Antimutagenicity of components of dairy products

Abdelali, Hasnaà; Cassand, Pierrette; Soussotte, Valérie; Koch-Bocabeille, Brigitte; Narbonne, Jean‐François

doi:10.1016/0027-5107(95)00059-r

Cited by 36 publications

(12 citation statements)

References 24 publications

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“…In a pathogenic context, in vitro and in vivo studies showed that several LAB present in fermented milks may have an inhibitory effect on the development of precancerous lesions and tumours in animal models 103 . In Ames’ test, B. animalis DN‐173 010 has been shown to have an inhibitory effect towards indirect mutagenic agents in vitro 109–111 . In vivo , in rats, several studies have confirmed the protective effects of milk, fermented milk and various LAB with respect to chemically‐induced colonic carcinogenesis 109, 112, 113 .…”

Section: Physiological Effects and Clinical Benefits Of Bifidobacteriamentioning

confidence: 96%

Review article: bifidobacteria as probiotic agents – physiological effects and clinical benefits

Picard

Fioramonti²,

François

et al. 2005

Aliment Pharmacol Ther

526

337

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Summary Bifidobacteria, naturally present in the dominant colonic microbiota, represent up to 25% of the cultivable faecal bacteria in adults and 80% in infants. As probiotic agents, bifidobacteria have been studied for their efficacy in the prevention and treatment of a broad spectrum of animal and/or human gastrointestinal disorders, such as colonic transit disorders, intestinal infections, and colonic adenomas and cancer. The aim of this review is to focus on the gastrointestinal effects of bifidobacteria as probiotic agents in animal models and man. The traditional use of bifidobacteria in fermented dairy products and the GRAS (‘Generally Recognised As Safe’) status of certain strains attest to their safety. Some strains, especially Bifidobacterium animalis strain DN‐173 010 which has long been used in fermented dairy products, show high gastrointestinal survival capacity and exhibit probiotic properties in the colon. Bifidobacteria are able to prevent or alleviate infectious diarrhoea through their effects on the immune system and resistance to colonization by pathogens. There is some experimental evidence that certain bifidobacteria may actually protect the host from carcinogenic activity of intestinal flora. Bifidobacteria may exert protective intestinal actions through various mechanisms, and represent promising advances in the fields of prophylaxis and therapy.

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Section: Physiological Effects and Clinical Benefits Of Bifidobacteriamentioning

confidence: 96%

Review article: bifidobacteria as probiotic agents – physiological effects and clinical benefits

Picard

Fioramonti²,

François

et al. 2005

Aliment Pharmacol Ther

526

337

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“…The polysaccharide produced by some strains of bacteria has an antitumour effect (Kitazawa et al 1990) and antimutagenic properties (Hosono et al 1989). However, other proteolytic compounds present in dairy products also contribute to antimutagenicity (Abdelali et al 1995;Nadathur et al 1995;Bodana and Rao 1990). The water-soluble and DMSOsoluble compounds of the acetone extracts of B. longum PS + had less antimutagenicity than the fermented milk, and thus the antimutagenicity contributed by polysaccharide cannot be ruled out, since it was probably not extracted by acetone.…”

Section: Assay For Antimutagenicitymentioning

confidence: 99%

“…Fermented milk products prepared with lactic acid bacteria are known to exhibit antimutagenicity towards amino acid pyrolysates such as 3-amino-1,4-dimethyl- 5Hpyrido[4,indole (Trp-P-1), and 3-amino-1-methyl- 5Hpyrido[4,indole (Trp-P-2) (Hosono et al , 1988(Hosono et al , 1990Hosoda et al 1996). However, the antimutagenicity was contributed by both lactic acid bacteria (Pool-Zobel et al 1993;Renner and Munzner 1991;Ingrid and Hosono 1996) and the milk components formed during fermentation (Nadathur et al 1995;Abdelali et al 1995).…”

mentioning

confidence: 99%

The antimutagenic properties of a polysaccharide produced by Bifidobacterium longum and its cultured milk against some heterocyclic amines

Sreekumar¹,

Hosono²

1998

Can. J. Microbiol.

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The antimutagenicity and fermentation pattern of three Bifidobacterium longum strains (B. longum, B. longum PS+, and B. longum PS-) in skim milk were studied. The increase in fermentation time significantly increased antimutagenicity with all strains tested against the mutagenicity of both 3-amino-1,4-dimethyl-5H-pyrido-[4,3-b]indole (Trp-P-1) and 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) in an Ames-like test using streptomycin-dependent strain SD510 of Salmonella typhimurium TA98. Bifidobacterium longum PS+, a polysaccharide-producing strain, had a longer lag phase but showed the highest inhibition percentage against both mutagens tested. The viability of B. longum PS+ cells was not affected by the low pH of 4.1, probably owing to the protection offered by the polysaccharide produced. The antimutagenicity of the fermented milk against Trp-P-1 was dose dependent. The strains were also able to bind with different amino acid pyrolysates, and B. longum showed the highest binding. Acetone extracts of fermented skim milk dissolved in water showed less antimutagenicity than extracts dissolved in dimethylsulfoxide. The isolated crude polysaccharide from B. longum PS+ showed a dose-dependent inhibition of the mutagenicity of Trp-P-1. Thus, we conclude that the polysaccharide of B. longum PS+ can be used as an antimutagen.

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“…In fact, protection against mutations could be beneficial at least in the initial stages of tumor development. Some natural compounds have recently been described as inhibitors of the mutagenic effect in bacteria [3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of propolis and bee venom on the mutagenicity of some direct- and indirect-acting mutagens

Varanda

Monti

Tavares

1999

Teratogenesis Carcinog. Mutagen.

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Antimutagenicity of components of dairy products

Cited by 36 publications

References 24 publications

Review article: bifidobacteria as probiotic agents – physiological effects and clinical benefits

Review article: bifidobacteria as probiotic agents – physiological effects and clinical benefits

The antimutagenic properties of a polysaccharide produced by Bifidobacterium longum and its cultured milk against some heterocyclic amines

Inhibitory effect of propolis and bee venom on the mutagenicity of some direct- and indirect-acting mutagens

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