Antimüllerian hormone as predictor of reproductive outcome in subfertile women with elevated basal follicle-stimulating hormone levels: a follow-up study

Yarde, F.; Voorhuis, Marlies; Dólleman, Madeleine; Knauff, Erik A. H.; Eijkemans, Marinus J.C.; Broekmans, Frank J.

doi:10.1016/j.fertnstert.2013.05.009

Cited by 27 publications

(20 citation statements)

References 55 publications

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“…AMH should be considered a more reliable ovarian reserve assessment test compared to FSH because there was a strong positive correlation between the serum AMH level and AFC; further, the use of AMH combined with AFC may improve ovarian reserve evaluation [20]. The present findings suggest the applicability of AMH determination as a marker for actual fertility in subfertile women with elevated basal FSH levels, as AMH was significantly associated with the timing of reproductive stages (i.e., the occurrence of menopausal transition or menopause during follow-up) [21]. Our results showed that the cut-off value of age was 36.50 for predicting ovarian reserve decline and that the corresponding sensitivity and specificity were 88.0% and 40.8%, respectively.…”

Section: Discussionmentioning

confidence: 61%

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The evaluative effectiveness of a combined index exceeded that of a single variable for the ovarian reserve and response of infertile women

Zhou

Zhao

et al. 2019

Preprint

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Aim of the present study was to explore the evaluative effectiveness of age, ovarian volume, antral follicle count (AFC), serum follicle-stimulating hormone (FSH), anti-Müllerian hormone (AMH), FSH/LH ratio and ovarian response prediction index (ORPI) to determine which could most advantageously assess ovarian reserve and response.Methods This research enrolled 319 consecutive infertile women who had undergone IVF-ET/ICSI treatments. Abovementioned variables were measured and calculated. Receiver Operating Characteristic Curve analysis was used to analyze the predictive accuracy of variables and to calculate cut-off values and corresponding sensitivity and specificity.Results Our study revealed that the significant variables for evaluating a decline in ovarian reserve include age, total volume of bilateral ovary, FSH, and ORPI. Moreover, the area under the curve (AUC) of ORPI was higher than other three variables (AUC = 0.903), and the cut-off value of ORPI was 0.245 (sensitivity 90.1%, specificity 73.9%). The significant variables forecasting excessive ovarian response were age, AFC, AMH, ORPI, FSH and FSH/LH ratio, and the significant variables forecasting low ovarian response were AMH and FSH/LH ratio. ORPI and FSH/LH ratio presented better effectiveness in evaluating ovarian response. When they were used to predict excessive response, the cut-off values of ORPI and FSH/LH ratio was 0.886 (sensitivity 84.7%, specificity 67.3%) and 1.753 (sensitivity 56.2%, specificity 67.6%), respectively. When used to predict low response, the cut-off value of FSH/LH ratio was 2.983 (sensitivity 75.0%, specificity 83.8%).Conclusions ORPI performed better than did the other variables in evaluating ovarian reserve and predicting excessive ovarian response, and the FSH/LH ratio performed better than did the other variables in predicting low ovarian response. Consequently, we agreed that the evaluative effectiveness of a combined index exceeded that of a single variable for evaluating the ovarian reserve and response of infertile women.

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Section: Discussionmentioning

confidence: 61%

“…Many studies [17][18][19][20][21] have discussed how AFC and AMH could be used to assess ovarian reserve.…”

Section: Discussionmentioning

confidence: 99%

The evaluative effectiveness of a combined index exceeded that of a single variable for the ovarian reserve and response of infertile women

Zhou

Zhao

et al. 2019

Preprint

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“…A couple of patient related parameters were shown to be associated with basal AMH levels, amongst which female age [22], ovarian response [23], basal FSH [24] and medical indication [25] were shown to correlate with very low or high AMH values.…”

Section: Commentsmentioning

confidence: 99%

“…In particular, genes involved in processing oxidative stress [24] and oxidative phosphorylation [27] were affected, which may ultimately result in an overall decline of mitochondrial capacity in cumulus cells of older patients. Furthermore, tropomyosin-related kinase, thought to mediate survival signals in order to maintain a viable COC, is underexpressed in patients with low AMH showing diminished ovarian reserve [28], thus promoting apoptosis in these patients.…”

Section: Commentsmentioning

confidence: 99%

Viability of cumulus cells is associated with basal AMH levels in assisted reproduction

Ebner¹,

Shebl²,

Holzer³

et al. 2014

European Journal of Obstetrics & Gynecology and Reproductiv

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“…Estudos recentes sugerem que essa glicoproteína dimérica é superior e mais confiável, em comparação com o FSH, na avaliação da reserva ovariana. 9 O AMH nas mulheres é produzido pelas células da granulosa a partir dos folículos pré-antrais e antrais, na 36 a semanas de gestação. O AMH é expresso até os folículos atingirem um tamanho médio de 4-6 mm, estado de diferenciação no qual se tornam receptivos ao FSH exógeno.…”

Section: Avaliação Da Reserva Ovarianaunclassified

Tratamento com andrógenos como possibilidade de melhoria do prognóstico reprodutivo em mulheres com envelhecimento ovariano

Bartmann

Melo

Nascimento

et al. 2014

Reprodução & Climatério

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Antimüllerian hormone as predictor of reproductive outcome in subfertile women with elevated basal follicle-stimulating hormone levels: a follow-up study

Cited by 27 publications

References 55 publications

The evaluative effectiveness of a combined index exceeded that of a single variable for the ovarian reserve and response of infertile women

The evaluative effectiveness of a combined index exceeded that of a single variable for the ovarian reserve and response of infertile women

Viability of cumulus cells is associated with basal AMH levels in assisted reproduction

Tratamento com andrógenos como possibilidade de melhoria do prognóstico reprodutivo em mulheres com envelhecimento ovariano

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