Antimutagenic activity of anthocyanins isolated from Aronia melanocarpa fruits

Gąsiorowski, Kazimierz; Szyba, K.; Brokos, Barbara; Koz.xl;laczyńska, Beata; Jankowiak-Wz.xl;lodarczyk, Magda; Oszmiański, Jan

doi:10.1016/s0304-3835(97)00248-6

Cited by 147 publications

(90 citation statements)

References 40 publications

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“…Anthocyanins isolated from Aronia markedly inhibited the mutagenic activity of benzo[a]pyrene and 2-aminofluorene in the Ames test as well as in the sister chromatid exchange assay with cultured human lymphocytes [89]. Furthermore, Aronia juice intake was shown to inhibit the endogenous generation of N-nitrosamines in rats treated with aminopyrin plus sodium nitrite.…”

Section: Antimutagenic Effectsmentioning

confidence: 94%

“…Phenolic compounds isolated from berries of Aronia melanocarpa also exert an antimutagenic activity as documented in [89], [90]. Anthocyanins isolated from Aronia markedly inhibited the mutagenic activity of benzo[a]pyrene and 2-aminofluorene in the Ames test as well as in the sister chromatid exchange assay with cultured human lymphocytes [89].…”

Section: Antimutagenic Effectsmentioning

confidence: 95%

See 1 more Smart Citation

Chokeberry(Aronia melanocarpa)– A Review on the Characteristic Components and Potential Health Effects

Kulling¹,

Rawel²

2008

Planta Med

451

458

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Botanical Background and Cultivation ! Aronia berries originate from the eastern parts of North America and East Canada [1], [2], [3]. Their migration to Europe occurred around 1900 via Germany to Russia and back. Around 1946 the plant was established as a cultivar in the former Soviet Union. More recently it is cultivated also in East European countries and Germany (Oberlausitz) [1], [2]. The genus name Aronia has been replacing the common name, chokeberry. Two species can be distinguished: Aronia melanocarpa [Michx.] Elliot (black chokeberry, Aronia noir) and Aronia arbutifolia [L.] Elliot (red chokeberry, Aronia rouge) [3]. A third entity is intermediate and has variously been considered a species (A. prunifolia), a variety of each of the other two, or a hybrid [3]. The other common names for Aronia besides chokeberries include black apple berry and rowanberries (Sorbus aucuparia L.), whereby in the latter case the hybrids of rowanberry with Aronia are likely to be addressed [4], [5], [6]. Aronia is a member of the Rosaceae family, and the cultivars used for fruit production are from the species Aronia melanocarpa [6], [7], [8], [9]. Cultivars have been bred for larger edible fruits and ornamental value. The plants have no known pest problems [10]. Some cultivars are bred of true black chokeberry (Aronia melanocarpa) and some are hybrid cultivars (e. g., Aronia x Sorbus) [5], [11]. The more important cultivars include "Nero" (Czechia), "Rubina" (crossing from Russian and Finnish plants), "Viking" (Finland), "Kurkumäcki" (Finland), "Hugin" (Sweden), "Fertödi" (Hungary) and "Aron" (Denmark) [2]. "Viking" and "Nero" are cultivars that are commonly available in North American plant catalogues [7]. The Aronia shrubs can grow to a height of 2-3 m, which produce in May to June umbels of some 30 small white flowers, ripening to bright red (red chokeberry) or to purplish black berries (black chokeberry; Ø 6-13 mm, 0.5-2 g) [1], [2], [8], [12]. Harvest is performed mechanically between August and September. Five to twelve tons per hectare can be expected in about five years, once plants have matured [7], [8]. The effect of fertiliser rate on fruit quality parameters in the black chokeberry showed that an increased fertiliser application results in increased growth and higher yield whereas pigment content and total acidity decreased. Maximum production of anthocyanins per plant was obtained with a medium high fertiliser rate (50 kg N/ha, 44 kg P/ha, 100 kg K/ ha) [13]. The content of undesirable brown compounds and that of desirable anthocyanins is also dependent on maturation as documented in [11]. A recent study illustrates that applied fertilization may exert a differential influence on the chemical composition of Aronia fruits especially with regard to sugar content and the quantity

