Antimutagenic action of cobaltous chloride on radiation-induced mutations in cultured Chinese hamster cells

Current aspects in metal genotoxicity

“…1986, Leit~o et al 1993) and lowered the number of spontaneous mutations in a Bacillus subtilis mutator strain (Inoue et al 1981). In contrast, in mammalian cells in culture, Co(II) increased the frequency of UV-induced mutations and sister chromatid exchanges (Hartwig et al 1991), but decreased the mutation frequency and enhanced the cytotoxicity in combination with ]/-rays (Yokoiyama et al 1990). As possible reason for the enhancing effects in combination With UV light, Co(II) has been shown to completely block the removal of UV-induced pyrimidine dimers at non-cytotoxic concentrations.…”

Antioxidant Defense System in Cobalt Treated Diabetic Rat Lung

“…Altough cobalt is an essential trace element in the human body, excessive intake of cobalt or overexposure to this metal are known to be toxic, carcinogenic and mutagenic (31,32). Despite the toxic effects of cobalt protects the liver against acetaminophen toxicity and has antimutagenic action against radiation-induced mutations (33). The mechanims of the toxicity produced by excessive intake of cobalt are not entirely clear, and it is possible that formation of oxygen-derived species may be involved, in that cobalt salts have been observed to stimulate lipid peroxidation in some in vitro systems (34).…”