Antimutagenic activities of common vegetables and their chlorophyll content

Lai, Chiu-Nan; Butler, Mary Ann; Matney, Thomas S.

doi:10.1016/0165-1218(80)90057-9

Cited by 143 publications

(48 citation statements)

References 5 publications

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“…Also, Cu-Chl and natural chlorophyll exhibited similar inhibitory activity at equivalent levels (Lai, Butler, & Matney, 1980). Later, also in studies with S. typhimurium, Ong, Whong, Stewart, and Brockman (1989) compared the antimutagenic activities of chlorophyllin, retinol, β-carotene and vitamins C and E against five mutagenic complex mixtures containing BP and other polycyclic aromatic hydrocarbons, including diesel emission particles, fried beef and airborne particles.…”

Section: Introductionmentioning

confidence: 94%

Copper chlorophyllin: A food colorant with bioactive properties?

Tumolo

Lanfer-Marquez

2012

Food Research International

119

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Section: Introductionmentioning

confidence: 94%

Copper chlorophyllin: A food colorant with bioactive properties?

Tumolo

Lanfer-Marquez

2012

Food Research International

119

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“…Involvement of these phytochemicals (β-carotene and xanthophylls) has also been reported in green peppers using S. typhimurium tester strain YG1024 against 1-nitropyrene (1-NP), 1,6-dinitropyrine (1,6-DNP), and 1,8-dinitropyrine (1,8-DNP) [124]. Antimutagenicity of aqueous and acetone extracts of vegetables against 3-methylcholanthrene and benzo[a]pyrene in the Ames test (gene reversion mutagenesis/ mammalian microsomal activation assay) has also been reported to be correlated with the chlorophyll content [137]. This inhibitory activity of chlorophyll was comparable to the sodium copper chlorophyll in level.…”

Section: Non-polar Componentsmentioning

confidence: 99%

Fruits and Vegetables as Dietary Sources of Antimutagens

Gautam¹,

Saxena²,

Kumar³

2016

J Food Chem Nanotechnol

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Mutation is the process leading to heritable changes in the genetic material of an organism and caused mainly by the external factors, including chemical and physical agents, or can also occur spontaneously due to errors in DNA replication, repair, and recombination. Agents contributing to the mutagenic burden in the environment could be from industrial sources, wide spectrum applications of biocides in the agriculture, and other contaminants. As many of these mutagenic chemicals can induce severe disorders in humans including cancer and a large spectrum of inherited diseases, it is important to detect such mutagenic agents precisely and rapidly, and also look for an approach to combat them. Natural occurring dietary antimutagens primarily from health protective foods such as fruits and vegetables could provide a mechanism to counteract the deleterious effect of these mutagens. The World Health Organization (WHO) indicates that one-third of all cancer deaths are preventable and that diet is closely linked to cancer prevention. These health protective phytochemicals particularly antimutagenic ones could provide an effective solution to these concerns. The current review deals with understanding of the mutagenic events, methods of its analysis and a brief compilation of the existing scientific findings related to the dietary sources having potential to counteract the effects of the mutagenic exposures from different sources. The review would provide an opportunity to look into the science, think about the possible future perspectives and mechanism to translate the outcome of the scientific research for benefits of the mankind.

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“…These naturally occurring Chl derivatives are abundant in green vegetables, but only a few studies have explored their chemopreventative properties. [19][20][21] Previously, Hsu et al 22 reported that the antioxidative capacities of Chl-related compounds (CRCs: Chlide a and b, and Pb a and b) can protect human lymphocyte DNA from hydrogen peroxide-induced DNA damage. Recently, Subramoniam et al 23 showed that Chl a has antioxidant and anti-inflammatory activities in human embryonic kidney (HEK) 293 cells through inhibiting expression of the TNF-a gene.…”

Section: Introduction Ementioning

confidence: 99%

Chlorophyll-Related Compounds Inhibit Cell Adhesion and Inflammation in Human Aortic Cells

Lin

Hsu

Huang

et al. 2013

Journal of Medicinal Food

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The objectives of this study were to investigate the effects of chlorophyll-related compounds (CRCs) and chlorophyll (Chl) a + b on inflammation in human aortic endothelial cells. Adhesion molecule expression and interleukin (IL)-8, nuclear factor (NF)-jB p65 protein, and NF-jB and activator protein (AP)-1 DNA binding were assessed. The effects of CRCs on inflammatory signaling pathways of signal transducers and activators of transcription 3 (STAT3) and mothers against decapentaplegic homolog 4, respectively induced by IL-6 and transforming growth factor (TGF)-b, in human aortic smooth muscle cells cultured in vitro were also investigated. HAECs were pretreated with 10 lM of CRCs, Chl a + b, and aspirin (Asp) for 18 h followed by tumor necrosis factor (TNF)-a (2 ng/mL) for 6 h, and U937 cell adhesion was determined. TNF-a-induced monocyte-endothelial cell adhesion was significantly inhibited by CRCs. Moreover, CRCs and Chl a + b significantly attenuated vascular cell adhesion molecule-1, intercellular adhesion molecule-1, and IL-8 expressions. Treatments also significantly decreased in NF-jB expression, DNA binding, and AP-1 DNA binding by CRCs and Asp. Thus, CRCs exert anti-inflammatory effects through modulation of NF-jB and AP-1 signaling. Ten micromoles of CRCs and Asp upregulated the expression of mothers against decapentaplegic homolog 4 (Drosophila) (SMAD4) in the TGF-b receptor signaling pathway, and SMAD3/4 transcription activity was also increased. Ten micromoles of CRCs were able to potently inhibit STAT3-binding activity by repressing IL-6-induced STAT3 expression. Our results provide a potential mechanism that explains the anti-inflammatory activities of these CRCs.

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Antimutagenic activities of common vegetables and their chlorophyll content

Cited by 143 publications

References 5 publications

Copper chlorophyllin: A food colorant with bioactive properties?

Copper chlorophyllin: A food colorant with bioactive properties?

Fruits and Vegetables as Dietary Sources of Antimutagens

Chlorophyll-Related Compounds Inhibit Cell Adhesion and Inflammation in Human Aortic Cells

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