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Section: Antimutagenic Effectsmentioning

confidence: 94%

Section: Antimutagenic Effectsmentioning

confidence: 95%

Chokeberry(Aronia melanocarpa)– A Review on the Characteristic Components and Potential Health Effects

Kulling¹,

Rawel²

2008

Planta Med

451

458

View full text Add to dashboard Cite

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“…Extracts of skullcap root (SR) and buckwheat husk (BH) and stalk (BS) were obtained from the Department of Fruit, Vegetable and Cereal Technology, Wrocław University of Environmental and Life Sciences. Polyphenols were isolated from skullcap root and buckwheat husk and stalk using the method described by Gąsiorowski et al [48]. The 1,2-dimyristoyl-snglycero-3-phosphatidylcholine (DMPC) was purchased from Sigma-Aldrich, Steinheim, Germany.…”

Section: Experimental Materialsmentioning

confidence: 99%

Interaction of skullcap (Scutellaria baicalensis Georgi) and buckwheat (Fagopyrum esculentum Moench) extracts with lipid bilayers

Pruchnik

Włoch

Żyłka

et al. 2015

J Therm Anal Calorim

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In this paper, we report the effect of skullcap (Scutellaria baicalensis Georgi) root (SR) and buckwheat (Fagopyrum esculentum Moench) husk and stalk (BH and BS) extracts on lipid organization and fluidity of model membranes, examined by monitoring of the thermotropic phase transition of dimyristoylphosphatidylcholine (DMPC) with differential scanning calorimetry, attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and fluorescence spectroscopy. Despite the very high biological activity of these extracts, such a study has not been undertaken previously. Calorimetric results on the thermotropic parameters of DMPC membranes suggest that BH and BS extracts modify them to a greater extent than SR. Fluorescence and ATR-FTIR results confirm that the compounds contained in the SR extract concentrate in the hydrophilic area of the DMPC bilayer, causing an increase in the order of the polar heads of the lipid, and they do not penetrate the hydrophobic area. Compounds contained in the BS and BH extracts also concentrate in the hydrophilic area of the bilayer; however, they partially affect the hydrophobic-hydrophilic interface of the bilayer as well as the upper part of the acyl chain region.

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“…14 The antimutagenic activity of anthocyanidins was earlier established by Gasiorowski et al, whose results revealed that these compounds, isolated from the fruit of Aronia melanocarpa, sufficiently inhibit the mutagenic activity of benzo(a) pyrene and 2-aminofluorene in the Ames test. 16 Hence, CYP inhibition by anthocyanin compounds might be considered as antimutagenic, given that these enzymes contribute to carcinogenesis in several organs [17][18][19][20] and increase DNA toxicity and damage. 21 Therefore, in order to evaluate a series of anthocyanin derivatives as CYP3A4 inhibitors, two computational approaches were used in the present study, ie, 3D-QSAR and molecular docking techniques, to analyze and match experimentally derived CYP3A4 half maximal inhibitory concentration (IC 50 ) values to their predicted ones together with the binding affinity modes.…”

mentioning

confidence: 99%

Three-dimensional quantitative structure–activity relationship and docking studies on a series of anthocyanin derivatives as cytochrome P450 3A4 inhibitors

Shityakov¹,

Broscheit²,

Roewer³

et al. 2013

Molecular Immunology

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Antimutagenic activity of anthocyanins isolated from Aronia melanocarpa fruits

Cited by 147 publications

References 40 publications

Chokeberry(Aronia melanocarpa)– A Review on the Characteristic Components and Potential Health Effects

Chokeberry(Aronia melanocarpa)– A Review on the Characteristic Components and Potential Health Effects

Interaction of skullcap (Scutellaria baicalensis Georgi) and buckwheat (Fagopyrum esculentum Moench) extracts with lipid bilayers

Three-dimensional quantitative structure–activity relationship and docking studies on a series of anthocyanin derivatives as cytochrome P450 3A4 inhibitors

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