system.

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Chemical composition and antimycobacterial, anti- Malassezia furfur and cytotoxic activities of essential oils from Callistemon viminalis (Sol. ex Gaertn.) G. Don leaves and flowers

Silva,

Fernandes,

Silva

et al. 2024

Natural Product Research

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Antimycobacterial Activity and Chemical Characterization of the Essential Oils from Reproductive Organs of Piper lhotzkyanum Kunth (Piperaceae)

Cited by 3 publications

References 0 publications

Chemical Diversity and Redox Values Change as a Function of Temporal Variations of the Essential Oil of a Tropical Forest Shrub

Chemical Diversity and Redox Values Change as a Function of Temporal Variations of the Essential Oil of a Tropical Forest Shrub

UHPLC-HRMS/MS Chemical Fingerprinting of the Bioactive Partition from Cultivated Piper aduncum L.

Chemical composition and antimycobacterial, anti- Malassezia furfur and cytotoxic activities of essential oils from Callistemon viminalis (Sol. ex Gaertn.) G. Don leaves and flowers

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