Antimycins A19 and A20, two new antimycins produced by marine actinomycete Streptomyces antibioticus H74-18

Xu, Lin-Ya; Quan, Xue-Sheng; Wang, Chen; Sheng, Hui‐Fang; Zhou, Guang‐Xiong; Lin, Bei; Jiang, Ren‐Wang; Yao, Xin‐Sheng

doi:10.1038/ja.2011.65

Cited by 30 publications

(15 citation statements)

References 7 publications

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“…Antimycin B1 ( 39 ) was inactive against the bacteria Bacillus subtilis , Staphyloccocus aureus and Loktanella hongkongensis , but antimycin B2 ( 40 ) showed antibacterial activities against S. aureus and L. hongkongensis with MIC values of 32.0 and 8.0 μg/mL respectively. Two new compounds antimycin A19 ( 41 ) and A20 ( 42 ) were isolated from Streptomyces antibioticus H74-18 in the bottom soil of the mangrove zone in the south China sea and these compounds showed antifungal activities against Candida albicans with MIC of about 5–10 μg/mL [59]. In 2011 total synthesis of the (+)-antimycin A family was reported and the nine-membered dilactone ring was obtained successfully by lactonization of a 2-pyridinethiol ester bearing a TIPS group on the 8-OH [60].…”

Section: Natural Products Produced By Mangrove Actinomycetesmentioning

confidence: 99%

Natural Products from Mangrove Actinomycetes

et al. 2014

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Mangroves are woody plants located in tropical and subtropical intertidal coastal regions. The mangrove ecosystem is becoming a hot spot for natural product discovery and bioactivity survey. Diverse mangrove actinomycetes as promising and productive sources are worth being explored and uncovered. At the time of writing, we report 73 novel compounds and 49 known compounds isolated from mangrove actinomycetes including alkaloids, benzene derivatives, cyclopentenone derivatives, dilactones, macrolides, 2-pyranones and sesquiterpenes. Attractive structures such as salinosporamides, xiamycins and novel indolocarbazoles are highlighted. Many exciting compounds have been proven as potential new antibiotics, antitumor and antiviral agents, anti-fibrotic agents and antioxidants. Furthermore, some of their biosynthetic pathways have also been revealed. This review is an attempt to consolidate and summarize the past and the latest studies on mangrove actinomycetes natural product discovery and to draw attention to their immense potential as novel and bioactive compounds for marine drugs discovery.

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Section: Natural Products Produced By Mangrove Actinomycetesmentioning

confidence: 99%

Natural Products from Mangrove Actinomycetes

et al. 2014

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“…Antimycins A 19 and A 20 (antimycin antibiotics), which inhibited C. albicans with an MIC of about 5–10 µg/ml, were isolated from a culture broth of marine actinomycete Streptomyces antibioticus H74-18 (Xu et al 2011a). …”

Section: Antifungal Productsmentioning

confidence: 99%

Antifungal and antiviral products of marine organisms

Cheung

Wong

Pan

et al. 2014

Appl Microbiol Biotechnol

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Marine organisms including bacteria, fungi, algae, sponges, echinoderms, mollusks, and cephalochordates produce a variety of products with antifungal activity including bacterial chitinases, lipopeptides, and lactones; fungal (−)-sclerotiorin and peptaibols, purpurides B and C, berkedrimane B and purpuride; algal gambieric acids A and B, phlorotannins; 3,5-dibromo-2-(3,5-dibromo-2-methoxyphenoxy)phenol, spongistatin 1, eurysterols A and B, nortetillapyrone, bromotyrosine alkaloids, bis-indole alkaloid, ageloxime B and (−)-ageloxime D, haliscosamine, hamigeran G, hippolachnin A from sponges; echinoderm triterpene glycosides and alkene sulfates; molluscan kahalalide F and a 1485-Da peptide with a sequence SRSELIVHQR; and cepalochordate chitotriosidase and a 5026.9-Da antifungal peptide. The antiviral compounds from marine organisms include bacterial polysaccharide and furan-2-yl acetate; fungal macrolide, purpurester A, purpurquinone B, isoindolone derivatives, alterporriol Q, tetrahydroaltersolanol C and asperterrestide A, algal diterpenes, xylogalactofucan, alginic acid, glycolipid sulfoquinovosyldiacylglycerol, sulfated polysaccharide p-KG03, meroditerpenoids, methyl ester derivative of vatomaric acid, lectins, polysaccharides, tannins, cnidarian zoanthoxanthin alkaloids, norditerpenoid and capilloquinol; crustacean antilipopolysaccharide factors, molluscan hemocyanin; echinoderm triterpenoid glycosides; tunicate didemnin B, tamandarins A and B and; tilapia hepcidin 1–5 (TH 1–5), seabream SauMx1, SauMx2, and SauMx3, and orange-spotted grouper β-defensin. Although the mechanisms of antifungal and antiviral activities of only some of the afore-mentioned compounds have been elucidated, the possibility to use those known to have distinctly different mechanisms, good bioavailability, and minimal toxicity in combination therapy remains to be investigated. It is also worthwhile to test the marine antimicrobials for possible synergism with existing drugs. The prospects of employing them in clinical practice are promising in view of the wealth of these compounds from marine organisms. The compounds may also be used in agriculture and the food industry.

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“…Molecular studies showed that these compounds could inhibit the mitochondrial electron transport chain between cytochromes b and c [9]. To date, 20 antimycin A compounds have been reported [10]. A recent report analyzing the biosynthetic gene clusters of antimycin A from Streptomyces sp.…”

Section: Introductionmentioning

confidence: 99%

Two Antimycin A Analogues from Marine-Derived Actinomycete Streptomyces lusitanus

et al. 2012

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Two new antimycin A analogues, antimycin B1 and B2 (1–2), were isolated from a spent broth of a marine-derived bacterium, Streptomyces lusitanus. The structures of 1 and 2 were established on the basis of spectroscopic analyses and chemical methods. The isolated compounds were tested for their anti-bacterial potency. Compound 1 was found to be inactive against the bacteria Bacillus subtilis, Staphyloccocus aureus, and Loktanella hongkongensis. Compound 2 showed antibacterial activities against S. aureus and L. hongkongensis with MIC values of 32.0 and 8.0 μg/mL, respectively.

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Antimycins A19 and A20, two new antimycins produced by marine actinomycete Streptomyces antibioticus H74-18

Cited by 30 publications

References 7 publications

Natural Products from Mangrove Actinomycetes

Natural Products from Mangrove Actinomycetes

Antifungal and antiviral products of marine organisms

Two Antimycin A Analogues from Marine-Derived Actinomycete Streptomyces lusitanus

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