Antimutagenesis in microbial systems.

“…In carrying out studies on antimutagenesis it is always important to be sure that effects noted are due to "true antimutagenesis" and not to "apparent antimutagenesis" [1]. We test our compounds at concentrations that are 50% or less of the toxic concentration.…”

Section: Discussionmentioning

confidence: 99%

“…(Please see "Prophylactic functions of tea polyphenols" published by Mitsui Norin Co., Ltd. in 1995.) Such studies have experienced dramatic growth in recent years [1,17,18].…”

Section: Introductionmentioning

confidence: 99%

Role of antimutagens/anticarcinogens in cancer prevention

et al. 2000

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Recently it has become increasingly clear that chemicals found in our foods and beverages can prevent the genetic damage that leads to cancer initiation. Such substances may also affect subsequent events in the pathways that lead to cancer, and may have the potential to inhibit the mutations that allow tumor cells to become resistant to antitumor agents. We describe here the antimutagenic potential of Glabrene analogs against EMS-induced mutations utilizing modified Ames tests in S. typhimurium TA 100 and E. coli JC 5088. Results of studies of the ability of well-known antioxidants such as EGCG and related compounds to prevent drug resistance mutations in microorganisms are described, and their possible significance in the prevention of chemotherapeutic drug-resistance in tumor cells is discussed.

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“…Liquori et al [1967] suggested that SPE binds to DNA in the minor groove of the double helix, while Feurstein et al [ 19861 proposed an interaction of the compound in the major groove. SPE was one of the first antimutagens detected, reducing the spontaneous and induced mutability of several prokaryotic test systems [Johnson and Bach, 1966;Clarke, 1972; Clarke and Shankel, 1977; Gridley and McDougall, 19791. It prevents the N-methylnitrosourea-induced methylation of DNA at the N7 or O6 positions of guanine and the N3 position of adenine [Rajalakshmi et al, 19781. SPE did not have a clear antimutagenic effect on induced forward mutation in Schizosaccharomyces pombe, and indeed, in some cases, it increased the mutation frequency [McDougall and Lemontt, 19791. It failed to decrease the mutation induced by UV in Schizosaccharomyces pombe [Prendergast et al, 19841, but it reduced the micronuclei formation in bone marrow cells and the incidence of abnormal sperm head morphologies in mice treated with gamma radiation [Nandan, 19901. Moreover, SPE drastically reduced SCE formation induced by psoralen in Chinese hamster ovary cells (CHO) [Cozzi et al, 19911. 0 1994 Wiley-Liss, Inc.…”

Section: Introductionmentioning

confidence: 99%

Effects of spermine on formation of HGPRT⁻ mutants induced by ethylmethanesulfonate, methylmethanesulfonate, and mitomycin C in V79 chinese hamster cells

Fiorio¹,

Vellosi²,

Bronzetti³

1994

Environ and Mol Mutagen

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Spermine is a polyamine found in bacteria, animal, and plant tissues. It is involved in a variety of biological processes, and its interaction with DNA stabilizes the secondary structure of the double helix. Spermine is one of the first reported antimutagens, reducing the mutation rate in several prokaryotic test systems, while in eukaryotic organisms conflicting results have been obtained. In light of the significant antimutagenic effect of spermine, it is important to evaluate its activity in mammalian cells in culture. The present study was undertaken to evaluate the ability of spermine to suppress the level of HGPRT- mutants induced by ethylmethanesulfonate, methylmethanesulfonate, and mitomycin C. Spermine reduced the mutation frequency induced by ethylmethanesulfonate and methylmethanesulfonate but did not affect survival; with mitomycin C survival was reduced but mutation rate was not influenced.

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Antimutagenesis in microbial systems.

Cited by 74 publications

References 76 publications

Metabolically‐produced 'Uv‐like‐ Dna Damage and Its Role in Spontaneous Mutagenesis

Metabolically‐produced 'Uv‐like‐ Dna Damage and Its Role in Spontaneous Mutagenesis

Role of antimutagens/anticarcinogens in cancer prevention

Effects of spermine on formation of HGPRT⁻ mutants induced by ethylmethanesulfonate, methylmethanesulfonate, and mitomycin C in V79 chinese hamster cells

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Antimutagenesis in microbial systems.

Cited by 74 publications

References 76 publications

Metabolically‐produced 'Uv‐like‐ Dna Damage and Its Role in Spontaneous Mutagenesis

Metabolically‐produced 'Uv‐like‐ Dna Damage and Its Role in Spontaneous Mutagenesis

Role of antimutagens/anticarcinogens in cancer prevention

Effects of spermine on formation of HGPRT− mutants induced by ethylmethanesulfonate, methylmethanesulfonate, and mitomycin C in V79 chinese hamster cells

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Effects of spermine on formation of HGPRT⁻ mutants induced by ethylmethanesulfonate, methylmethanesulfonate, and mitomycin C in V79 chinese hamster cells