Antimutagenicity and anticlastogenicity of glutinous purple rice hull using in vitro and in vivo testing systems

Sankam, Paweena; Punvittayagul, Charatda; Sringam, Korawan; Chaiyasut, Chaiyavat; Wongpoomchai, Rawiwan

doi:10.1007/s13273-013-0021-4

Cited by 17 publications

(19 citation statements)

References 29 publications

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“…Glutathione S -transferase (GST) activity was examined using 1-chloro,2,4-dinitrobenzene (CDNB) as a substrate [42]. Liver cytosol was mixed with a reaction mixture that contained glutathione and CDNB and then incubated at 37 °C.…”

Section: Methodsmentioning

confidence: 99%

Protective Effects of Defatted Sticky Rice Bran Extracts on the Early Stages of Hepatocarcinogenesis in Rats

et al. 2019

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Use of natural products is one strategy to lessen cancer incidence. Rice bran, especially from colored rice, contains high antioxidant activity. Cancer chemopreventive effects of hydrophilic purple rice bran extract (PRBE) and white rice bran extract (WRBE) on carcinogen-induced preneoplastic lesion formation in livers of rats were investigated. A 15-week administration of PRBE and WRBE did not induce hepatic glutathione S-transferase placental form (GST-P) positive foci formation as the biomarker of rat hepatocarcinogenesis. PRBE and WRBE at 500 mg/kg body weight significantly decreased number and size of GST-P positive foci in diethylnitrosamine (DEN)-initiated rats. The number of proliferating nuclear antigen positive hepatocytes were also reduced in preneoplastic lesions in both PRBE and WRBE fed DEN-treated rats. Notably, the inhibitory effect on GST-P positive foci formation induced by DEN during the initiation stage was found only in rats treated by PRBE for five weeks. Furthermore, PRBE attenuated the expression of proinflammatory cytokines involving genes including TNF-α, iNOS, and NF-κB. PBRE contained a higher number of anthocyanins and other phenolic compounds and vitamin E. PRBE might protect DEN-induced hepatocarcinogenesis in rats via attenuation of cellular inflammation and cell proliferation. Anthocyanins and other phenolic compounds, as well as vitamin E, might play a role in cancer chemopreventive activity in rice bran extract.

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Section: Methodsmentioning

confidence: 99%

Protective Effects of Defatted Sticky Rice Bran Extracts on the Early Stages of Hepatocarcinogenesis in Rats

et al. 2019

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“…However, a decreased yield was observed in black rice compared to the white pericarp lines with similar background (Ji et al 2012). Rice hull has long been treated as a waste product, but studies have demonstrated the antimutagenic and anticlastogenic potential of purple rice hull (Baek et al 2015;Sankam et al 2013). 'Green super rice' has become the goal of rice breeding since the beginning of this century and high yield with good quality is the main pursuit of rice breeders (Zhang 2007).…”

Section: Further Researchmentioning

confidence: 99%

WITHDRAWN: How is Rice Organ Painted: the Genetic Basis of Anthocyanin Biosynthesis in Rice

Xia

Zhou

et al. 2020

Preprint

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Anthocyanins are major subclasses of flavonoids, which have diverse biological functions and benefit human health. In Oryza sativa, organs exhibit various color due to the accumulation of anthocyanins. On the other hand, anthocyanins biosynthesis is a domestication related trait. Revealing the genetic basis of anthocyanins biosynthesis in rice is not only important for the engineering of anthocyanins, but also helpful for understanding the evolutionary story of Oryza sativa. Here we summarize the recent progresses in rice anthocyanins biosynthesis, including the anthocyanins biosynthetic pathway, the genes that participate in anthocyanins biosynthesis, the cloning of anthocyanins related genes and the domestication process of rice anthocyanins. Possible applications of rice anthocyanin biosynthesis genes in rice breeding and the remaining unknown mechanism of anthocyanins accumulation in stigma, apiculus and awn are also discussed.

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“…quantified using a UV detector at a wavelength of 330nm (Sankam et al, 2013). The standard chromatograms are presented in Figure 1A-1D.…”

Section: 9517 Mutagenicity and Antimutagenicity Of Hydrophilic And Lmentioning

confidence: 99%

“…In addition, Kim et al (2007) identified momilactone B from rice hull as the active compound against human colon cancer cells. Our group found that the dichloromethane extract of purple rice hull had antimutagenic effects in the Ames test and anticlastogenic effects on diethylnitrosamine-induced micronucleus formation in rat liver (Sankam et al, 2013). Based on these observations, rice hull would appear to be a source of natural antimutagenic compounds.…”

mentioning

confidence: 96%

Mutagenicity and Antimutagenicity of Hydrophilic and Lipophilic Extracts of Thai Northern Purple Rice

Punvittayagul¹,

Sringarm²,

Chaiyasut³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Antimutagenicity and anticlastogenicity of glutinous purple rice hull using in vitro and in vivo testing systems

Cited by 17 publications

References 29 publications

Protective Effects of Defatted Sticky Rice Bran Extracts on the Early Stages of Hepatocarcinogenesis in Rats

Protective Effects of Defatted Sticky Rice Bran Extracts on the Early Stages of Hepatocarcinogenesis in Rats

WITHDRAWN: How is Rice Organ Painted: the Genetic Basis of Anthocyanin Biosynthesis in Rice

Mutagenicity and Antimutagenicity of Hydrophilic and Lipophilic Extracts of Thai Northern Purple Rice

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