2013
DOI: 10.1089/jmf.2013.0006
|View full text |Cite
|
Sign up to set email alerts
|

Antimutagenic Effect of Origanum majorana L. Essential Oil Against Prallethrin-Induced Genotoxic Damage in Rat Bone Marrow Cells

Abstract: This study aimed to investigate the genotoxic and cytotoxic potential of prallethrin in rat bone marrow cells and the protective effect of Origanum majorana L. essential oil (EO). Our results demonstrated that prallethrin at dose 64.0 mg/kg body weight (b.wt.) (1/10 LD50), has a clastogenic/genotoxic potential as shown by the high percentage of chromosomal aberration (CA) and micronucleus (MN) in the bone marrow cells of male rats, whereas the combined treatment of prallethrin and O. majorana EO resulted in th… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
17
0

Year Published

2014
2014
2023
2023

Publication Types

Select...
9

Relationship

1
8

Authors

Journals

citations
Cited by 15 publications
(18 citation statements)
references
References 46 publications
1
17
0
Order By: Relevance
“…Similarly, the combined treatment of prallethrin and EOs from O. majorana in bone marrow cells of rats, resulted in the reduction of the chromosomal aberration (54.54%), thus, EOO demonstrated to have genotoxic effect. The effects could be attributed to the scavenge ability of EOO and its contribution in hindering lipid peroxidation [ 162 ].…”
Section: Biological Activities Of Essential Oils Of Oregano Speciementioning
confidence: 99%
See 1 more Smart Citation
“…Similarly, the combined treatment of prallethrin and EOs from O. majorana in bone marrow cells of rats, resulted in the reduction of the chromosomal aberration (54.54%), thus, EOO demonstrated to have genotoxic effect. The effects could be attributed to the scavenge ability of EOO and its contribution in hindering lipid peroxidation [ 162 ].…”
Section: Biological Activities Of Essential Oils Of Oregano Speciementioning
confidence: 99%
“…Essential oils from oregano have been proposed as dietary inhibitors of mutagenesis and carcinogenesis [ 162 ]. Nonetheless, investigations about anticarcinogenic effect of EOO are scarce.…”
Section: Biological Activities Of Essential Oils Of Oregano Speciementioning
confidence: 99%
“…Other promising applications have been proposed for Helichrysum italicum (Roth) G. Don as antispastic [ 52 ], Pelargonium roseum L'hér. as anti-inflammatory [ 53 ], and O. majorana L. as antimutagenic agent [ 54 ].…”
Section: Medical Uses Of Essential Oils In Human Diseasesmentioning
confidence: 99%
“…Other promising applications have been proposed for Helichrysum italicum as antispastic [44], rose geranium as anti-inflammatory [45], Origanum majorana as antimutagenic [46], and many others, but clinical validation is not ready at the moment.…”
Section: Miscellaneamentioning
confidence: 99%