Antimutagenic effect of Dioscorea Pentaphylla on genotoxic effect induced by methyl methanesulfonate in the drosophila wing spot test

Prakash, G. K. Surya; Hosetti, B. B.; Dhananjaya, BL

doi:10.4103/0971-6580.155341

Cited by 15 publications

(4 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Actually, a growing number of studies have identified different plants extracts with antigenotoxic potential, such as: Mentha longifolia (Al-Ali et al 2014), Dioscorea pentaphylla (Prakash et al 2014), Lilium candidum (Jovtchev et al 2014), Eucalyptus Gunnii (Bugarin et al 2014), Camellia sinensis (Bhattacharya et al 2014), Curcuma longa (Liju et al 2014), Celtis iguanaea (Borges et al 2013), Solanum paniculatum (Vieira et al 2013), Synadenium umbellatum (Melo-Reis et al 2011), Ginkgo biloba (Vilar et al 2009), and others. Thus, there has been growing interest in finding and using natural plant products to reduce genotoxic and/or carcinogenic effects.…”

Section: Introductionmentioning

confidence: 99%

Antigenotoxicity protection of Carapa guianensis oil against mitomycin C and cyclophosphamide in mouse bone marrow

Lemes

Chaves

Silva

et al. 2017

An. Acad. Bras. Ciênc.

View full text Add to dashboard Cite

The aim of this study was to evaluate the possible protective of C. guianensis oil against MMC and CP, which are direct-and indirect-acting chemical mutagens, using the micronucleus test. Three experiments were performed. First the C. guianensis oil was co-administered to mice at doses of 250, 500 and 1000 mg/ kg bw with 4 mg/kg bw MMC or 50 mg/kg bw CP. Second, the mutagenic drug (CP) was administered ip 50 mg/kg bw and after 6 and 12 hours 250 and 500 mg/kg bw of C. guianensis oil were administered. In the last, C. guianensis oil was administrated (250 and 500 mg/kg bw) during five days and after it was administered ip 50 mg/kg bw CP. The results obtained showed that the C. guianensis oil is not cytotoxic neither genotoxic to mouse bone marrow. Regarding the antimutagenic effect, all doses of C. guianensis oil were significantly (p < 0.05) effective in reducing the frequency of micronucleated polychromatic erythrocytes, when compared with MMC or CP alone. Based on these results, our results suggest that the C. guianensis oil shows medicinal potential as an antimutagenic agent, modulating the mutagenicity caused by both direct-and indirect-acting chemical mutagens, in a mammalian model.

show abstract

Section: Introductionmentioning

confidence: 99%

Antigenotoxicity protection of Carapa guianensis oil against mitomycin C and cyclophosphamide in mouse bone marrow

Lemes

Chaves

Silva

et al. 2017

An. Acad. Bras. Ciênc.

View full text Add to dashboard Cite

show abstract

“…[22] In another study, it was found that the different concentrations of Dioscorea pentaphylla significantly inhibit the mutagenic effects induced by a potent mutagen methyl methanesulphonate (MMS). [23] They also found that the methanolic extract was highly antimutagenic in comparison to petroleum ether and chloroform. Thus, due to non-mutagenic effects and protection against known mutagens, CT can provide a rationale for use in chemotherapeutic medicine.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Mutagenic and Antimutagenic Activity of Methanol Extract of Cousinia thomsonii against Cyclophosphamide

Khan

Bashir

Gulzar

et al. 2020

Int. J. Pharm. Sci. Drug Res.

View full text Add to dashboard Cite

The present study was conducted to evaluate the mutagenic and antimutagenic potential of Cousinia thomsonii (CT) extract in bone marrow cells of male wistar rats using some important parameters like micronucleated polychromatic erythrocyte (MnPCE), mitotic index (MI), chromosomal aberrations (CA) and polychromatic erythrocyte to normochromatic erythrocyte ratio (PCE/NCE). 30 male rats of wistar strain were divided into 6 groups with 5 rats each group. Group 1 rats were taken as negative control having free access to distilled water and rat feed. Group 2 rats were taken as positive control treated with mutagen cyclophosphamide (CP) at dose of 60 mg/kg b wt. for 2 days. Group 3 and 4 were treated with CT extract at dose of 100 and 200 mg/kg b wt. for 20 days. Group 5 and 6 were treated with 100 and 200 mg/kg b wt of CT extract for first 18 days and for last 2 days with CP at dose concentration of 60 mg/kg. It was found that rats treated with CT extract alone did not produce any significant changes in MnPCE, PCE/NCE ratio, CA and MI when compared with control treated rats (group 1). However in group 5 and 6 rats treated with CT extract in combination with CP a protective effect was observed against the cyclophosphamide induced cellular mutagenicity. In concluding remark Cousinia thomsonii was found to show antigenotoxic potential and also produce protective antimutagenic effects against CP induced chromosomal damage.

show abstract

“…In general, dioscorea is vines, (Kamaruddin et al, 2020;Nasriyah et al, 2011) and contains about 75-84% of starch that includes small compounds, such as proteins, vitamins, lipids, and minerals (Shajeela, 2011). The active compounds in dioscorea, such as steroidal sapogenins, glycans, alkaloids, tannins, and saponins, give the characteristic of spicy and bitter tastes (Prakash et al, 2014).…”

Section: Dioscorea Tubersmentioning

confidence: 99%

The Utilization of Dioscorea Tuber in Self-Rising Starch: a Review

Harni¹,

Anggraini²,

Rini³

et al. 2022

J. appl. agricultural sci. technol.

View full text Add to dashboard Cite

Self-rising starch is a development product of self-rising flour. This product minimizes the process, especially in the salt and leavening agent weighing stage, so that it reduces the time in the serving process. Self-rising flour is generally made of wheat flour. Currently, due to some medical considerations, many people cannot consume this product. Based on some research results, gluten compound in wheat flour or wheat triggers for the development of type-1 diabetes. This fact has caused Indonesia to be ranked fifth in the world for the diabetic diseases. Thus, one of the ways to overcome this problem is by utilizing the raw materials originating from Indonesia too, namely tubers. Indonesia has a variety of tubers. Some of these tubers, however, have not been explored. These tubers have not only the function as the good sources of carbohydrates but also the bioactive compounds and more functional values, such as water soluble polysaccharides (WSP), diosgenin, inulin and glycemic index. They increase the functional properties of the starch that are produced. The tubers that currently have not been cultivated are the genus Dioscorea. The various tubers that are included in dioscorea family are uwi, gembili, gadung, tomberoso and jebubuk. All of these tubers are good sources of carbohydrates. Uwi, gembili and gadung are tubers that have been cultivated by the people for many years. On the hand, tomberoso and jebubuk tubers grow wildly in the forest that only become the foods for the wild animals in it. The starch derived from the disccorea tubers can be used as self-rising starch because it has the property as food developer. It contains high carbohydrates and bio-active compound, therefore, it is healthier to consume.

show abstract

Antimutagenic effect of Dioscorea Pentaphylla on genotoxic effect induced by methyl methanesulfonate in the drosophila wing spot test

Cited by 15 publications

References 33 publications

Antigenotoxicity protection of Carapa guianensis oil against mitomycin C and cyclophosphamide in mouse bone marrow

Antigenotoxicity protection of Carapa guianensis oil against mitomycin C and cyclophosphamide in mouse bone marrow

Evaluation of Mutagenic and Antimutagenic Activity of Methanol Extract of Cousinia thomsonii against Cyclophosphamide

The Utilization of Dioscorea Tuber in Self-Rising Starch: a Review

Contact Info

Product

Resources

About