Antimutagenic effect of sage tea in the wing spot test of Drosophila melanogaster

Patenković, Aleksandra; Stamenković‐Radak, Marina; Banjanac, Tijana; Andjelković, Marko

doi:10.1016/j.fct.2008.10.024

Cited by 31 publications

(22 citation statements)

References 38 publications

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“…Sage may also inhibit pro-oxidant-induced lipid peroxidation in rat brain and liver homogenates (Oboh and Henle, 2009). Further in vitro models showed Salvia as possibly being antiangiogenic, antimutagenic, antidiabetic, and gastroprotective (Lima et al, 2006; Mayer et al, 2009; Patenkovic et al, 2009; Keshavarz et al, 2010). Although the underlying mechanisms of action are unknown, polyphenols such as carnosol, carnosic acid, rosmanol, apigenin, hispidulin, caffeic acid, and ursolic acid have been discussed as active compounds for these pharmacological effects (Imanshahidi and Hosseinzadeh, 2006).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant capacity and polyphenolic composition as quality indicators for aqueous infusions of Salvia officinalis L. (sage tea)

Walch¹,

Tinzoh

Zimmermann

et al. 2011

Front. Pharmacol.

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Sage (Salvia officinalis L.) is used as an herbal medicinal product, with the most typical form of application as infusion with boiling water (sage tea). The well-established traditional uses include symptomatic treatment of mild dyspeptic complaints, the treatment of inflammations in the mouth and the throat, and relief of excessive sweating and relief of minor skin inflammations. In this study, sage teas prepared from commercially available products were chemically analyzed for polyphenolic content using liquid chromatography, for antioxidant potential using the oxygen radical absorbance capacity method, and for the Folin–Ciocalteu (FC) index. The sage teas showed a high variation for all parameters studied (up to 20-fold differences for rosmarinic acid). Univariate and multivariate analyses showed that the antioxidant potential, which varied between 0.4 and 1.8 mmol trolox equivalents/100 mL, was highly dependent on rosmarinic acid and its derivatives. The FC index also showed a high correlation to these polyphenols, and could therefore be used as a screening parameter for sage tea quality. The considerable differences in polyphenolic composition and antioxidant capacity between the brands lead to a demand for quality standardization, especially if these sage teas are to be used for therapeutic purposes. Further research also appears to be necessary to characterize the dose–benefit relationship, as sage may also contain a constituent (thujone) with potentially adverse effects.

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Section: Introductionmentioning

confidence: 99%

Antioxidant capacity and polyphenolic composition as quality indicators for aqueous infusions of Salvia officinalis L. (sage tea)

Walch¹,

Tinzoh

Zimmermann

et al. 2011

Front. Pharmacol.

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“…Besides our results, no antigenotoxic effect of Thu was reported, but there is evidence about antigenotoxicity of plant extracts containing high proportion of Thu [45,117].…”

Section: Mutagenesis (%)mentioning

confidence: 61%

“…Numerous biological activities of different extracts of Salvia and Ocimum species have been described, including antimicrobial, anti-inflammatory, antioxidative, antidiarrheal, blood-sugar lowering, immunomodulatory, a nervous system stimulatory, spasmolytic, and cholinergic binding [29][30][31][32][33][34][35][36][37][38][39][40]. Several reports also indicate antigenotoxic and chemopreventive activities of different extracts from Salvia and Ocimum species [41][42][43][44][45].…”

Section: Medical Properties Of Sage and Basilmentioning

confidence: 99%

Molecular Mechanisms of Action of Antimutagens from Sage (Salvia officinalis) and Basil (Ocimum basilicum)

Nikolić¹,

Mitić-Ćulafić²,

Vuković-Gačić³

et al. 2012

Mutagenesis

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“…Sage essential oils have been studied for their toxicity and antimutagenic , antimicrobial , antiviral , preservative , immunomodulatory , antioxidant , larvicidal , and anticancer properties. However, a significant amount of terpenoids is also present in sage teas, contributing to their antioxidant , hepatotoxic , antimutagenic , and antidiabetic effects.…”

Section: Introductionmentioning

confidence: 99%

Comparison of different extraction methods for the determination of α- and β-thujone in sage (Salvia officinalis L.) herbal tea

et al. 2013

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Salvia officinalis L. (sage) is an important industrial plant used both for food and pharmaceutical purposes. The terpene fraction of this plant is responsible for many of its therapeutic and culinary properties. We used different extraction methods Tenax TA® purge and trap, headspace (HS) solid-phase microextraction, HS sorptive extraction, and stir bar sorptive extraction to analyze the terpene fraction extracted from sage tea by GC-MS. Twenty compounds were identified, including α-, β-thujone, and several other oxygenated monoterpenes (1,8-cineole, linalool, camphor, boneol, and bornyl acetate) and oxygenated sesquiterpenes (caryophyllene oxide, viridiflorol, humulene epoxide I, II, and III). Tenax TA® and HS sorptive extraction extracted a lower number of identified compounds, whereas HS solid-phase microextraction allowed the complete extraction of volatiles with particular reference to α- and β-thujone. The importance of the determination of thujones content in sage herbal tea is also discussed.

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Antimutagenic effect of sage tea in the wing spot test of Drosophila melanogaster

Cited by 31 publications

References 38 publications

Antioxidant capacity and polyphenolic composition as quality indicators for aqueous infusions of Salvia officinalis L. (sage tea)

Antioxidant capacity and polyphenolic composition as quality indicators for aqueous infusions of Salvia officinalis L. (sage tea)

Molecular Mechanisms of Action of Antimutagens from Sage (Salvia officinalis) and Basil (Ocimum basilicum)

Comparison of different extraction methods for the determination of α- and β-thujone in sage (Salvia officinalis L.) herbal tea

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